69 results about "Diaryl ketone" patented technology

The invention provides compositions that include crosslinking agents having multiple photoactivatable groups, such as diaryl ketones, or a diaryl ketone, such as benzophenone, and at least one polymerizable monomer, such as a zwitterionic monomer. The compositions are useful as surface coating agents that provide brush type polymeric coatings. These polymeric coatings can be used on medical devices, such as artificial joints, to reduce wear and tear between the components of the joint and thus reduce or eliminate debris generated by friction between the joint components.

The invention discloses an alcohol dehydrogenase, a gene thereof, a recombinant expression vector and a recombinant expression transformant respectively containing the gene, a recombinase of the alcohol dehydrogenase, and an application of the alcohol dehydrogenase in asymmetric reduction synthesis of chiral diaryl secondary alcohol as a catalyst, and belongs to the technical field of bioengineering. The alcohol dehydrogenase is from Kluyveromyces sp. CCTCCM2011385, has a carbonyl group reduction function, and also has a hydroxy group oxidation function. Extra addition of glucose dehydrogenase and other enzymes used for cofactor circulation is not needed when the alcohol dehydrogenase is used in the reduction of diaryl ketone into the chiral diaryl secondary alcohol as a biocatalyst, and the alcohol dehydrogenase has the advantages of high catalysis efficiency, mild reaction conditions, easy product recovery and low cost, so the alcohol dehydrogenase has very good application and exploitation prospect in the production of antihistamine medicines.

The patent describes a new class of ruthenium (II) complexes containing as ligands 2-(aminomethyl)pyridines and phosphines, proven to be extremely active catalysts in the reduction of ketones to alcohols via hydrogen transfer. By using 2-propanol as the hydrogen source with said ruthenium complexes, high yields of the corresponding alcohol can be rapidly obtained starting from linear and cyclic alkyl aryl, dialkyl and diaryl ketones. The conversion of ketones to alcohols can reach 100% if operating in a gaseous hydrogen atmosphere (2 - 3 standerd atmosphere). Where the phosphines used are optically active, starting from prochiral ketone compounds various types of optically active alcohols can be produced, being important intermediates in the pharmaceutical industry, in the agrochemical industry and for fine chemicals generally.

The invention provides, in one aspect, a brush seal comprising brush seal bristles made up of component brush seal filaments. The component brush seal filaments comprise a polyether ketone comprising structural units derived from a diaryl ketone and a diphenolic compound and having a glass transition temperature in excess of 100° C. In a particular embodiment, the component brush seal filaments comprise PEEK. The novel brush seals provided by the present invention present a number of advantages over conventional non-metallic brush seals comprising KEVLAR filaments, such as enhanced friction characteristics and greater stability to fluid lubricants comprising groups reactive with the amide moieties present in aramid filaments such as KEVLAR.

The invention discloses a compound based on diaryl ketone and an application of the compound in an organic electroluminescent device. The compound has the characteristics of difficult intermolecular crystallization, difficult aggregation and good film-forming ability, and a rigid group in the molecules can increase the thermostability of a material. The compound as a luminescent layer material is used in the organic electroluminescent device, the luminescent device using the compound has good photoelectric property, and is suitable for and satisfies requirements of a panel manufacture enterprise.

The invention discloses a method for synthesizing a diaryl ketone compound. Benzoic acid is taken as an acylation reagent; substituted benzene is subjected to Friedel-Crafts acylation reaction under the action of a solid acid catalyst, after the reaction is finished, the product is separated and purified to obtain the diaryl ketone compound, and then the solid acid catalyst is recovered; the solid acid catalyst is porous oxide loaded phosphorus pentoxide; and a carrier porous oxide of the solid acid catalyst is solid silica gel or aluminum oxide. The catalyst has the characteristics of high selectivity, high activity, easy regeneration and recycling, capacity of reducing waste discharge, and light pollution on the environment. The preparation method has the advantages of low cost, simple operation and industrial application value.

The invention discloses a compound based on diaryl ketone and an application thereof in organic electroluminescent devices. The compound has the characters that molecules are not liable to crystallize and aggregate and the compound has excellent film forming property. In addition, rigid groups in the molecules can improve thermal stability of the material. The compound is used on the organic electroluminescent devices as a luminescent layer material. The organic electroluminescent device using the compound has excellent photoelectric performance and can satisfy application requirements of panel manufacturers better.

The invention discloses an organic light emission diode device containing a diaryl ketone compound and an application thereof. The device comprises a hole transport layer, a light emission layer and an electron transport layer. The material of the light emission layer of the device comprises a compound comprising diaryl ketone, and the structural formula of the compound is shown in the general formula (1). According to the diaryl ketone material, due to a small triplet and singlet energy difference, energy transfer between host and guest materials can be realized easily, energy that is originally lost in a heat form is easily available, the radiative transition efficiency of the light emission layer is enhanced, and the high efficiency of the device can be acquired more easily. Further, when a fluorescent material is selected as a doped material, light emission radiation of the doped material is acquired more easily, and a long service life of the material can be acquired more easily.

