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Keratoprosthesis optical center area and preparation method thereof and keratoprosthesis

A technology of artificial cornea and center area, applied in medical science, prosthesis, eye implants, etc., can solve the problems of low success rate of corneal receptor treatment, lack of donor cornea sources, etc., achieve good hydrophilic performance, visible light The effect of high transmittance and excellent optical performance

Inactive Publication Date: 2017-02-01
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, due to the lack of sources of donor corneas, only a very small number of patients with corneal diseases can receive donor cornea transplantation; on the other hand, due to various adverse reactions after keratoplasty, the success rate of corneal recipients is very low

Method used

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  • Keratoprosthesis optical center area and preparation method thereof and keratoprosthesis
  • Keratoprosthesis optical center area and preparation method thereof and keratoprosthesis
  • Keratoprosthesis optical center area and preparation method thereof and keratoprosthesis

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preparation example Construction

[0031] The embodiment of the present invention also provides a method for preparing the optical central zone of the artificial cornea, comprising the following steps:

[0032] Preparation of artificial cornea center material;

[0033] Soak the artificial cornea center material in a silane coupling agent solution, add a catalyst, and vibrate in an ultrasonic water bath in a closed environment for 1 to 2 hours to prepare an aminated artificial cornea center material;

[0034] Wash the aminated artificial cornea center material with deionized water for 3 to 8 times, then place it in a solution of a heparin derivative or a heparin-like derivative, and react at room temperature for 10 to 20 hours to obtain the optical center of the artificial cornea; take out The optical central area of ​​the artificial cornea is washed with phosphate buffer saline for 3 to 8 times.

[0035] In the method for preparing the optical central region of the artificial cornea provided by the embodiment ...

Embodiment 1

[0060] Preparation of the artificial corneal optical center zone:

[0061] (1) Mix polyvinyl alcohol, water, and organic solvent evenly in a mass ratio of 1:1:10, inject into the hollow part of the mold and extend it into a film of a certain thickness; freeze at -50°C, and freeze for 5 to 20 Thaw at room temperature for 1 to 4 hours, repeat freezing and thawing for 6 to 10 times, and finally obtain an impermeable gel film. (2) Soak the non-water-permeable membrane in sterilized water for 5-10 days, and change the water once a day to obtain the artificial cornea central area material. (3) Cut out an appropriate amount of polyvinyl alcohol hydrogel film and soak it into the prepared silane coupling agent (APTS) solution, add an appropriate amount of catalyst, and vibrate in an ultrasonic water bath for 1 to 2 hours in a closed environment to obtain aminated polyvinyl alcohol hydrogel film. (4) Wash the aminated polyvinyl alcohol hydrogel film with deionized water for 3 to 8 ti...

Embodiment 2

[0068] Preparation of the artificial corneal optical center zone:

[0069] (1) Mix polyvinyl alcohol, water, and organic solvent evenly in a mass ratio of 1:2:10, inject into the hollow part of the mold and extend it into a film of a certain thickness; freeze at -50°C, and freeze for 5 to 20 Thaw at room temperature for 1 to 4 hours, repeat freezing and thawing for 6 to 10 times, and finally obtain an impermeable gel film. (2) Soak the non-water-permeable membrane in sterilized water for 5-10 days, and change the water once a day to obtain the artificial cornea central area material. (3) Cut out an appropriate amount of polyvinyl alcohol hydrogel film and soak it into the prepared silane coupling agent (APTS) solution, add an appropriate amount of catalyst, and vibrate in an ultrasonic water bath for 1 to 2 hours in a closed environment to obtain aminated polyvinyl alcohol hydrogel film. (4) Wash the aminated polyvinyl alcohol hydrogel film with deionized water for 3 to 8 ti...

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Abstract

The invention belongs to the field of prosthesis materials, and provides a keratoprosthesis optical center area. The keratoprosthesis optical center area is a surface-heparinized keratoprosthesis center material, and the surface-heparinized keratoprosthesis center material comprises a keratoprosthesis center material and a chemical modifier; the chemical modifier comprises a silane coupling agent and a heparin derivative or heparinoid derivative with anti-adhesion performance. According to the keratoprosthesis optical center area, the surface of polyvinyl alcohol hydrogel is chemically modified with the heparin derivative or the heparinoid derivative, and the excellent hydrophilia and high electronegativity of the heparin derivative or the heparinoid derivative are utilized, so that the keratoprosthesis center material with the surface provided with or containing the heparin derivative or the heparinoid derivative shows cell adhesive resistance. In addition, the keratoprosthesis optical center area is good in optical performance, water storage performance, swelling property and hydrophilic performance and high visible light transmittance.

Description

technical field [0001] The invention belongs to the field of prosthetic materials, and in particular relates to an artificial cornea optical central area, a preparation method thereof, and an artificial cornea. Background technique [0002] Corneal disease is an ophthalmic disease with a high incidence and difficult treatment, and it is also the second most blinding ophthalmic disease after cataract. On the one hand, due to the lack of sources of donor corneas, only a very small number of patients with corneal diseases can receive donor corneal transplantation; on the other hand, due to various adverse reactions after keratoplasty, the success rate of corneal recipients is very low. Therefore, for corneal patients, the development of artificial corneas has brought new hope to patients who cannot receive keratoplasty in time and who have failed corneal transplantation. [0003] Most artificial corneas are composed of a porous skirt support material and an optical center, and...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/52A61L27/56A61L27/24A61L27/18A61F2/14
CPCA61L27/20A61F2/142A61F2210/00A61F2240/001A61L27/18A61L27/24A61L27/52A61L27/56A61L2430/16C08L89/00C08L5/10C08L29/04
Inventor 罗仲宽胡惠媛周莉许友群邓新旺沈铭成王泽巩周金生
Owner SHENZHEN UNIV
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