Method for preparing medicine graded sustained-release bone repair body

A bone prosthesis, slow-release technology, applied in prostheses, medical science, bone implants, etc., can solve the problems of difficult to meet the different needs of growth factors, inactivation of growth factors, untimely drugs, etc. Cell attachment, good osteogenic repair, time-saving effect

Inactive Publication Date: 2012-10-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Method 1 is prone to sudden release of drugs, and the drugs are evenly mixed, resulting in untimely or premature loss of drugs, and it is difficult to meet the different needs of growth factors in different stages of bone repair
If composite materials are used as restoration materials, the organic materials need to be dissolved at high temperature and then formed, otherwise organic solvents need to be added, so for the second method, it is easy to cause the inactivation of growth factors

Method used

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  • Method for preparing medicine graded sustained-release bone repair body
  • Method for preparing medicine graded sustained-release bone repair body
  • Method for preparing medicine graded sustained-release bone repair body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] see Figure 1 to Figure 6 , a method for preparing drug graded slow-release bone prosthesis, comprising the following steps:

[0033] (1) Obtain the bracket matrix model:

[0034] Use Mimics software to reconstruct the Micro-CT scanning image of the femur, optimize the grid structure, select the cancellous bone part with uniform distribution of pores, and enlarge it by 5 times to increase the aperture of the model. figure 1 and figure 2 The three-dimensional structure shown is used as the matrix model of the inner layer of the stent and the matrix model of the outer layer of the stent;

[0035] (2) Design the negative model of the matrix: According to the shape of the support matrix, use Magics software to design the negative model of the matrix that matches the shape of the matrix model, such as image 3 and Figure 4 As shown, that is, corresponding to the stent inner layer matrix model and the stent outer layer matrix model obtained in the above step (1), design...

Embodiment 2

[0043]This embodiment is basically the same as Embodiment 1, especially in that:

[0044] In the above step (6), the stent assembly formed by assembling the inner matrix and the outer matrix of the stent is vacuum-dried at low temperature, and finally the finished bone prosthesis is obtained, which can effectively guarantee the sanitation and safety of the finished bone prosthesis.

Embodiment 3

[0046] This embodiment is basically the same as the previous embodiment, and the special features are:

[0047] In the above step (6), when the bone prosthesis slurry is poured into the inner matrix of the stent and the outer matrix of the stent, vacuuming and defoaming are carried out at the same time to reduce gas inclusions in the bone prosthesis, so that the pores of the stent matrix are filled with bone. The prosthetic slurry enables the bone prosthetic to play the role of drug graded slow release.

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Abstract

The invention discloses a method for preparing a medicine graded sustained-release bone repair body. The method comprises the following steps of: reconstructing a natural cancellous bone micro-computed tomography (micro-CT) scanned image to obtain a three-dimensional model by using Mimics software, and taking positions with uniform pore distribution as stent inner layer and outer layer matrix models through Boolean operation; designing inner layer and outer layer negative models of which the shapes are matched with those of the matrix models by using Magics software, and preparing through fused deposition modeling; and preparing slurry mixed with different medicines, grouting inner layer and outer layer stent matrixes, preparing a stent by a freeze drying process, and thus obtaining a finished bone repair body product. The bone repair body prepared by the method can meet the requirement of a stent material on structural strength and can be loaded with various medicines, the controlled release of the medicines is realized, a sustained-release effect is achieved, and bone repair is well induced and promoted.

Description

technical field [0001] The invention relates to a preparation method of a bone prosthetic body, in particular to a preparation method of a slow-release bone scaffold based on fusion deposition molding, which is widely used in the field of bone tissue engineering for repairing bone defects. Background technique [0002] Clinically, there are many repair methods for bone defects, among which the preparation of artificial bone restorations by tissue engineering is considered to be one of the most effective methods for bone repair in the future. Seed cells, scaffold materials and growth factors constitute the three elements of tissue engineering. [0003] At present, the scaffold materials used in tissue engineering are mainly divided into three types: inorganic materials, organic materials and composite materials. Among them, inorganic materials are similar to the inorganic structure and composition of bone tissue, and have excellent osseointegration and osteoconduction proper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/54A61F2/28
Inventor 林柳兰王志坤周丽萍胡庆夕方明伦
Owner SHANGHAI UNIV
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