Levofloxacin hydrochloride tablet and preparation method thereof

A levofloxacin hydrochloride tablet and a technology of levofloxacin hydrochloride are applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., which can solve problems such as being unable to be absorbed by the human body, affecting drug efficacy, etc., to improve bioavailability, reduce The effect of intestinal fluid alkalinity

Active Publication Date: 2014-01-22
NANJING REDWOOD FINE CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the alkaline environment of the small intestine, part of levofloxacin precipitates and crystallizes, which cannot be absorbed by the human body and affects the efficacy of the drug

Method used

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  • Levofloxacin hydrochloride tablet and preparation method thereof
  • Levofloxacin hydrochloride tablet and preparation method thereof
  • Levofloxacin hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 levofloxacin hydrochloride tablet and preparation method thereof

[0024]

[0025] Preparation Process:

[0026] Pass levofloxacin hydrochloride, microcrystalline cellulose, and crospovidone through a 100-mesh sieve, weigh the prescription amount, mix evenly, add an appropriate amount of pure water to granulate, dry at 60°C, and sieve through a 18-mesh sieve to obtain levofloxacin hydrochloride granules; Weigh citric acid and polyvinyl acetate phthalate prescription amount, dissolve in ethanol, dry at 50°C to remove ethanol, and pass through a 60-mesh sieve to obtain citric acid enteric-coated granules; mix the two granules, add hard Magnesium fatty acid is mixed, and compressed into tablets to obtain levofloxacin hydrochloride tablets.

Embodiment 2

[0027] Embodiment 2 levofloxacin hydrochloride tablet and preparation method thereof

[0028]

[0029] Preparation Process:

[0030] Pass levofloxacin hydrochloride, lactose, and crospovidone through a 100-mesh sieve, weigh the prescription amount, mix evenly, add an appropriate amount of pure water to granulate, dry at 60°C, and sieve through a 20-mesh sieve to obtain levofloxacin hydrochloride granules; Acid and polyvinyl acetate phthalate were weighed, dissolved in ethanol, dried at 55°C to remove ethanol, and passed through 80 sieves to obtain citric acid enteric-coated granules; mix the two granules, add magnesium stearate and mix , tableted to obtain levofloxacin hydrochloride tablets.

Embodiment 3

[0031] Embodiment 3 levofloxacin hydrochloride tablet and preparation method thereof

[0032]

[0033] Preparation Process:

[0034] Pass levofloxacin hydrochloride, microcrystalline cellulose, and croscarmellose sodium through a 100-mesh sieve, weigh the prescription amount, mix well, add an appropriate amount of pure water to granulate, dry at 60°C, and sieve through a 20-mesh sieve to obtain hydrochloric acid Levofloxacin granules; weigh the prescription amount of citric acid and polyvinyl acetate phthalate, dissolve them in ethanol, dry at 55°C to remove ethanol, and pass through 80 sieves to obtain citric acid enteric-coated granules; mix the two granules, Magnesium stearate is added for mixing, and tabletted to obtain levofloxacin hydrochloride tablets.

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PUM

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Abstract

The invention discloses a levofloxacin hydrochloride tablet and a preparation method of the levofloxacin hydrochloride tablet. The preparation is prepared by blending and tabletting medicine-containing particles, citric acidenteric particles and a lubricant, wherein the citric acidenteric particles is prepared by dissolving the citric acid and the polyvinyl acetatephthalic acid ester in ethyl alcohol. According to the invention, the citric acid is wrapped in an enteric material and is not dissolved in the stomach, the citric acid is dissolved and released in the intestines, so that the alkalinity of the intestinal juice is reduced, the levofloxacin hydrochloride is enabled not to be separated out, and therefore, the bioavailability of the medicine is improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a solid oral preparation of levofloxacin hydrochloride, in particular to a levofloxacin hydrochloride tablet and a preparation method thereof. Background technique [0002] Levofloxacin is the active ingredient L-isomer in ofloxacin (racemic). Its mechanism of action and antibacterial characteristics are the same as those of ofloxacin, but its antibacterial effect is slightly stronger than that of ofloxacin. Levofloxacin can inhibit DNA gyrase, block DNA replication, and lyse bacteria in an environment several times higher than the minimum inhibitory concentration. Levofloxacin has definite in vitro antibacterial effect on Gram-positive and Gram-negative bacteria, and its antibacterial effect on Gram-negative bacteria is far greater than that of Gram-positive bacteria. Its in vitro antibacterial effect is slightly stronger or similar to that of no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5383A61K47/34A61P31/04A61K31/194
Inventor 不公告发明人
Owner NANJING REDWOOD FINE CHEM CO LTD
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