48 results about "Aryl ketone" patented technology

This invention relates to the field of anticancer drugs, and more particularly to an indole-3-aryl ketone derivative, its preparation method, and its applications. The indole-3-aryl ketone derivative is compound I-VI, which can be used to prepare drugs for the prevention and / or treatment of cancer, including at least one of breast cancer, liver cancer, lung cancer, colorectal cancer, leukemia, pancreatic cancer, glioma, osteosarcoma, cervical cancer, ovarian cancer, kidney cancer, and esophageal cancer. This invention screened the activity of various compounds and, for the first time, discovered that compound I-VI exhibits excellent inhibitory activity against multiple different types of human cancer cells, providing a potential option for broad-spectrum anticancer drugs.

The invention relates to the field of anti-cancer drugs, in particular to an indole-3-aryl ketone derivative as well as a preparation method and application thereof. The indole-3-aryl ketone derivative is a compound I-VI, the indole-3-aryl ketone derivative can be used for preparing drugs for preventing and / or treating cancers, and the cancers comprise at least one of breast cancer, liver cancer, lung cancer, colorectal cancer, leukemia, pancreatic cancer, glioma, osteosarcoma, cervical cancer, ovarian cancer, kidney cancer and esophageal cancer. According to the invention, activity screening is carried out on various compounds, the fact that the compounds I-VI have excellent inhibitory activity on various different types of human cancer cells is found for the first time, and an optional scheme is provided for broad-spectrum anti-cancer drugs.

The invention belongs to the technical field of asymmetric catalysis, and discloses a chiral phosphine nitrogen-nitrogen tridentate ligand based on a ferrocene skeleton as well as a preparation method and application of the chiral phosphine nitrogen-nitrogen tridentate ligand. The structural formula of the ligand is shown as (I) or an enantiomer (II) of the ligand. The preparation method comprises the steps of acylation reaction, oxazoline ring construction, aldehyde group introduction, reductive amination and the like, and application in asymmetric hydrogenation reaction, such as asymmetric hydrogenation of aryl ketone. The ligand has a plurality of chiral factors, simultaneously has a potential hydrogen bond donor, forms secondary interaction with a substrate in an asymmetric catalytic reaction, can further stabilize a reaction transition state, is an efficient novel chiral P, N, N-ligand, has the advantages of high reaction activity, good stereoselectivity, wide substrate range and the like, and has a wide application prospect. # imgabs0 #

The invention discloses a phosphorus-containing oxynitride compound based on a cycloarane skeleton and a ferrocene skeleton and a preparation method and application thereof, the phosphorus-containing oxynitride compound based on the cycloarane skeleton and the ferrocene skeleton is selected from at least one of compounds with structural formulas as shown in a formula I and a formula II, wherein Ar is independently selected from phenyl and C7-C15 substituted aryl; the substituent group of the substituted aryl group is selected from one of C1-C4 alkyl groups and methoxyl groups. According to the invention, a class of novel phosphorus-nitrogen-oxygen-containing compounds which have two planar chirality and are based on the cycloarane skeleton and the ferrocene skeleton can be effectively synthesized; as a ligand, the compound shows excellent catalytic activity and enantioselective control ability in asymmetric hydrogenation of an iridium-catalyzed N-aryl indolone compound or a heterobiaryl ketone compound.

The invention relates to the technical field of catalysts, in particular to a neutral nickel catalyst as well as a ligand, a preparation method and application thereof, and the ligand has a structure as shown in a formula I. According to the invention, a series of novel neutral nickel complexes with sandwich-like structures are developed based on an amide-aryl ketone skeleton structure for the first time; the series of catalysts are simple and efficient to synthesize, the ligand synthesis yield is greater than or equal to 80%, and the catalyst synthesis yield is greater than or equal to 80%; nuclear magnetic resonance monitoring shows that the nickel catalyst provided by the invention has high stability in air and does not deteriorate within 72 hours; during polymerization, no extra cocatalyst needs to be added, and the catalyst shows extremely excellent thermal stability and capability of inhibiting chain transfer side reaction in a solution copolymerization process and can resist poisoning of acrylate monomers at the same time.

