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Tissue engineering complex grid shape stent forming method base on core dissolving technology

A technology of tissue engineering and mesh scaffolds, which is applied in the field of forming complex tubular mesh scaffolds in tissue engineering, can solve the problems of inability to form spatial mesh structures, complex tubular mesh scaffold forming methods, and limited types of formable materials, etc., to achieve Rapid forming, large processing capacity and wide range of applicable materials

Inactive Publication Date: 2005-08-17
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] The present invention aims at the problems of limited formable materials in the current tubular support technology, the inability to form a tubular support with a spatial network structure, and the inability to form a tubular support with a material gradient and a pore gradient in the tube wall, and develops a core-dissolving technology. Tissue Engineering Complex Tube-Network Scaffold Forming Method

Method used

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  • Tissue engineering complex grid shape stent forming method base on core dissolving technology
  • Tissue engineering complex grid shape stent forming method base on core dissolving technology
  • Tissue engineering complex grid shape stent forming method base on core dissolving technology

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Embodiment 1

[0035] In a certain tissue engineering, a tube network-like carrier tubular scaffold with a planar bifurcated structure is required. The maximum diameter of the "trunk" is 3mm, and there are two bifurcated structures under the trunk, and the bifurcation diameter is 3mm. The tube wall of the stent has a three-layer structure. The inner wall needs a microporous structure with a pore size of 70um, a porosity of about 90%, and the material is PLGA. The outer wall needs a microporous structure with a pore size of 120um, a porosity of about 75%, and the same material as the inner layer. The middle layer has no microporous structure, and the material is PCL-PET multi-block copolymer.

[0036] (1) Design the inner core of the stent. Use SolidWorks 3D CAD software to design the 3D structure of the inner core, and export the CAD model of the stent inner core as an STL file format.

[0037] (2) The inner core is made by melt extrusion process (MEM process). The core forming material ...

Embodiment 2

[0053] Three-dimensional block-like scaffolds with inner tube networks were prepared. The bracket has interconnected internal pipe network inside. The pipe network in the stent has a three-layer spatial bifurcation structure and four pipe diameters, the diameters of which are 1200 μm, 900 μm, 600 μm, and 300 μm in sequence. The shape of the inner pipe network is as image 3 shown. The manufacturing process of the bracket is as follows:

[0054] (1) According to the shape of the inner pipe network, use Solidworks software to design the inner core of the inner pipe network. According to the appearance and shape of the stent, design the outer contour and inner core of the stent. And export the obtained models as STL files respectively. The shape of the inner core of the inner pipe network is as follows: Figure 4 shown

[0055] (2) The inner core of the inner pipe network is formed indirectly based on the stereolithography process.

[0056] First, the inner core of the inn...

Embodiment 3

[0066] Preparation of common bile duct stent with planar bifurcation structure. The macroscopic structure of the stent is a main pipe with an inner diameter of 9mm, and two bifurcations with inner diameters of 8mm and 6mm are separated from the face. The tube wall requires no microporous structure, and the scaffold forming material is PLLGA.

[0067] (1) Design the inner core of the stent. Use SolidWorks 3D CAD software to design the 3D structure of the inner core, and export the CAD model of the stent inner core as an STL file format.

[0068] (2) Direct forming of the inner core based on the melt extrusion process.

[0069] The MEM250-II melt extrusion molding system produced by Beijing Yinhua Laser Rapid Prototyping and Mold Technology Co., Ltd. was used to make the outer contour support of the stent. The forming material is a mixture of maltose, glucose and sucrose. The main process parameters adopted are: layer thickness 0.20mm, scanning speed 23mm / s.

[0070] (3) 1 ...

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Abstract

The method of complicated tubular netted tissue engineering rack forming technology based on core dissolving technique belongs to the field of tissue engineering rack manufacturing technology. The technological process includes first designing 3D model of rack and rack core; making rack core with water soluble material without biotoxicity through fast laminated formation; compounding solution of biocompatible material with proper amount of pore creating agent and coating the solution onto the rack core; air drying, soaking in distilled water to dissolve out rack core and pore creating agent, taking out and volatilizing water and coating different forming material with or without pore creating agent successively to form the tubular netted rack with complicated spatial structure, different material gradient and different pore gradient.

Description

technical field [0001] The invention relates to a method for forming a tissue engineering complex tube mesh support, which belongs to the technical field of forming and manufacturing tissue engineering support. Background technique [0002] As one of the three elements of tissue engineering, tissue engineering scaffolds provide the material basis and mechanical support for cell growth, which is the basis for tissue engineering research. Human tissue engineering technology requires scaffolds to have good biocompatibility and degradability; have suitable mechanical properties; have a macroscopic morphology similar to the target organ and a certain microporous structure. The macroscopic shape of the scaffold basically determines the final shape of the artificial tissue or organ. Stents with pipe network structure as the main feature are needed in neural conduit repair, blood vessels, salivary glands, tissue engineering and other digestive tracts, respiratory tracts, urethras a...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61F2/04A61F2/06A61L27/00
Inventor 林峰颜永年张磊卢清萍王小红熊卓吴任东张人佶向虎陶梅
Owner TSINGHUA UNIV
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