24 results about "Aryl ketone" patented technology

The invention discloses a phosphorus-containing oxynitride compound based on a cycloarane skeleton and a ferrocene skeleton and a preparation method and application thereof, the phosphorus-containing oxynitride compound based on the cycloarane skeleton and the ferrocene skeleton is selected from at least one of compounds with structural formulas as shown in a formula I and a formula II, wherein Ar is independently selected from phenyl and C7-C15 substituted aryl; the substituent group of the substituted aryl group is selected from one of C1-C4 alkyl groups and methoxyl groups. According to the invention, a class of novel phosphorus-nitrogen-oxygen-containing compounds which have two planar chirality and are based on the cycloarane skeleton and the ferrocene skeleton can be effectively synthesized; as a ligand, the compound shows excellent catalytic activity and enantioselective control ability in asymmetric hydrogenation of an iridium-catalyzed N-aryl indolone compound or a heterobiaryl ketone compound.

The invention relates to the technical field of catalysts, in particular to a neutral nickel catalyst as well as a ligand, a preparation method and application thereof, and the ligand has a structure as shown in a formula I. According to the invention, a series of novel neutral nickel complexes with sandwich-like structures are developed based on an amide-aryl ketone skeleton structure for the first time; the series of catalysts are simple and efficient to synthesize, the ligand synthesis yield is greater than or equal to 80%, and the catalyst synthesis yield is greater than or equal to 80%; nuclear magnetic resonance monitoring shows that the nickel catalyst provided by the invention has high stability in air and does not deteriorate within 72 hours; during polymerization, no extra cocatalyst needs to be added, and the catalyst shows extremely excellent thermal stability and capability of inhibiting chain transfer side reaction in a solution copolymerization process and can resist poisoning of acrylate monomers at the same time.

The present application relates to the technical field of force-induced color-changing materials, in particular to an arylmethanone derivative containing a tetraphenylethylene and carbazole unit, a preparation method thereof and application thereof. The structural formula of the arylmethanone derivative containing a tetraphenylethylene and carbazole unit is shown in the following: after being subjected to an acting force, the arylmethanone derivative not only has obvious color change, but also has significantly increased fluorescence emission intensity, can realize high-contrast fluorescence recording, and can be widely applied to inkless writing.

The invention relates to a synthesis method of alpha chiral aryl ketone, and belongs to the technical field of chemical synthesis. The method comprises the following step: reacting a compound a, a compound b and a compound c in the presence of a catalyst, a ligand, alkali, silane and a solvent to obtain a compound d. The method has the advantages of high yield, high ee value and excellent technical effect.

The invention relates to a chiral ferrocene skeleton PNNO tetradentate ligand and application thereof in asymmetric hydrogenation reaction. The ligand has the advantages of simple synthesis, good stability, high selectivity and the like. A metal complex of the ligand shows very excellent catalytic activity and extremely high enantioselectivity in an asymmetric hydrogenation reaction of ketone, can efficiently catalyze reduction of prochiral ketones such as aryl alkyl ketone, heteroaryl alkyl ketone, aryl (hetero) aryl ketone, aliphatic ketone and the like into corresponding chiral alcohol, and has huge industrial application potential.

The invention relates to an aryl ketone-based poly (aryl-alkylene) polymer electrolyte as well as a preparation method and application thereof, and belongs to the technical field of compound synthesis. The compound is obtained by carrying out functionalization reaction on aryl ketone polymers, the functionalization reaction is selected from one or more of quaternization reaction, sulfonation reaction and phosphorylation reaction; wherein x is any integer greater than or equal to 1, and y is an integer greater than or equal to 0; a and C are aryl structural units; and B and D are alkylene structural units obtained by reaction of ketone monomers. The aryl ketone-based poly (aryl-alkylene) polymer electrolyte has the advantages of high ionic conductivity, long service life, good mechanical property and the like. The preparation is simple, the reaction condition is mild, the operation is easy, the cost is low, and large-scale industrial production can be realized.

