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165results about How to "Prevent bulk material" patented technology

Integrated active flux microfluidic devices and methods

InactiveUS6767706B2Rapid and complete exposureQuick and accurate and inexpensive analysisBioreactor/fermenter combinationsFlow mixersAntigenHybridization probe
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.
Owner:CALIFORNIA INST OF TECH

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.
Owner:CALIFORNIA INST OF TECH

Device for manipulating a tarpaulin

A device for manipulating a tarpaulin so as to selectively cover and uncover a top aperture of a container. The top aperture defines an aperture peripheral edge, the aperture peripheral edge including two substantially opposed substantially longitudinal segments. The tarpaulin is configurable between an extended configuration and a retracted configuration. In the extended configuration, the tarpaulin substantially covers the top aperture. In the retracted configuration, the tarpaulin is substantially retracted from the top aperture. The device includes an elongated guiding component defining a guiding component longitudinal axis. The guiding component is securable to the container so as to extend at least partially along at least one of the longitudinal segments. A tarpaulin mounting component is usable for attaching the tarpaulin thereto. A link, mechanically coupled to the guiding component, is longitudinally movable therealong between a link proximal position and a link distal position. The tarpaulin mounting component is operatively coupled to the link in a manner such that when the link is in the link proximal position, and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the retracted configuration. When the link is in the link distal position and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the extended configuration.
Owner:ROYER REAL

Device for manipulating a tarpaulin

A device for manipulating a tarpaulin so as to selectively cover and uncover a top aperture of a container. The top aperture defines an aperture peripheral edge, the aperture peripheral edge including two substantially opposed substantially longitudinal segments. The tarpaulin is configurable between an extended configuration and a retracted configuration. In the extended configuration, the tarpaulin substantially covers the top aperture. In the retracted configuration, the tarpaulin is substantially retracted from the top aperture. The device includes an elongated guiding component defining a guiding component longitudinal axis. The guiding component is securable to the container so as to extend at least partially along at least one of the longitudinal segments. A tarpaulin mounting component is usable for attaching the tarpaulin thereto. A link, mechanically coupled to the guiding component, is longitudinally movable therealong between a link proximal position and a link distal position. The tarpaulin mounting component is operatively coupled to the link in a manner such that when the link is in the link proximal position, and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the retracted configuration. When the link is in the link distal position and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the extended configuration.
Owner:ROYER REAL
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