The invention discloses a method for preparing diaryl ketone from aryl sulfonate. The method includes following steps: in the presence of a catalyst and carbon monoxide, allowing aryl sulfonate and aryl boronic acid to react in an organic solvent; after reaction is finished, performing aftertreatment to obtain diaryl ketone. Aryl sufonate is adopted as an electrophilic reagent for Suzuki cross carbonylation coupling reaction, diaryl ketone is directly synthesized through carbon monoxide, aryl sulfonate and aryl boronic acid, reaction conditions are milk, functional groups are high in tolerance, a substrate is cheap and easy to get, and diaryl ketone can be prepared with high yield.

The invention discloses a method for carbonylation synthesis of diaryl ketones through iron catalysis and belongs to the technical field of catalytic synthesis. According to the method, in a solvent alcohol or alcohol aqueous solution, and in the action of alkali, acid and iodide, an iron catalyst is added for catalyzing a direct cross-coupling reaction of an aryl halogenated compound, an aryl boron compound and a carbonyl source including haloform or carbon tetrahalide to prepare a diaryl ketone compound. The method for preparing a diaryl ketone compound through a coupling reaction is safe in carbonyl source and easy to treat and is cheap; the catalyst is available in sources and low in toxicity and is cheap; the reaction is free of ligand and good in activity; the reaction condition is mild and the selectivity is high; the substrates are available in sources and are stable; the functional groups of the substrates are good in compatibility and the substrates are wide in application range; and the reaction medium is green and can be reused. In an optimized reaction condition, the separation yield of a target product can reach 94%.

The invention relates to a visible light free radical and cation double-effect photosensitive initiator prepared from iron arene complexes and discloses application of benzene ligand iron arene complexes, taking diaryl ketone and derivatives thereof as substituent groups, as free radical and cation photoinitiators. The compounds have dual structures of a free radical type photoinitiator and a cation type photoinitiator, not only can be used for a visible light curing polymerization system of cation type and free radical type single curing mechanisms, but also can be used for a cation-free radical stray light curing polymerization system.

A photocrosslinkable composition has polyorganosiloxane P having a viscosity of at least 10 000 mPa·s at 25° C., wherein the polyorganosiloxane P has an acrylated silicone oil as a crosslinking agent, and a photoinitiator, the chemical structure of which comprises a diaryl ketone group.

The invention provides a catalytic oxidation synthesis method of a diaryl ketone compound. In an organic solvent, ester derivatives of diaryl methanol are used as reaction substrates, DDQ and TBN are used as catalysts, oxygen is used as an oxidant, so as to react for 1 to 12 h under the conditions of oxygen pressure of 0.1 to 0.4 MPa and temperature of 110 to 140 DEG C, and post processing is performed on reaction liquid, so as to obtain a product of the diaryl ketone compound; structural formulas of the ester derivatives of the diaryl methanol as the reaction substrates are shown in the formulas (V), (VI), (VII) or (VIII), and structural formulas of products which are correspondingly obtained one by one are shown in the formulas (I), (II), (III) or (IV). The catalytic oxidation synthesis method has the advantages of simplicity, convenience and safety in operation, mild reaction condition, high product selectivity and environmental friendliness.

The invention discloses an alcohol dehydrogenase mutant and application thereof in synthesis of chiral diaryl alcohol compounds. The alcohol dehydrogenase mutant disclosed by the invention is a protein, which is obtained through mutating amino acid residues located in a catalytic center pocket of alcohol dehydrogenase TbSADH, and particularly is the protein, which is obtained through mutating 39thand/or 42th and/or 84th and/or 85th and/or 86th and/or 104th and/or 110th and/or 294th amino acid residues of an amino acid sequence of the alcohol dehydrogenase TbSADH. According to the alcohol dehydrogenase mutant and the application thereof, the alcohol dehydrogenase TbSADH is subjected to enzyme reforming by applying an orthogenesis technology and method, a series of mutants, which have enzyme activity to diaryl ketones with represented by (4-chlorophenyl)pyrid-2-ketone, are obtained, and the mutants are applied to biocatalytic synthesis of optically-pure chiral diaryl alcohol compounds.

The invention discloses a one-pot method used for synthesis of diaryl methyl ketal. The on-pot method is shorter in process, and is more effective. A novel synthesis strategy is provided for synthesisof some complex diaryl ketones. According to the one-pot method, an aryl carboxylic acid and a R-substituted benzene compound are selected, in the presence of trifluoroactic anhydride, boron trifluoride diethyl etherate is taken as a catalyst, direct acylation reaction is carried out, without treatment, methanol and trimethyl orthoformate are added for continuous reaction so as to obtain a diarylmethyl ketal product, so that one-pot synthesis of diaryl methyl ketal from aromatic acids is realized.