The invention belongs to the technical field of medicines, and relates to application of an indole-3-aryl ketone derivative to preparation of a medicine for treating or preventing infectious diseases caused by staphylococcus aureus, in particular to application of the indole-3-aryl ketone derivative to preparation of a medicine for treating or preventing infectious diseases caused by drug-resistant staphylococcus aureus. The chemical structural formula of the indole-3-aryl ketone derivative disclosed by the invention is as shown in a formula I shown in the specification. Results of the invention show that the compound I (namely the indole-3-aryl ketone derivative as shown in the formula I) has strong inhibitory activity on methicillin-resistant staphylococcus aureus ATCC43300, the inhibitory effect is dependent on concentration gradient, the MIC50 value is 27.45 mu g / mL, and the MIC50 value of a positive drug streptomycin sulfate is greater than 200 mu g / mL. Therefore, the indole-3-aryl ketone derivative can be used for treating or preventing infectious diseases caused by the staphylococcus aureus.

The present application relates to the technical field of force-induced color-changing materials, in particular to an arylmethanone derivative containing a tetraphenylethylene and carbazole unit, a preparation method thereof and application thereof. The structural formula of the arylmethanone derivative containing a tetraphenylethylene and carbazole unit is shown in the following: after being subjected to an acting force, the arylmethanone derivative not only has obvious color change, but also has significantly increased fluorescence emission intensity, can realize high-contrast fluorescence recording, and can be widely applied to inkless writing.

There are many benefits to organometallic catalysis, especially in homogeneous catalysis for C(sp2)-H bond activation and new C-C bond formation reactions. These catalysts, which are mainly transition metal complexes with organic ligands, are very reactive and selective, which increases the range and effectiveness of different synthetic transformations. Their capacity to activate C-H bonds under mild reaction conditions is a key advantage as it allows for the direct C-H alkylation of aryl ketones without the need for transient functional groups. This reduces utilization of chemicals, cost and energy used in addition to streamlining synthetic routes. Furthermore, complex molecular architectures with high stereo- and regioselectivity may be formed with the help of organometallic homogenous catalysts, making precise synthesis of complex molecules possible. The present catalyst is easy to use, industrially scalable, recyclable, and provides excellent yields of C-H alkylated products from nonactivated alkyl halides. The reported methods need the use of excess (2-6 equivalent) of alkyl halides but this catalyst performs the catalytic reaction in the stoichiometric quantities of aryl ketone and alkyl halides.

The invention relates to a synthesis method of alpha chiral aryl ketone, and belongs to the technical field of chemical synthesis. The method comprises the following step: reacting a compound a, a compound b and a compound c in the presence of a catalyst, a ligand, alkali, silane and a solvent to obtain a compound d. The method has the advantages of high yield, high ee value and excellent technical effect.

A crosslinkable polyolefin formulation comprises (A) a polyethylene polymer and (B) an arylketone of formula (I) as defined herein; products made therefrom; methods of making and using same; and articles containing same.

The present invention provides processes for preparing intermediates for heteroaryl-ketone fused azanaphthane glucocorticoid receptor modulators and compositions with low impurity levels.

The invention relates to a chiral ferrocene skeleton PNNO tetradentate ligand and application thereof in asymmetric hydrogenation reaction. The ligand has the advantages of simple synthesis, good stability, high selectivity and the like. A metal complex of the ligand shows very excellent catalytic activity and extremely high enantioselectivity in an asymmetric hydrogenation reaction of ketone, can efficiently catalyze reduction of prochiral ketones such as aryl alkyl ketone, heteroaryl alkyl ketone, aryl (hetero) aryl ketone, aliphatic ketone and the like into corresponding chiral alcohol, and has huge industrial application potential.