The invention discloses a preparation method and application of a fluorine-containing aryl ketone compound, and relates to the technical field of organic synthesis.The preparation method comprises the following steps that fluorine-containing olefin, a benzoyl cyanide compound and a boric acid compound serve as raw materials and react under visible light irradiation in the presence of a photocatalyst, alkali and an organic solvent, and the fluorine-containing aryl ketone compound is prepared; the fluorine-containing olefin is used as a key fluorine-containing substrate, multi-component synergistic reaction is realized through visible light catalysis, the problems of substrate limitation, poor selectivity, low yield and the like in an existing method are solved, and the prepared fluorine-containing aryl ketone compound can be used for preparing antibacterial, anti-inflammatory and anti-cancer drugs and has high economic benefits.

The invention provides a method for preparing a polysubstituted aromatic hydrocarbon compound from an aromatic ketoxime derivative and a product. Specifically, the method comprises the following steps: (i) under the catalysis of a palladium catalyst, carrying out palladium / norbornene catalyzed Catellai reaction on a compound as shown in a formula II and compounds as shown in a formula III and a formula IV to obtain a polysubstituted aromatic hydrocarbon compound as shown in a formula I; wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. According to the method disclosed by the invention, a plurality of substituent groups can be introduced to various aromatic rings, so that the substrate range can be greatly expanded, rapid structural modification of natural products and drug molecules is realized, and the method has a wide application prospect.

A resin composition containing a polyaryl ketone, the resin composition containing a polysiloxane having a structure represented by formula (1), a peak corresponding to a cyclic siloxane being detected in pyrolysis GC / MS of the resin composition, and the content ratio of the polysiloxane in the resin composition being 0.25-1.25 mass%. (In formula (1), R1 and R2 each independently represent an alkyl group having 1-3 carbon atoms)

The present application belongs to the technical field of medicine, and relates to a use of an indole-3-aryl ketone derivative in preparation of a medicine for treating or preventing an infectious disease caused by Staphylococcus aureus, in particular, in preparation of a medicine for treating or preventing an infectious disease caused by drug-resistant Staphylococcus aureus. A chemical structural formula of the indole-3-aryl ketone derivative of the present application is shown as formula I. The results of the present application show that the compound I (i.e. the indole-3-aryl ketone derivative shown as formula I) exhibits strong inhibitory activity on methicillin-resistant Staphylococcus aureus ATCC43300, and the inhibitory effect is dependent on a concentration gradient, and the MIC 50 value is 27.45 ug / mL, while the MIC 50 value of the positive medicine, streptomycin sulfate, is greater than 200 ug / mL. Therefore, the indole-3-aryl ketone derivative can be used in treatment or prevention of an infectious disease caused by Staphylococcus aureus.

The application discloses a cytochrome P450 monooxygenase P450PL2 mutant and application thereof in the field of biotechnology. The P450PL2 enzyme derived from the doderlein bacillus DS-1 is subjected to multiple rounds of directional modification through the technical means of iterative saturation mutation, and a P450PL2 mutant with improved asymmetric hydroxylation activity is obtained, and the corresponding amino acid sequence is shown as SEQ ID No. 3. The P450PL2 mutant can be applied to catalyze the asymmetric hydroxylation of aryl ketone compounds to synthesize S configuration chiral alpha-hydroxy ketone compounds. The reaction has strict regioselectivity and stereoselectivity, and the operation process is simple and efficient.

The application discloses an asymmetric bis-aryl ketone compound and a synthesis method thereof. The method uses aryl anhydride and aryl bromide as main raw materials, N,N dimethylacetamide as a solvent, 5mol% of bis(triphenylphosphine)palladium dichloride and 5mol% of ethylene glycol dimethyl ether nickel bromide as catalysts, 10mol% of 2-(dicyclohexylphosphine) 3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl and 5mol% of alpha,alpha,alpha-tripyridine as ligands, one equivalent of sodium sulfate as an additive, two equivalents of zinc powder as a reducing agent, is placed into a reaction container under a nitrogen atmosphere, heated to 40 DEG C, and reacted for 12 hours to obtain the asymmetric bis-aryl ketone compound I with high yield. The method has the advantages of simple operation, mild reaction condition, high yield, few additives, high selectivity and the like, and has certain feasibility for realizing industrial production.

