Blood plasma separation adsorber capable of blood purification

A plasma separation and blood purification technology, applied in suction devices and other directions, can solve the problems of high cost of a full set of plasma adsorption devices, inability of rapid diffusion of macromolecular substances, and difficult plasma adsorption treatment modes, so as to reduce the risk of blood incompatibility, Simple structure and low cost

Active Publication Date: 2014-12-03
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this process, there are many devices connected in series, the operation of medical staff is difficult, and the amount of blood in extracorporeal circulation is large, and there are many medical devices in contact, which not only increases the physical burden of patients, but also causes problems such as hemolysis and coagulation. The probability of occurrence increases, which increases the safety risk during treatment
In addition, the cost of a complete set of plasma adsorption equipment is relatively high
The above-mentioned problems make it difficult for the plasma adsorption therapy mode to be widely promoted in China
[0004] In addition, spherical macroporous resins are generally used as the adsorbent carrier of plasma adsorption columns in the market at present, and macromolecular adsorbents are obtained by grafting functional ligands in the resin micropores. It cannot be too large, and the number of macropores cannot be too large, which increases the difficulty of grafting functional groups on spherical resins, and also prevents macromolecular substances from quickly diffusing into micropores, which leads to spherical resin adsorbents. The effective adsorption area of ​​macromolecular substances is much smaller than the measured actual surface area

Method used

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  • Blood plasma separation adsorber capable of blood purification
  • Blood plasma separation adsorber capable of blood purification
  • Blood plasma separation adsorber capable of blood purification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] combined reference figure 2 and image 3 The plasma separation adsorber A includes: a shell 1, a hollow fiber membrane 21, a fibrous adsorbent 31 with island-in-the-sea fibers as a carrier, a sealant layer 14, and a sealant layer 2 15.

[0025] The plasma separation adsorber A in this embodiment is vertical, and the housing 1 includes a top cover 11 , a bottom cover 12 and a cylinder 13 . The inner space of the housing surrounded by the top cover 11 , the bottom cover 12 and the cylinder 13 is divided into three chambers by the first sealant layer 14 and the second sealant layer 15 . This part is structured with figure 1 The structure of the plasma separator is basically the same, for the sake of saving, it will not be repeated here.

[0026] In this embodiment, the three chambers inside the housing 1 are an inlet buffer chamber 16 , a blood purification chamber 17 and an outlet buffer chamber 18 from top to bottom. The wall of the inlet buffer chamber 16 is provid...

Embodiment 2

[0032] The structure of this example is basically the same as that of Example 1, except that the fibrous adsorbent is different. In this example, the fibrous immunosorbent is obtained after immobilizing tryptophan on the fibrous carrier.

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PUM

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Abstract

The invention discloses a blood plasma separation adsorber, comprising a shell. An inlet cushion chamber, an outlet cushion chamber and a blood purifying chamber are arranged in the shell. A blood inlet is arranged on the wall of the inlet cushion chamber; a blood outlet is arranged on the wall of the outlet cushion chamber; a blood plasma outlet is arranged on the wall of the blood purifying chamber; at least a hollow fibrous membrane is arranged in the blood purifying chamber and two ends of each hollow fibrous membrane are communicated with the inlet cushion chamber and the outlet cushion chamber respectively; and at least a fiber-shaped adsorbent is arranged in the blood purifying chamber. The adsorber has the advantages of simultaneous blood plasma separation and adsorption, shortened process of blood plasma adsorption and reduced blood amount of extracorporeal circulation, thereby reducing burden of patients and risks of incompatibility of blood.

Description

technical field [0001] The invention relates to a blood purification device, in particular to a plasma separation adsorber capable of simultaneously performing plasma separation and plasma adsorption. Background technique [0002] Plasma adsorption therapy has little damage to blood cells and has little impact on the internal environment of the human body, and has been widely used in the field of blood purification. The basic principle of plasma adsorption therapy is to introduce blood from the patient's body to the outside of the body, firstly separate the plasma from blood cells, and then specifically adsorb and remove the pathogenic substances in the plasma to achieve the purpose of treating diseases. Depending on the selected adsorbent, this treatment method can be used to treat human autoimmune diseases, metabolic diseases, and endogenous poisoning. [0003] figure 1 It is a flow chart of the current common plasma adsorption therapy. As shown in Figure 1, the blood f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/18
Inventor 董凡
Owner JAFRON BIOMEDICAL
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