178 results about "Aryl ketone" patented technology

The invention discloses an alcohol dehydrogenase, a gene thereof, a recombinant expression vector and a recombinant expression transformant respectively containing the gene, a recombinase of the alcohol dehydrogenase, and an application of the alcohol dehydrogenase in asymmetric reduction synthesis of chiral diaryl secondary alcohol as a catalyst, and belongs to the technical field of bioengineering. The alcohol dehydrogenase is from Kluyveromyces sp. CCTCCM2011385, has a carbonyl group reduction function, and also has a hydroxy group oxidation function. Extra addition of glucose dehydrogenase and other enzymes used for cofactor circulation is not needed when the alcohol dehydrogenase is used in the reduction of diaryl ketone into the chiral diaryl secondary alcohol as a biocatalyst, and the alcohol dehydrogenase has the advantages of high catalysis efficiency, mild reaction conditions, easy product recovery and low cost, so the alcohol dehydrogenase has very good application and exploitation prospect in the production of antihistamine medicines.

An ink composition comprised of (1) an ink vehicle of (a) alkyl alkyl ketones of the formula CH3(CH2)m CO (CH2)n CH3 where m and n represent the number of segments and wherein alkyl contains from about 1 to about 25 carbons, (b) alkyl aryl ketones where each alkyl contains from about 1 to about 20 carbons, and the aryl is anthracene, naphthalene or phenyl, (c) arylaryl ketones where each aryl is benzyl, phenyl or naphthyl, (2) an ink viscosity component, (3) a conductive compound, (4) an antioxidant compound, (5) a lightfastness component, and (6) a colorant.

The invention relates to chiral beta-arylamine compounds prepared by asymmetric reductive amination reaction and a preparation method of the chiral beta-arylamine compounds. The chiral beta-arylamine compounds are prepared by hydrogenised asymmetric reductive amination reaction under the action of chiral catalysts on the basis of alpha-aryl ketone and aminodiphenylmethane. By the synthesis method, catalyst consumption can be reduced to 5*10<-5>, enantioselectivity of products is up to 98%, and a diaryl methyl group can be removed from N-diaryl methyl-beta-arylamine obtained from the reaction under mild conditions to finally obtain first-grade beta-arylamine, so that the problem of synthesis of the chiral beta-arylamine compounds is solved. In addition, since relevant raw materials are very cheap, the chiral beta-arylamine compounds and the preparation method have extremely high industrial application potential.

The invention relates to the field of catalysis, in particular to a method for preparing aryl ketone through reacting aldehyde with aryl boric acid under the catalysis of a ruthenium catalyst. In the method, an organic phosphide is used as a ligand, potassium phosphate is used as alkali, pinacolone or acetone is used as an additive, toluene or/and water is (are) used as a solvent(s), aldehyde and aryl boric acid which are used as reaction substrates react at 95-100 DEG C for 10-24h in the presence of a ruthenium compound used as a catalyst to prepare aryl ketone, wherein the catalyst is one of [Ru(cymene)Cl2]2, [Ru(CO)3Cl2]2, RuH2(CO)PPh3, Ru2(OAc)4, [Ru(benzene)Cl2]2, Ru(S-BINAP)Cl2 or Ru3(CO)12. In the invention, the used catalyst has relatively low price and low toxicity, thereby reducing the preparation cost and being more environmentally friendly.

Compounds useful as surface coating agents, including compounds of the formula:

wherein X₁ comprises a first photoreactive species; X₂ comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X₁ and X₂ can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives. Examples of such coating agents include 4,5-bis(4-benzoylphenylmethyleneoxy)benzene-1,3-disulfonic acid di(potassium and/or sodium) salt, 2,5-bis(4-benzoylphenylmethyleneoxy)benzene-1,4-disulfonic acid di(potassium and/or sodium) salt (Compound II), and 2,5-bis(4-benzoylphenylmethyleneoxy)benzene-1-sulfonic acid monopotassium and/or monosodium salt.

