6results about How to "High imaging sensitivity" patented technology

The invention discloses a material mechanical behavior in-situ testing device under neutron and X-ray fusion imaging, which belongs to the technical field of material mechanical behavior testing and comprises a mechanical loading testing module, a positioning supporting module, a variable-temperature loading module, an X-ray phase contrast imaging module and a neutron imaging module. X-ray phase contrast imaging is adopted, and the imaging sensitivity is high; the movable base can drive the space positions of the modules such as the test cassette and the neutron imaging module, and can match the neutron receiver to the same axis with the neutron traceability emitter, so that the problem that the neutron imaging module and the X-ray imaging module are difficult to integrate into one system is solved; in the mechanical loading process, the loading arm can drive the sample to rotate by 360 degrees, so that the X-ray phase contrast imaging module and the neutron imaging module can complete comprehensive scanning of the sample in the mechanical loading and heat loading processes of the sample; the problem that neutron and X-ray imaging and the loading process cannot be synchronously carried out due to space conflicts is solved.

The invention relates to the technical field of biomedical ultrasonic imaging, and discloses a Doppler imaging method and system based on multi-angle plane wave Hadamard coding, and the method comprises the steps: transmitting N groups of ultrasonic waves which are subjected to phase coding through Hadamard coding into a blood flow imaging region, each group of ultrasonic waves comprises N continuous plane waves which are different in angle and are separated by a preset time delay, N groups of ultrasonic echo signals are collected and decoded to obtain ultrasonic echo signals, and the step is repeatedly executed to obtain continuous multi-angle ultrasonic echo signals; moreover, according to the continuous multi-angle ultrasonic echo signals, an instantaneous blood flow image signal corresponding to the time window is obtained; a matrix equation set is constructed and solved to obtain the blood flow vectorization speed, a blood flow vector speed field transient image is generated, and / or a blood flow vector speed field dynamic change image is displayed. According to the method, the signal-to-noise ratio of plane wave imaging and the imaging sensitivity to weak blood flow signals can be remarkably improved.

The application relates to the technical field of magnetic particle imaging, and more particularly to an iron oxide nanoparticle and application of the iron oxide nanoparticle in magnetic particle imaging. The nanoparticle is an octahedral superparamagnetic ferroferric oxide nanoparticle, the nanoparticle is synthesized by adding a surfactant and controlling a reaction rate through a high-temperature thermal decomposition method, the surfactant includes oleic acid and oleylamine, the octahedral superparamagnetic ferroferric oxide nanoparticle is coated with an amphiphilic polymer, the amphiphilic polymer includes polymaleic anhydride-1-octadecenoic acid and polystyrene maleic anhydride copolymer, and the outer layer of the amphiphilic polymer includes biological membranes such as macrophage membranes, red blood cell membranes, neutrophil membranes and tumor cell membranes according to biological application requirements. The surface of the octahedral magnetic particle is a crystal face, the crystal face has low spin disorder and low anisotropy, so that the octahedral magnetic particle has the advantages of low coercivity and high initial magnetic susceptibility, and thus becomes a high-sensitivity magnetic particle imaging tracer.

The invention discloses a water-soluble near-infrared aggregation-induced emission coumarin-quinolyl viscosity fluorescent probe and application thereof, and the water-soluble near-infrared aggregation-induced emission coumarin-quinolyl viscosity fluorescent probe is realized by the following method: carrying out Knoevenagel condensation reaction on a 7-(N, N '-diphenylamino)-coumarin-3-formaldehyde compound and 1, 2-dimethyl quinoline iodized salt as raw materials under the catalytic action of p-toluenesulfonic acid and piperidine to synthesize the water-soluble near-infrared aggregation-induced emission coumarin-quinolyl viscosity fluorescent probe. The chemical structural formula is shown as a formula (III). The preparation method has the advantages of simple reaction steps, mild reaction conditions and high yield. The fluorescent probe emits fluorescence in a near-infrared region, has the advantages of large Stokes shift, low background interference, small light damage to biological samples and the like, has aggregation / viscosity-induced fluorescence enhancement capability, and can be used for detecting viscosity changes in solutions and cells. And an effective research tool is provided for researching physiological activities under different viscosities in cells.

This invention discloses a multicolor fluorine magnetic resonance imaging probe based on a metal-organic cage. First, a rhodium-based metal-organic cage is formed by the self-assembly of a fluorinated isophthalic acid ligand and a rhodium salt, covalently introducing the first characteristic fluorine signal. Then, leveraging the coordination ability of the rhodium nodes in the rhodium-based metal-organic cage, it coordinates with a fluorinated pyridine derivative, introducing a second characteristic fluorine signal. This results in a multicolor probe containing both fluorine signals within the metal-organic cage, ensuring that all signals exhibit completely consistent pharmacokinetic behavior in vivo. This achieves true multi-channel synchronous imaging, solving the fundamental problem of spatiotemporal asynchrony of mixed probe signals. The probe system of this invention features precise structure, strong design flexibility, high imaging sensitivity, and multicolor imaging capabilities, providing a new solution for existing fluorine probes with single-channel imaging or complex structures. It also provides a new tool for in vivo multi-target biological imaging and dynamic monitoring.

The invention relates to the technical field of neonatal MRI imaging devices, and provides a neonatal MRI imaging device which comprises an imaging unit, a head fixing device and a matched bed body facilitating testing, the head fixing device is of a helmet type structure and comprises an upper cover body and a base, and a flexible coil module used for imaging is arranged in the imaging unit.