The invention relates to a synthetic method for a diaryl ketone compound which can be used as a drug intermediate and is shown as a formula (III) which is described in the specification. The method comprises a step of reacting a compound (I) as described in the specification with a compound (II) as described in the specification in a nitrogen atmosphere and organic solvent in the presence of a catalyst, an oxidizing agent, alkali and a promoter so as to obtain the compound as shown in the formula (III). In the formula (III), R1, R2 and R3 are independently selected from a group consisting of H, C1-6 alkyl groups, C1-6 alkyloxy groups, halogen and nitro groups; and X is halogen. According to the method, through selection of an appropriate substrate and usage of a reaction system composed of the catalyst, the oxidizing agent, the alkali and the promoter, high yield of the target product, i.e., the diaryl ketone compound, is realized; and a brand novel synthetic method is provided for the compound, and the synthetic method has wide market application prospects.

The invention provides a synthetic method for diaryl ketone compounds. The method comprises the following steps: adding ester derivatives of raw material diaryl methanol, DDQ and water into an organic solvent, carrying out stirring, then carrying out heating to 110 to 140 DEG C and carrying out reaction for 0.5 to 12 h, and subjecting obtained reaction liquid to after-treatment so as to obtain the diaryl ketone compounds, wherein the ester derivatives of the raw material diaryl methanol have a structural formula as shown in a formula (V), (VI), (VII) or (VIII), and one-to-one correspondingly obtained products have the structural formula as shown in the formula (I), (II), (III) or (IV). The synthetic method for the diaryl ketone compounds provided by the invention has the advantages of simple, convenient and safe operation, mild reaction conditions and high product selectivity.

The invention discloses a synthetic method for sotagliflozin and its analogues. The method comprises the following steps: with dapagliflozin acetate 1 as a raw material, carrying out oxidation so as to obtain diaryl ketone 2; selectively removing an acetyl group in the compound 2 so as to obtain primary alconol 3; carrying out dehydroxymethyl fluorination so as to obtain fluoroglucoside 4; then subjecting a carbonyl group to reductive alkylation so as to obtain a compound 5; reacting an activated C-F bond and a nucleophilic reagent to obtain a glycosylation product 6a-6c; and finally removingan acetyl group so as to obtain sotagliflozin and its analogue 7a-7c, or subjecting the compound 5 to removal of the acetyl group to obtain a sotagliflozin analogue 7d. The synthetic method of the invention has the following advantages: the raw material dapagliflozin acetate can be prepared from inexpensive and easily available 1,5-gluconolactone; only the acetyl group is used as a protecting group which can be removed under mild conditions; a reducing agent sodium borohydride used in the method is cheap, easily available, and stable in water and air; stereoselective reduction is not involved,so the difficulty of synthesis is lowered, experimental operation is simplified, and the method is suitable for large-scale preparation.

The invention relates to the field of antitumor drugs and provides application of diaryl ketone compounds in preparation of the antitumor drug. The diaryl ketone compounds are compounds shown as formulas M11, M13, M14, M15, M-126, M128, M130, M131, M132 and M149. By antitumor activity research experiments, the compounds show anti-tumor cell proliferation activity with a certain degree, and most compounds show strong inhibition effect; the compounds can strongly inhibit the growth of tumor cells, can promote apoptosis at relatively-low concentration and show stronger inhibition effect compared with positive contrast compounds. The preparation process of the compounds is simple and feasible; raw materials are low in price and easy to obtain; an antitumor effect target of the compounds can be found by researching a structure-function relationship, and a valuable guiding function is provided for further research and development of the drugs. The diaryl ketone compounds disclosed by the invention provide a basis for screening new drugs.

The invention discloses a synthetic method of a diaryl methanol compound. Compared with a reported method for obtaining the diaryl methanol compound through catalytic reduction by taking diaryl ketone as an initial raw material, the method is characterized by taking substituted benzyl bromide and substituted phenylboronic acid which are cheap and easy to obtain as initial raw materials, reacting for 4 hours in an alkaline solution, water or a mixed solvent of the water and an organic solvent under room temperature in air, and carrying out simple separation and purification operation, thus obtaining a pure product. A catalyst adopted in the method is a palladium compound/an in-situ catalytic system prepared from phosphorus- and oxygen-containing carboxylic acids ligands, the catalytic system is cheap in price, high in catalytic activity and good in selectivity and is stable in the air and a water solution, the diaryl methanol compound is compounded through a method of catalyzing the substituted benzyl bromide and the substituted phenylboronic acid and a 'one-pot reaction method' of hydrogen peroxide, the reaction steps are less, after-treatment is simple, the product is easy to separate and purify, the yield is high, and the mixed solvent is prepared from cheap and easy-to-obtain water and the organic solvent, so that the environment is not polluted, and environment protection is realized.