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The invention provides a method and system for creating an innovative file system that separates its directory presentation from its data store. The method and system include processing, division, distribution, managing, synchronizing, and reassembling of file system objects that does not delay the presentation of the content to the user, but also uses a reduced amount of storage space. The invention includes the ability to manage and control the integrity of the files distributed across the network, and the ability to serve and reconstruct files in real time using a Virtual File Control System.

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

To prevent both slips caused by damage from projections, and slips caused by adhesive force occurring due to excessive smoothing.The heat treating apparatus includes a processing chamber for heat treating wafers and a boat for supporting the wafers in the processing chamber. The boat further includes a wafer holder in contact with the wafer and a main body for supporting the wafer holder. The wafer holder diameter is 63 to 73 percent of the wafer diameter, and the surface roughness Ra of the portion of the wafer holder in contact with the wafer is set from 1 μm to 1,000 μm. The wafer can be supported so that the amount of wafer displacement is minimal and both slips due to damage from projections on the wafer holder surface, and slips due to the adhesive force occurring because of excessive smoothing can be prevented in that state.

An improved system and approaches for exchanging secured files (e.g., documents) between internal users of an organization and external users are disclosed. A file security system of the organization operates to protect the files of the organization and thus prevents or limits external users from accessing internal documents. Although the external users are unaffiliated with the organization (i.e., not employees or contractors), the external users often have working relationships with internal users. These working relationships (also referred to herein as partner relationships) often present the need for file (document) exchange. According to one aspect, external users having working relationships with internal users are able to be given limited user privileges within the file security system, such that restricted file (document) exchange is permitted between such internal and external users.

Embodiments of the present invention provide verification and / or authentication service engines that provide a customizable solution that can be “dialed” based on the risk level assigned to individual or grouped applications. The systems can also incorporate internal and external sources of data used to verify information provided by the user. It is dynamic and can pull information from a myriad of sources during the verification process, enabling credit reporting agencies (e.g., Equifax and others), FSPs, and other service providers to facilitate real-time approval and access to products and services.

A computer-human interface manages the available space of a computer display in a manner which reduces clutter and confusion caused by multiple open windows. The interface includes a user-selectable mode of operation in which only those windows associated with the currently active task are displayed on the computer monitor. All other windows relating to non-active tasks are minimized by reducing them in size or replacing them with a representative symbol, such as an icon, so that they occupy a minimal amount of space on the monitor's screen. When a user switches from the current task to a new task, by selecting a minimized window, the windows associated with the current task are automatically minimized as the window pertaining to the new task is displayed at its normal size. As a result, the user is only presented with the window that relates to the current task of interest, and clutter provided by non-active tasks is removed.

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.

A computer-human interface manages the available space of a computer display in a manner which reduces clutter and confusion caused by multiple open windows. The interface includes a user-selectable mode of operation in which only those windows associated with the currently active task are displayed on the computer monitor. All other windows relating to non-active tasks are minimized by reducing them in size or replacing them with a representative symbol, such as an icon, so that they occupy a minimal amount of space on the monitor's screen. When a user switches from the current task to a new task, by selecting a minimized window, the windows associated with the current task are automatically minimized as the window pertaining to the new task is displayed at its normal size. As a result, the user is only presented with the window that relates to the current task of interest, and clutter provided by non-active tasks is removed.

The invention relates to a method and system that utilizes one or more cassettes or trays, which hold one or more types of medicaments, the cassettes or trays being configured for secure and intelligent dispensing of the medicaments. In one embodiment, a smart tray for dispensing medicaments includes: a housing; a chamber within the housing to store the medicament units; an outlet defined in the housing to dispense the medicament units; and a rotatable disk within the housing and defining at least one radial groove configured to hold at least one medicament unit, the rotatable disk being positioned between the storage chamber and the outlet whereby when the rotatable disk rotates, the at least one radial groove carries the at least one medicament unit from the chamber to the outlet. In a further embodiment, the smart tray includes a memory device within the housing to store information pertaining to the medicament units stored in the tray and / or information pertaining to the status or operation of the tray.

The invention features a vital sign monitor that includes: 1) a hardware control component featuring a microprocessor that operates an interactive, icon-driven GUI on an LCD; and, 2) a sensor component that connects to the control component through a shielded coaxial cable. The sensor features: 1) an optical component that generates a first signal; 2) a plurality electrical components (e.g. electrodes) that generate a second signal; and, 3) an acoustic component that generates a third signal. The microprocessor runs compiled computer code that operates: 1) the touch panel LCD; 2) a graphical user interface that includes multiple icons corresponding to different software operations; 3) a file-management system for storing and retrieving vital sign information; and 4) USB and short-range wireless systems for transferring data to and from the device to a PC.

This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human / animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device that analyzes the polynucleotides according to restriction fragment length polymorphism. In a microfabricated device according to the invention, DNA fragments or other molecules can be rapidly and accurately typed using relatively small samples, by measuring for example the signal of an optically-detectable (e.g., fluorescent) reporter associated with the polynucleotide fragments.

A system for displaying an external view of a vehicle is provided. The system may comprise a video camera for capturing images external to the vehicle and a display for displaying the images for the vehicle operator. The camera is powered by electrically connecting it to the reverse lamp power line and is operable to continuously capture images when powered. The camera may be mounted in a license plate frame to further simplify installation. The camera may communicate with the display through a wireless connection. The receiver and display may be mounted in the field of view of the vehicle operator, such as on the dashboard of the vehicle.