The invention relates to preparation and application of polyaryl ketone based on Claisen polycondensation and a functional derivative of the polyaryl ketone. The claisen polycondensation reaction is creatively applied to the synthesis of the polyaryl ketone material. Through precise design of reaction substrates, controllable construction of polymers with different microstructures is realized, and various polymers with clear structures such as linear polyaryl ether ketone, star-shaped polyaryl ketone and fluorescent polyaryl ketone are successfully prepared. Furthermore, through post-modification reactions such as Bayer-Villiger oxidation and ketoamine condensation, the polyaryletherketone is efficiently converted into a series of functional materials such as polyaryletherketone ester, polyaryletherketone imine and polyaryletherketoxime, and the diversity and functionality of the material structure are expanded. Besides, through the hydrolysis reaction of the polyaryl ether ketone ester, the efficient recovery of the micromolecular benzoic acid compound is realized, and the potential of the strategy in the aspects of cyclic utilization and sustainability is embodied. According to the polymerization method based on Claisen condensation, a new way which is mild in condition, simple and convenient to operate and flexible in structure regulation and control is provided for synthesis of a functional degradable polyketone material.

The application relates to the technical field of organic synthesis, in particular to an alpha-arylaminoketone compound and a preparation method and application thereof. The preparation method comprises the following steps: reacting a halogenated alpha-aryl ketone compound I with an amine compound II in the presence of a base and a solvent to obtain an alpha-arylaminoketone compound III. The preparation method has simple and mild conditions, a wide selection range of reaction raw materials and high yield; the prepared alpha-arylaminoketone compound has high anticancer activity, and can be further modified by polypeptides and other drugs to expand the application range of disease treatment.

The invention discloses an organic photocatalyst based on an isothiatruxene skeleton as well as a preparation method and application of the organic photocatalyst. The preparation method of the organic photocatalyst comprises the following steps: by taking substituted or unsubstituted benzothiophene as a raw material, adding dichloro dicyanobenzoquinone, dropwise adding trifluoromethanesulfonic acid, and stirring at room temperature for 3-12 hours, or by taking substituted or unsubstituted benzothiophene and ninhydrin as raw materials, adding acetic acid and concentrated sulfuric acid, and reacting at 90 DEG C for 3-12 hours, thereby obtaining the photocatalyst based on the isothiatruxene skeleton. And adding hydrogen peroxide or m-chloroperoxybenzoic acid into the catalyst, and reacting at room temperature for 6-48 hours to obtain the photocatalyst based on the sulfoxide impurity or sulfone impurity isotruxene skeleton. The organic photocatalyst can catalyze a plurality of photooxidation reduction reactions under visible light, including carbonyl reductive coupling, alkyne oxidation, decarboxylation fluorination, toluene oxidation, amino heteroarylation of non-activated olefin, arone reductive deoxidation, styrene hydroformylation, styrene alkoxy acylation and aryl halide dehalogenation hydrogenation.

To provide an actinic-ray-curable ink composition having favorable fluidity and capable of imparting favorable dry-down and scratch resistance to a printed matter obtained by the use thereof while reducing the use of photopolymerization initiators by using monomers and oligomers that can be polymerized even without using a photopolymerization initiator and even while reducing the use of diallyl phthalate resin from an environmental perspective. The above-described problem is solved by an actinic-ray-curable ink composition comprising a component that is at least one polymer or resin selected from a polymer of allyl monomers, a rosin-modified resin, and a terpene monomer skeleton-containing resin, and a component that is a monomer and / or an oligomer having an amine functional group and / or both a monomer and / or an oligomer not having an amine functional group but having an aryl ketone skeleton or an alkyl aryl ketone skeleton, and a polyether acrylate having an amine functional group.

The invention provides a preparation method of a 2, 4-disubstituted quinazoline compound. The method comprises the following steps: by taking MV-10 (Mn) as a sole catalyst, firstly carrying out receptor-free dehydrogenation reaction on 2-amino aryl alcohol to obtain 2-amino aryl ketone, and then reacting the 2-amino aryl ketone with primary alcohol and ammonium salt to obtain the 2, 4-disubstituted quinazoline compound. According to the method, the 2, 4-disubstituted quinazoline compound can be efficiently catalyzed and synthesized by using MV-10 (Mn) as the catalyst through step-by-step catalysis without organic solvents such as methylbenzene and xylene, and ecological sustainable development is facilitated.

