49 results about "Haloketone" patented technology

A method for the formation of 3-alkylthiophenes or 3-arylthiophenes from 3-halothiophenes. More particularly, improvements on the Kumada coupling reaction for the production of 3-alkylthiophenes or 3-arylthiophenes by reacting a 3-halothiophene with an alkylmagnesiumhalide or arylmagnesiumhalide Grignard reagent in the presence of a catalyst and a 2-methyl tetrahydrofuran solvent. The 2-methyl tetrahydrofuran solvent allows for higher concentrations of the Grignard reagent with minimal or no dithienyl side product generation, achieving higher product yields and at a lower cost than other known methods.

The invention discloses a method for synthesizing a 1, 4-diketone compound without a catalyst. In the existence of alkali, the corresponding 1, 4-diketone compound is obtained by reacting silyl enol ether and alpha-haloketone by taking perfluoroalkyl alcohol as a solvent. By adopting the method for synthesizing the 1, 4-diketone compound, the raw materials are easily obtained, the cost is low, the reaction conditions are mild, the operation is simple and easy to control, the side reactions are few, the after-treatment is simple, the product yield is relatively high, and the solvent can be recovered and recycled, so that the production cost is greatly saved; the method has good environment protection benefit and economical benefit and is suitable for industrial large-scale production.

Disclosed herein are haloketone refrigerant or heat transfer fluid compositions that are useful in refrigeration or air conditioning apparatus or as heat transfer fluids. The compositions of the present invention are also useful in centrifugal compressor systems that employ two-stage compressors or single slab/single pass heat exchangers.

The invention relates to a bivalent copper complex containing a diphosphine ortho-position carborane ligand, a preparation method and application thereof. The copper complex is prepared by the following method of: adding an n-BuLi solution dropwise into an ortho-position carborane o-C2B10H12 solution, and carrying out stirring reaction, then adding halogenated phosphine for continuous reaction, adding copper acetate Cu(OAc)2 into the reaction system for continuous reaction, after the reaction is finished, performing separating to obtain the diphosphine ortho-position carborane ligand, and applying the copper complex to catalytic synthesis of a beta-carbonyl phosphine oxide compound. Compared with the prior art, the synthesis process has excellent selectivity and high yield, the copper complex can catalyze alpha-haloketone and phosphite to react to synthesize the beta-carbonyl phosphine oxide compound under the room temperature condition, and the reaction is efficient, green and environmentally friendly.

The invention relates to the technical field of pesticide chemistry, and provides a preparation method of an alpha-halogenated ketone compound. The preparation method comprises the steps: mixing terminal alkyne halide, an organic solvent, acid and water, and reacting to obtain the alpha-halogenated ketone compound. According to the preparation method provided by the invention, the terminal alkyne halide is directly reacted under the conditions of acid and water, and the use of a metal ion complex catalyst is avoided, so that the tedious operation of removing metal ions in the post-treatment process of the product is avoided, the whole process is simple and convenient to operate, green and environment-friendly, and the requirements of large-scale industrial production are met; and in addition, the method provided by the invention is high in raw material conversion rate, relatively high in product yield and purity, free of anhydrous and anaerobic operation and wide in substrate universality, and target molecules can be obtained from aliphatic, aromatic and other terminal alkyne halides at high yield. Furthermore, the preparation method provided by the invention is mild in reaction condition and easy to control.

Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of α,β-unsaturated or α-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile α,β-unsaturated or α-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

The invention relates to a preparation method of alpha-haloketone of a nebivolol intermediate of a formula II, an intermediate compound I for preparing the alpha-haloketone, and a preparation method of the intermediate compound I. The preparation method disclosed by the invention comprises the following steps: taking chromane-2-carboxylic acid as a raw material, carrying out a reaction with dihalide or disulfonate, so as to obtain chromane-2-carboxylate I; further carrying out a reaction with dihalomethane under the effect of organo-lithium, so as to obtain the nebivolol intermediate alpha-haloketone II. According to the method disclosed by the invention, the defect that the intermediate for producing the alpha-haloketone is high in cost and low in purity is overcome. Moreover, the methoddisclosed by the invention has the advantages of being simple in operation, environmentally friendly, convenient for industrial production and the like.

Process for the efficient production of alpha-haloketones, alpha-halohydrins and epoxides on an industrial scale. These methods include a decarboxylation of the reaction product between a carboxylic acid derivative of general formula (1) and a metal enolate prepared from an α-haloacetic acid of general formula (2) or an acceptable salt thereof to produce formula ( 3) A method for α-haloketones, a method for reducing α-haloketones (3) to produce α-halohydrins, and a method for treating α-halohydrins (11) with alkali to close the ring to produce epoxy compound method. The methods described above are particularly suitable for the production of the corresponding optically active α-haloketones, α-halohydrins and epoxides from α-amino acid derivatives. R1COA (1)

The present invention provides a poly-substituted furan preparation method, wherein alpha-halogenated ketone reacts with a beta-dicarbonyl compound under an alkali-free and solvent-free condition to obtain the poly-substituted furan compound. According to the present invention, the preparation method has characteristics of easily available raw materials, low cost, mild reaction conditions, simple and easily-controllable operation, less side reaction, simple post-treatment, high product yield, no requirement of any catalysts and solvents, substantially saved production cost, good environmental protection benefits and good economic benefits, and is suitable for the industrial large-scale production.

The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provides a novel halohydrin derivative serving as an important intermediate for the epoxy alcohol derivative. Furthermore, the present invention provides a process for producing an intermediate for a triazole antifungal agent by allowing a halohydrin to react with a triazole sulfonamide, the process including a small number of steps. A process for producing an optically active epoxy alcohol derivative includes allowing an optically active α-substituted propionate derivative to react with a haloacetic acid derivative in the presence of a base to prepare an optically active haloketone derivative, allowing the resulting haloketone derivative to react with an aryl metal compound to stereoselectively prepare a halohydrin derivative, eliminating a substituent for the hydroxy group of the halohydrin derivative, and performing epoxidation with a base. Furthermore, a process for producing an intermediate for a triazole antifungal agent includes allowing a halohydrin derivative to react with a triazole sulfonamide, the process including a small number of steps.

The invention relates to an in-situ recycling technology of amine during alpha-aminoketone production, in particular to a technology by which a certain amount of alkali compounds or other low-cost acid binding agents are added to bind with substituted halogen anions while amine compounds react with alpha-haloketone. By adopting the in-situ recycling technology, the using amount of amine compoundssuch as dimethylamine and the like can be greatly reduced and the atom economy is improved.