A preparation method of aryl / heteroaryl ketone compounds, the present application relates to the technical field of organic photoelectric synthesis.The present application solves the technical problem that the existing reaction technology is difficult to realize in-situ activation of aryl / heteroaryl formic acid and dehydroxymethyl coupling of alcohol compounds to prepare aryl / heteroaryl ketone compounds.Method: the present application continuously carries out illumination in the reaction system and passes in constant current, takes carboxylic acid and alcohol compound as the reactants, the iron catalyst is excited by light at the anode, at the same time, in-situ activation of nickel catalyst and carboxylic acid occurs at the cathode, and then reduction elimination process is carried out to obtain aryl / heteroaryl ketone compounds.The electrons provided by the current in the system of the present application are used as cheap and clean oxidants, which avoids the use of external oxidants, the reaction operation is simple, the condition is mild, and the aryl / heteroaryl ketone compounds prepared by the present application are used in the field of medicine.

This invention discloses an age-resistant photochromic dye and its preparation method, belonging to the fields of fine chemical synthesis and optical functional materials technology. In this invention, naphthalene ketone is reacted with succinate and acetic anhydride to generate a hyperconjugated naphthol derivative. The naphthol derivative then reacts with the aforementioned hydroxyl-functionalized diarylkynyl alcohol to generate a hyperconjugated naphthopyran compound. This synthetic process is easy to operate. Furthermore, the obtained hyperconjugated naphthopyran compound exhibits a rapid fading rate and good age resistance, making it suitable for applications in photochromic lenses, textiles, anti-counterfeiting, coatings, and other fields.

The invention relates to an aryl ketone-based poly (aryl-alkylene) polymer electrolyte as well as a preparation method and application thereof, and belongs to the technical field of compound synthesis. The compound is obtained by carrying out functionalization reaction on aryl ketone polymers, the functionalization reaction is selected from one or more of quaternization reaction, sulfonation reaction and phosphorylation reaction; wherein x is any integer greater than or equal to 1, and y is an integer greater than or equal to 0; a and C are aryl structural units; and B and D are alkylene structural units obtained by reaction of ketone monomers. The aryl ketone-based poly (aryl-alkylene) polymer electrolyte has the advantages of high ionic conductivity, long service life, good mechanical property and the like. The preparation is simple, the reaction condition is mild, the operation is easy, the cost is low, and large-scale industrial production can be realized.

The invention discloses a preparation method and application of a fluorine-containing aryl ketone compound, and relates to the technical field of organic synthesis.The preparation method comprises the following steps that fluorine-containing olefin, a benzoyl cyanide compound and a boric acid compound serve as raw materials and react under visible light irradiation in the presence of a photocatalyst, alkali and an organic solvent, and the fluorine-containing aryl ketone compound is prepared; the fluorine-containing olefin is used as a key fluorine-containing substrate, multi-component synergistic reaction is realized through visible light catalysis, the problems of substrate limitation, poor selectivity, low yield and the like in an existing method are solved, and the prepared fluorine-containing aryl ketone compound can be used for preparing antibacterial, anti-inflammatory and anti-cancer drugs and has high economic benefits.

The invention provides a method for preparing a polysubstituted aromatic hydrocarbon compound from an aromatic ketoxime derivative and a product. Specifically, the method comprises the following steps: (i) under the catalysis of a palladium catalyst, carrying out palladium / norbornene catalyzed Catellai reaction on a compound as shown in a formula II and compounds as shown in a formula III and a formula IV to obtain a polysubstituted aromatic hydrocarbon compound as shown in a formula I; wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. According to the method disclosed by the invention, a plurality of substituent groups can be introduced to various aromatic rings, so that the substrate range can be greatly expanded, rapid structural modification of natural products and drug molecules is realized, and the method has a wide application prospect.