This invention belongs to the field of catalytic synthesis technology for fine chemical products, and discloses a method for photochemical reductive coupling of aryl α-keto esters to synthesize 2,3-diaryl tartrate esters. The method includes the following steps: in an inert atmosphere, the substrate aryl α-keto ester, an electron-sacrificing reagent, a proton-sacrificing reagent, and an organic solvent are mixed, and a selective reductive coupling reaction is carried out under visible light irradiation. After the reaction, 2,3-diaryl tartrate esters are obtained by separation and purification. This invention achieves the reductive coupling of aryl α-keto esters through a hydrogen transfer strategy, avoiding the use of hazardous hydrogen gas, eliminating the formation of reduction products, providing mild reaction conditions, and achieving high reaction yields, thus showing great application potential.

This invention discloses a method for preparing fluorinated aryl ketone compounds and their applications, relating to the field of organic synthesis technology. The method includes the following steps: using fluorinated olefins, benzoyl cyanates, and boric acid compounds as raw materials, and reacting them under visible light irradiation in the presence of a photocatalyst, a base, and an organic solvent to prepare fluorinated aryl ketone compounds. This invention uses fluorinated olefins as the key fluorinated substrate and achieves a multi-component synergistic reaction through visible light catalysis, solving problems such as substrate limitations, poor selectivity, and low yield in existing methods. The prepared fluorinated aryl ketone compounds can be used in the preparation of antibacterial, anti-inflammatory, and anticancer drugs, offering significant economic benefits.

The application discloses a ketone-containing arylamine polymer and a preparation method thereof, and belongs to the technical field of polymer chemistry. The main chain of the ketone-containing arylamine polymer contains a structural fragment shown in formula (I): formula (I); wherein R is selected from one of alkyl with 4-12 carbon atoms. The ketone-containing arylamine polymer introduces bulky aryl ketone structures on both sides of a nitrogen atom, forms a significant steric hindrance effect, meanwhile, the strong electron-withdrawing effect of the aryl ketone structures on both sides is achieved, and thus a fluorescent polymer with intrinsic acid resistance and oxidation medium stability is obtained.

The application is a new method for synthesizing p-terphenyl derivatives by cascade cyclization of aryl ketone multi-component form with dimethyl sulfoxide (DMSO) as two C sources under the promotion of potassium tert-butoxide. The method only uses strong base potassium tert-butoxide as a promoter, avoids the use of complex ligands and expensive metal reagents. At the same time, this formal [1+2+2+1] cascade cyclization reaction is suitable for a variety of substrates, has good tolerance to a variety of substituents, and can provide easily obtained p-terphenyl derivatives with good yield. In addition, the reaction also has the characteristics of low price of additives, simple reaction conditions, easy availability of starting materials, etc. The multi-component cascade cyclization protocol is realized by using easily commercially available starting materials at a lower cost, and a variety of substituted p-terphenyl compounds are synthesized.

The application discloses a triarylmethane dye for blue photoresist color paste and a synthesis method thereof. The dye is a triarylmethane dye P, which is prepared through the following steps: (1) dissolving an alkyl or aryl triamine MA in a solvent, adding a palladium catalyst, a ligand and an alkali, and reacting with an aryl halide under an inert atmosphere to obtain an intermediate IA; (2) dissolving a dihalogenated diaryl ketone MB in a solvent, adding a palladium catalyst, a ligand and an alkali, and reacting with a disubstituted amine under an inert atmosphere to obtain a target intermediate IB; and (3) condensing the intermediate IA and the intermediate IB to obtain a novel blue triarylmethane dye P. The triarylmethane dye has excellent color performance, is suitable for mixed or dye-based blue photoresist color paste, and can significantly improve the brightness, transparency, contrast and dispersibility of the color paste, and meanwhile, has high hiding power, strong coloring power, and good thermal stability and light stability. In addition, the synthesis method is simple in process and suitable for industrial production.