The invention relates to an alkyl and aryl ketone compound synthetic method. The method comprises a step of enabling an aliphatic nitrile compound to react with aryl sodium trifluoroborate in an organic solvent in the presence of a palladium catalyst, dipyridyl and trifluoroacetic acid so as to prepare the target product through one step. The method has the advantages of high product yield, convenience in operation, simple method and the like; and the method has a good scientific research value and an industrial application prospect.

The invention relates to optical activity di(heteto)aryl methanol and an asymmetric synthesis method thereof. The method comprises the following steps: taking mono-sulfonyl chiral diamine and a complex of metals ruthenium, rhodium and iridium as catalysts, taking sodium formate or formic acid/triethylamine or isopropanol as a hydrogen source, carrying out an asymmetric transfer hydrogenation reaction of di(heteto)aryl ketone first, thereby obtaining the optical activity di(heteto)aryl methanol. The method is mild in reaction conditions, easy and convenient to operate, readily available in raw materials, wide in substrate application range and high in enantioselectivity and has important application prospects in the aspects of synthesis of antihistamine chiral drugs such as diphenhydramine, methyldiphenhydramine, carbinoxamine and bepotastine.

The invention relates to a preparation method of an optically active aryl vicinal diol by reducing an alpha-hydroxy aromatic ketone under catalysis of whole yeast cells, belonging to the technical field of optically active alcohol preparation utilizing a biological catalysis method. According to the invention, the whole yeast cells are used as a biocatalyst to catalyze the asymmetric reduction of the alpha-hydroxy aromatic ketone, so as to obtain high substrate conversion rate and high enantiomeric excess value of a product. Based on the invention, when the substrate concentration is 5.0-15 g/L, different conditions of whole yeast cell catalyst systems are selected according to the different substrates, thus the conversion rate of the substrate (alpha-hydroxy aryl ketone) reaches 72.4-98.4% and the enantiomeric excess value of the product (optically active aryl vicinal diol) reaches 92.2-99.7%, and the preparation has high application value.

Cell attachment coatings for articles such as implantable medical devices and cell culture vessels are disclosed. The coatings include an intermediate coater layer which includes a sulfonated component that is bonded in the coating by reacted aryl ketone functional groups. The coating also include a second coated layer including an immobilized ECM protein or peptide that includes an active portion of an ECM protein that is able to serve as an outer layer to contact cells during use. The coatings promoted enhanced cell binding and growth.

The invention discloses a method for preparing diaryl ketone from aryl sulfonate. The method includes following steps: in the presence of a catalyst and carbon monoxide, allowing aryl sulfonate and aryl boronic acid to react in an organic solvent; after reaction is finished, performing aftertreatment to obtain diaryl ketone. Aryl sufonate is adopted as an electrophilic reagent for Suzuki cross carbonylation coupling reaction, diaryl ketone is directly synthesized through carbon monoxide, aryl sulfonate and aryl boronic acid, reaction conditions are milk, functional groups are high in tolerance, a substrate is cheap and easy to get, and diaryl ketone can be prepared with high yield.

A resin composition comprises a resin component containing 40 to 99% by mass of a poly(aryl ketone) and 1 to 60% by mass of a poly(arylene sulfide), and 0.1 to 5 parts by mass, per 100 parts by mass of the resin component, of at least one thermosetting imide resin selected from the group consisting of a polyfunctional unsaturated imide compound and its thermoset product. The resin composition is improved in terms of compatibility, moldability or formability, melt flowability, mechanical properties, etc. while maintaining high levels of various properties such as heat resistance, flame retardancy, chemical resistance and dimensional stability.

The invention discloses a method for synthesizing an alpha,beta-unsaturated aryl ketone compound from dimethyl sulfoxide and arylethanone. According to the method, dimethyl sulfoxide and arylethanoneare subjected to a one-pot reaction in the presence of carboxylate and persulfate so as to produce the alpha,beta-unsaturated aryl ketone compound. The method uses dimethyl sulfoxide as a methylenation reagent and employs a one-pot process for high-selectivity high-yield synthesis of the alpha,beta-unsaturated aryl ketone compound from arylethanone; and the method is simple to operate, low in cost, friendly to environment and beneficial for industrial production.