A cannulated offset drill guide and surgical methods for repairing Bankart lesions. The cannulated offset drill guide comprising a shaft which is offset from the guide center line by about 1 to 3 mm, more preferably of about 1.5 mm. The cannulated offset drill guide is provided at its proximal end with a concave clear tip which allows a surgeon to visualize the drill and the insertion of an anchoring device, for example a suture anchor. The concave clear tip has beveled, smooth edges to prevent damage to adjacent bone and tissue, and to avoid damage to the rubber dam of the cannula through which the offset drill guide is inserted. The configuration of the concave clear tip is designed to engage and match the generally convex-curve articulating face of the glenoid, and to precisely aligning the offset drill guide with the glenoid face. The clear tip may also be employed in a standard drill guide having a shaft which is not offset from the center line of the guide.

Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.

A public transit travel planning system and methodology that uses an extensive pre-processing approach of transit information prior to query time on order to determine optimal public transit routes for journeys. At query time, since the transit information has already been processed by the system, very little computation is needed in order to fulfill the query. The system then provides users with public transit directions in response to the queries for public transit journeys.

A compact lancing includes a housing, a moveable lancet holder disposed within the housing and configured to hold a lancet, a launching mechanism disposed within the housing, and arming and trigger mechanisms disposed at least partially within the housing. In addition, the launching mechanism includes a launch spring and a retraction spring. The lancet holder, launching mechanism, arming mechanism and trigger mechanism are operatively connected to lance a target site with a lancet held by the moveable lancet holder. In addition, the retraction spring is configured in an essentially concentric arrangement with the launch spring, thereby providing for compactness in design.

An apparatus and method for adapting web page content are described. The adaptation of web page content for display on smaller intended display devices often requires the splitting of the content over a number of smaller pages. The apparatus and method relate to a procedure which integrates the process of splitting the content with applying transformations (for example, reducing the font size, images, etc) so as to optimise this process. The procedure is carried out systematically over the entire web page content, recursively splitting the content into smaller and smaller portions whilst simultaneously alternating this with various transformations so as to minimise the amount of white space visible on the smaller pages. Additionally, the preferred embodiment also tracks the transformations which have been applied to the objects and ensures consistency by applying them later to any similar objects.

State of security in a mobile communications network is communicated. Data regarding nature and severity of security events onboard at least one mobile platform is generated and processed. A message that includes the processed data is generated and transmitted periodically. The processed data makes up a security state vector that includes the number of security events detected since power-up of the mobile platform node, sum of highest severity security events since power-up or counter rollover, sum of the second highest severity security events detected since power-up or counter rollover, sum of the third highest severity security events detected since power-up or counter rollover, highest security event classification, second-highest security event classification, and third-highest security event classification. The processed data may be used in a network operations center to prioritize mobile platforms from which logged data should be retrieved for further investigation and monitoring.

The invention relates to a method and system that utilizes one or more cassettes or trays, which hold one or more types of medicaments, the cassettes or trays being configured for secure and intelligent dispensing of the medicaments. In one embodiment, a smart tray for dispensing medicaments includes: a housing; a chamber within the housing to store the medicament units; an outlet defined in the housing to dispense the medicament units; and a rotatable disk within the housing and defining at least one radial groove configured to hold at least one medicament unit, the rotatable disk being positioned between the storage chamber and the outlet whereby when the rotatable disk rotates, the at least one radial groove carries the at least one medicament unit from the chamber to the outlet. In a further embodiment, the smart tray includes a memory device within the housing to store information pertaining to the medicament units stored in the tray and / or information pertaining to the status or operation of the tray.

Described and illustrated herein is an exemplary lancing device. The exemplary lancing device comprises: a first housing having spaced apart proximal and distal ends disposed along a longitudinal axis; a chassis disposed in the first housing in a fixed relationship with the first housing; a movable member disposed in the chassis and configured for movement along the longitudinal axis and in the first housing; a lancet coupled to the movable member; and a lancet depth adjustment member retained by both the first and chassis so that the lancet depth adjustment member is rotatable relative to both housings to provide for a plurality of stop surfaces to the movable member. Other embodiments and methods are also described.

Embodiments of the present invention provide verification and / or authentication service engines that provide a customizable solution that can be “dialed” based on the risk level assigned to individual or grouped applications. The systems can also incorporate internal and external sources of data used to verify information provided by the user. It is dynamic and can pull information from a myriad of sources during the verification process, enabling credit reporting agencies (e.g., Equifax and others), FSPs, and other service providers to facilitate real-time approval and access to products and services.

A solid-state relay / breaker that can replace mechanical units to control any type of AC or DC load. Power MOSFETs or other transistors control a load current. A bypass current sensing path monitors MOSFET current and causes a shutdown through signal processing in the event of an over-current condition. This shutdown resembles that of a slow-blow fuse where the rate of shutdown is proportional to the value of the current. This prevents shutdown on momentary spikes or in-rush. In addition, temperature and internal power supply voltages are monitored to determine additional operational conditions where over-temperature or voltages out of range can also cause shutdown. The MOSFET and current sensing path are turned on and off in staggered timing with different slew rates to provide built-in hysteresis. The device can be manufactured in any type of package to match any type of environment or existing replacement requirement.

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.