Artificial cornea optical center and its preparation method, artificial cornea

A technology of optical center and artificial cornea, applied in the direction of eye implants, etc., can solve the problems of calcium precipitation, cell adsorption, protein adsorption, etc., and achieve the effect of rich reaction system and good biocompatibility

Active Publication Date: 2019-04-23
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide an artificial cornea optical center and its preparation method, and artificial cornea, aiming to solve the problems of calcium precipitation, cell adsorption, and protein adsorption in the existing artificial corneal optical center after implantation , thereby increasing the light transmittance of the artificial cornea

Method used

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preparation example Construction

[0026] The embodiment of the present invention also provides the above-mentioned method for preparing the optical center of the artificial cornea, comprising the following steps:

[0027] mixing betaine derivative monomers, chain transfer agents, initiators, photoinducers, auxiliary agents and solvents, and stirring to obtain a mixed solution, and placing the mixed solution in a transparent device;

[0028] Soaking the artificial corneal optic central membrane in the mixed liquid;

[0029] The mixed solution is irradiated by LED lamp or fluorescent lamp for 10-48 hours, unreacted substances are removed by using deionized water, and the optical central membrane of the artificial cornea whose surface is modified by betaine derivatives is obtained.

[0030] The preparation method of the optical center of the artificial cornea provided by the embodiment of the present invention requires mild reaction conditions, and the reaction can be carried out at room temperature; the reaction...

Embodiment 1

[0037] (1) Mix sulfobetaine methacrylamide, azobisisobutylcyanide, eosin Y, dimethyl sulfoxide, and ethanol at a mass ratio of 8:1:1:0.5:5:50, and stir to make All substances are mixed evenly to obtain a colored, transparent liquid, which is poured into a transparent glass bottle; (2) the 100cm 2 The optical central membrane of the artificial cornea was soaked in (1) the prepared solution; (3) deoxygenated the solution by bubbling nitrogen gas for 1 hour, and irradiated by a 10W, 460nm LED lamp for 24 hours, and the distance between the sample and the lamp was 10cm, thus Obtain the artificial corneal optical central membrane modified by betaine derivative monomers; (4) remove redundant unreacted substances through dialysis in a large amount of deionized water, and obtain the artificial corneal optical media modified by betaine derivative monomers. Finished central membrane.

Embodiment 2

[0039] (1) Sulphonate betaine methacrylamide, 4-cyanopentanoic acid dithiobenzoic acid, 4,4'-azo (4-cyanopentanoic acid), eosin Y, dimethyl sulfoxide 1. Water is mixed according to the mass ratio of 5:0.5:1:0.5:10:100, and all the substances are mixed evenly by stirring to obtain a colored and transparent liquid, which is poured into a transparent glass bottle; (2) the 100cm 2The optical central membrane of the artificial cornea was soaked in (1) the prepared solution; (3) deoxygenated the solution by bubbling nitrogen gas for 10 minutes, and irradiated by a 10W, 460nm LED lamp for 18 hours, and the distance between the sample and the lamp was 10cm, thus Obtain the artificial corneal optical central membrane modified by betaine derivative monomers; (4) remove redundant unreacted substances through dialysis in a large amount of deionized water, and obtain the artificial corneal optical media modified by betaine derivative monomers. Finished central membrane.

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Abstract

The invention relates to the prosthesis material field, and provides a Keratoprosthesis optical central part and a preparation method thereof, and a keratoprosthesis; the Keratoprosthesis optical central part is a Keratoprosthesis optical central film; the surface of the Keratoprosthesis optical central film and a betaine derivative can form active controllable free radical polymerization, wherein the active controllable free radical polymerization is reversible-addition fracture chain transfer free radical polymerization. The Keratoprosthesis optical central part uses an active controllable free radical polymerization method to modify the betaine derivative monomer onto the surface of the Keratoprosthesis optical central film; the modified Keratoprosthesis optical central film is excellent in biology compatibility, anti-calcareous deposition, anti-bacterial and anti-cell adhesiveness performances, thus effectively solving the transparency dropping problems caused by optical central area back and forth propagation films after the Keratoprosthesis is implanted.

Description

technical field [0001] The invention belongs to the field of prosthesis materials, and in particular relates to an optical center part of an artificial cornea, a preparation method thereof, and an artificial cornea. Background technique [0002] Globally, corneal disease is the fourth leading cause of blindness after cataracts, glaucoma, and age-related macular degeneration. According to statistics from the American Association of Eye Banks, about 100,000 corneal transplants are performed each year in the world, half of which are completed in the United States, and about 13% of the cases fail, so a considerable number of failed patients need artificial corneal transplantation. Fuming. In my country, more than 10 million people need corneal transplants due to corneal and ocular surface diseases, and less than 5,000 patients receive corneal transplants every year. The severe scarcity of corneal resources, large area of ​​corneal scarring, deep vascularization, and transplant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/14
CPCA61F2/142
Inventor 罗仲宽周莉胡惠媛周金生沈铭成王泽巩许友群
Owner SHENZHEN UNIV
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