The application discloses a preparation method of aryl alpha ketone photoinitiator, and relates to the field of organic synthesis. Specifically, the method comprises the following steps: taking a compound shown in formula (I) or formula (II), morpholine or piperidine as a reactant, taking potassium carbonate as an acid-binding agent, and performing a reaction under the action of a catalyst; wherein the catalyst is a porous SiO2 loaded palladium-copper composite catalyst, the average particle size of the catalyst is 180-250 nm, and the weight ratio of palladium to copper is (92-98):(2-8). The application avoids using fluorine-containing compounds as reactants, thus no fluorine-containing wastewater is generated, energy is saved, the environment is protected, and the cost is low. In addition, the reaction condition is mild, and the yield is high.

A resin composition containing a polyaryl ketone, the resin composition containing a polysiloxane having a structure represented by formula (1), a peak corresponding to a cyclic siloxane being detected in pyrolysis GC / MS of the resin composition, and the content ratio of the polysiloxane in the resin composition being 0.25-1.25 mass%. (In formula (1), R1 and R2 each independently represent an alkyl group having 1-3 carbon atoms)

The application discloses a kind of catalyst based on hollow silicon nanocapsule load and its preparation method, application, it is related to catalytic agent and organic synthesis field.Catalyst based on hollow silicon nanocapsule load preparation method includes: copper, palladium is loaded to carbon nanospheres, and intermediate is formed;Intermediate, CTAB, catalyst, tetraethyl silicate are mixed hydrolysis, calcine under inert atmosphere, 350~450 DEG C 1~4h, calcine in oxygen-containing atmosphere, 350~450 DEG C 2~8h, and catalyst based on hollow silicon nanocapsule load finished product is obtained.The catalyst of the application has large reaction area, and is active, can reduce the reaction temperature of morpholine or piperidine substitution reaction in the preparation process of aryl alpha ketone photoinitiator, and improve product yield.

The present application belongs to the technical field of medicine, and relates to a use of an indole-3-aryl ketone derivative in preparation of a medicine for treating or preventing an infectious disease caused by Staphylococcus aureus, in particular, in preparation of a medicine for treating or preventing an infectious disease caused by drug-resistant Staphylococcus aureus. A chemical structural formula of the indole-3-aryl ketone derivative of the present application is shown as formula I. The results of the present application show that the compound I (i.e. the indole-3-aryl ketone derivative shown as formula I) exhibits strong inhibitory activity on methicillin-resistant Staphylococcus aureus ATCC43300, and the inhibitory effect is dependent on a concentration gradient, and the MIC 50 value is 27.45 ug / mL, while the MIC 50 value of the positive medicine, streptomycin sulfate, is greater than 200 ug / mL. Therefore, the indole-3-aryl ketone derivative can be used in treatment or prevention of an infectious disease caused by Staphylococcus aureus.

The invention discloses black polyimide with high ultraviolet light sensitivity as well as a preparation method and application thereof, belongs to the technical field of functional polymer materials, and solves the problem that polyimide in the prior art cannot have excellent masking capability and ultraviolet light sensitivity at the same time. The structural formula of the polyimide is as follows: # imgabs0 #, and a structural unit A is polyaryl ether or polyaryl ketone; the structural unit B is tetraphenyl cyclopentadiene biphenyl; the structural unit C is diphenylamine or biphenol; and n is a positive integer from 1 to 50. According to the invention, reasonable molecular structure design is carried out on polyimide to prepare the intrinsic high-ultraviolet photosensitive black polyimide, so that the intrinsic high-ultraviolet photosensitive black polyimide is subjected to photoisomerization after exposure.

The application discloses a cytochrome P450 monooxygenase P450PL2 mutant and application thereof in the field of biotechnology. The P450PL2 enzyme derived from the doderlein bacillus DS-1 is subjected to multiple rounds of directional modification through the technical means of iterative saturation mutation, and a P450PL2 mutant with improved asymmetric hydroxylation activity is obtained, and the corresponding amino acid sequence is shown as SEQ ID No. 3. The P450PL2 mutant can be applied to catalyze the asymmetric hydroxylation of aryl ketone compounds to synthesize S configuration chiral alpha-hydroxy ketone compounds. The reaction has strict regioselectivity and stereoselectivity, and the operation process is simple and efficient.

