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77results about How to "High imaging sensitivity" patented technology

Sound field measuring apparatus and measuring method

The invention discloses a sound field measuring apparatus. Light emitted by a laser is successively reflected by a sound field generated by a transmitting lens, a collimator lens, a half mirror and anacoustic transducer as well as a reflection mirror and is then returned by virtue of the original sound field, after the light beam is deflected for 90 degrees by virtue of a light splitter, the light passes through a Fourier transform lens to perform the space filter treatment on a rear focal plane of the Fourier transform lens, so that the sound-field imaging can be realized; an image sensor ismoved to the rear focal plane of a variable lens to receive a diffraction spot, a sound speed can be calculated according to the distance of the diffraction spot, and the sound pressure is calculatedaccording to the distribution of the spot intensity; and a diaphragm is arranged between the sound field and the light splitter and can be used for measuring the sound pressure of a local sound fieldarea. By adopting the sound field measuring apparatus, the imaging of the sound fields in various forms in transparent fluid can be realized, and the plane sound field, the approximate plane sound field and the intensity of the approximate plane sound field area in the sound field can be quantitatively measured; by virtue of the calibration of the transducer, the measurement of a pulse wave and continuous traveling wave plane sound field or approximate plane sound field can be realized; and by adopting the reflection mirror, the light passes through the sound field twice, so that the imagingand measuring sensitivity can be improved.
Owner:HOHAI UNIV CHANGZHOU

Electrical impedance imaging method

The invention discloses an electrical impedance imaging method, and belongs to the technical field of electrical impedance scanning and imaging. The method disclosed by the invention comprises: step 1, respectively arranging a first electrode device and a second electrode device contacting with the surface of an object to be imaged at the two opposite sides of the object to be imaged, and enabling the first electrode device and the second electrode device to apply a constant clamp force onto the object to be imaged; step 2, applying an input electric signal via the first electrode device, acquiring the output electric signal of the second electrode device, and obtaining the current distribution of the object to be imaged under the clamp force; step 3, changing the clamping forced applied on the object to be imaged by the first electrode device and the second electrode device, and repeating the step 2; and step 4, constructing the impedance image of the object to be imaged according to the current distribution difference value of the object to be imaged between two different clamp forces. Compared with the prior art, the method disclosed by the invention has the advantages of higher sensitivity, good electrode contact antifact inhibition effect, and low implementation cost.
Owner:SOUTHEAST UNIV

Photo-acoustic microscopic imaging system and method based on surface plasmon resonance

The invention discloses a photo-acoustic microscopic imaging system and method based on surface plasmon resonance. The system generates exciting light, the exciting light acts on photo-acoustic wavesacting on a liquid interface and generated and returned by a measured object, a refraction index of the liquid interface is changed along with variation of the pressure of the photo-acoustic waves, the system further generates probe light, a probe light path acts on a metal film, so that the metal film generates surface plasmon resonance, the probe light path senses variation of the refraction index of the liquid interface at a surface plasmon resonance position, a phase position of the probe light is changed, the system further generates Michelson interference, light intensity interference value is acquired, and a contrast image is generated according to the light intensity interference value. According to the photo-acoustic microscopic imaging system and method, a system detection bandwidth is improved by the aid of a strong local effect of tight focusing vector light, and a sensor can improve imaging sensitivity by a phase-type analysis mode, so that the photo-acoustic microscopic imaging system with high signal-to-noise ratio and broad-spectrum detection capability is achieved.
Owner:SHEN ZHEN SHEN GUANG SU TECH CO LTD

Preparation method of sericin-gadolinium pH responsive targeting tumor nuclear magnetic resonance contrast agent

The invention belongs to the technical field of magnetic resonance imaging (MRI) contrast agents, and discloses a preparation method of a sericin-gadolinium pH responsive targeting tumor nuclear magnetic resonance contrast agent. The contrast agent is used for enhancing MRI research of tumor tissues, sericin, gadolinium acetate hexahydrate and gadolinium chloride hexahydrate are adopted as raw materials, and the nano contrast agent SS@GAH-GdCl3 is synthesized through a Schiff base reaction. Amino groups of the sericin and aldehyde groups of the gadolinium acetate hexahydrate are subjected to aone-step reaction by a two-step method to form Schiff base, and gadolinium ions are supplemented through electrostatic adsorption of the gadolinium chloride hexahydrate. The contrast agent prepared by the method can smoothly pass through normal tissues and blood vessels, and the surface potential of the contrast agent can be automatically reversed at a tumor part to enter tumor tissues, so that the uptake of tumor cells is increased, and the precise MRI contrast of solid tumors is realized; and the metabolism time of the nano contrast agent is remarkably prolonged by 30-60 min, and is far longer than the pharmacokinetic time of a commercial gadodiamide injection.
Owner:SOUTHWEST UNIV
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