The invention relates to a flexographic printing water-based ink for food packaging, which comprises an acrylic resin binder, an addition agent, a colorant and deionized water. The flexographic printing water-based ink is good in moving resistance after solidified crosslinking is adopted and is prepared by premixing, sanding and dispersing water-based polyacrylic acid resin having no toxic effect on the human body, food-grade colorants, addition agents and the like according to a fixed proportion. The obtained ink utilizes flexographic printing to form pictures, and after high-temperature drying treatment is performed to a sample, the ink is high in adhesion, resists hot water of 80 DEG C and has a certain acidproof and alkaliproof performance. The water-based ink can replace traditional solvent ink, is applied to various plastics and paper printing, and is particularly used for the printing surface (such as the surface of a paper plate) directly contacted with food or the printing surface of a toy possibly closely contacted with sense organs of infants, thereby greatly improving safety performance.