The application discloses an asymmetric bis-aryl ketone compound and a synthesis method thereof. The method uses aryl anhydride and aryl bromide as main raw materials, N,N dimethylacetamide as a solvent, 5mol% of bis(triphenylphosphine)palladium dichloride and 5mol% of ethylene glycol dimethyl ether nickel bromide as catalysts, 10mol% of 2-(dicyclohexylphosphine) 3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl and 5mol% of alpha,alpha,alpha-tripyridine as ligands, one equivalent of sodium sulfate as an additive, two equivalents of zinc powder as a reducing agent, is placed into a reaction container under a nitrogen atmosphere, heated to 40 DEG C, and reacted for 12 hours to obtain the asymmetric bis-aryl ketone compound I with high yield. The method has the advantages of simple operation, mild reaction condition, high yield, few additives, high selectivity and the like, and has certain feasibility for realizing industrial production.

This invention belongs to the field of compound drug technology. It relates to an N-aryl ketone acid cyanine compound with the structure of general formula (I), obtained by a dehydration condensation reaction of a ketone acid compound of formula (II) and a diphenylamine derivative of formula (III) upon heating. The product structure has a donor-acceptor-donor conjugated structure. These compounds are structurally stable, possess good light-harvesting ability, and under laser irradiation, simultaneously exhibit reactive oxygen species generation and photothermal conversion capabilities, combining photodynamic and photothermal properties. They are non-toxic to cells, have good biocompatibility, and can be used as photosensitizers in the combined photothermal and photodynamic therapy of tumors.

The application discloses a green synthesis method for preparing chiral alpha-amino ketone under illumination, and comprises the following steps: adding a nitroaromatic compound, an alpha-hydroxy aryl ketone compound, a boron reagent and a chiral phosphoric acid reagent into a solvent, and reacting under illumination of 427-440 nm for 1-24 hours. The application adopts a photocatalysis strategy, does not need to add an external photocatalyst, has mild reaction conditions, simple operation steps, is green and environment-friendly, has high enantioselectivity and good functional group tolerance. Blue LEDs are used as reaction energy sources, which are green and environment-friendly and have high energy utilization rate, and can efficiently realize conversion of light energy into chemical energy. The prepared chiral alpha-amino ketone can be widely used in the fields of medicine and synthetic industry, can effectively reduce economic cost, and is environment-friendly.

The invention relates to preparation and application of polyaryl ketone based on Claisen polycondensation and a functional derivative of the polyaryl ketone. The claisen polycondensation reaction is creatively applied to the synthesis of the polyaryl ketone material. Through precise design of reaction substrates, controllable construction of polymers with different microstructures is realized, and various polymers with clear structures such as linear polyaryl ether ketone, star-shaped polyaryl ketone and fluorescent polyaryl ketone are successfully prepared. Furthermore, through post-modification reactions such as Bayer-Villiger oxidation and ketoamine condensation, the polyaryletherketone is efficiently converted into a series of functional materials such as polyaryletherketone ester, polyaryletherketone imine and polyaryletherketoxime, and the diversity and functionality of the material structure are expanded. Besides, through the hydrolysis reaction of the polyaryl ether ketone ester, the efficient recovery of the micromolecular benzoic acid compound is realized, and the potential of the strategy in the aspects of cyclic utilization and sustainability is embodied. According to the polymerization method based on Claisen condensation, a new way which is mild in condition, simple and convenient to operate and flexible in structure regulation and control is provided for synthesis of a functional degradable polyketone material.

The application relates to the technical field of organic synthesis, in particular to an alpha-arylaminoketone compound and a preparation method and application thereof. The preparation method comprises the following steps: reacting a halogenated alpha-aryl ketone compound I with an amine compound II in the presence of a base and a solvent to obtain an alpha-arylaminoketone compound III. The preparation method has simple and mild conditions, a wide selection range of reaction raw materials and high yield; the prepared alpha-arylaminoketone compound has high anticancer activity, and can be further modified by polypeptides and other drugs to expand the application range of disease treatment.