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Keratoprosthesis and manufacturing method thereof

A technology of artificial cornea and cornea, applied in the field of biomedical engineering, can solve the problems of poor suturability and achieve the effects of preventing separation, avoiding spontaneous dislocation, and simplifying implantation surgery

Active Publication Date: 2014-06-04
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the defects and deficiencies of the prior art, and provide an artificial cornea; the artificial cornea is an integrated enhanced artificial cornea, which can solve the problem of poor suturability in the prior art

Method used

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  • Keratoprosthesis and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 1g of dry fluffy silk fibroin and put it into a glass bottle, add 4g of formic acid dropwise, fully stir to dissolve, then add 5g of sodium chloride (particle size 50-100μm), and mix well with the silk fibroin solution to make a slurry; take an appropriate amount Put the mixture into a special mold for artificial corneal stent and mold it. Put the stent together with the mold into a beaker filled with absolute ethanol for soaking. After 5 minutes, replace it with another beaker filled with absolute ethanol. Continue soaking for 5 minutes before taking it out. ;The bracket blank is placed on a certain curved surface device, and a hole with a diameter of 4mm is drilled at the central beam position with the prepared ring knife.

[0047] Put the punched stent blank on the convex mold to dry, and drop the deoxygenated HEMA thermal polymerization solution on the surface, HEMA:BIS:AIBN=1:0.03:0.002, until the stent is completely wetted (the surface has no obviously liquid...

Embodiment 2

[0051] Take 1g of dry fluffy silk fibroin and put it into a glass bottle, add 6g of formic acid dropwise, fully stir to dissolve, then add 10g of potassium chloride (particle size 40-80μm), and mix well with the silk fibroin solution to make a slurry; take an appropriate amount Put the mixture into a special mold for artificial corneal stent and mold it. Put the stent together with the mold into a beaker filled with absolute ethanol for soaking. After 5 minutes, replace it with another beaker filled with absolute ethanol. Continue soaking for 5 minutes before taking it out. . The stent blank is placed on a certain curved surface device, and a hole with a diameter of 4mm is punched at the central beam position with the prepared ring knife.

[0052] The punched stent blank was placed on the convex mold to dry, and the deoxygenated HEMA thermal polymerization solution (HEMA:BIS:AIBN=1:0.03:0.002) was added dropwise to the surface until the stent was completely wetted (the surface...

Embodiment 3

[0056] Take 1g of dry fluffy silk fibroin and put it into a glass bottle, add 8g of formic acid dropwise, stir and dissolve it fully, then add 15g of sodium carbonate (particle size 30-80μm), and mix well with the silk fibroin solution to make a slurry; take an appropriate amount of the mixture Place it in a special mold for artificial corneal stents and mold it. Put the stent together with the mold into a beaker filled with absolute ethanol for soaking. After 5 minutes, replace it with another beaker filled with absolute ethanol. Continue soaking for 5 minutes before taking it out; The stent blank is placed on a certain curved surface device, and a hole with a diameter of 4mm is punched at the central beam position with a ring knife prepared in advance).

[0057] The punched stent blank was placed on the convex mold to dry, and the deoxygenated HEMA thermal polymerization solution (HEMA:BIS:AIBN=1:0.03:0.002) was added dropwise to the surface until the stent was completely wet...

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Abstract

The invention belongs to the field of biomedical engineering, and relates to a keratoprosthesis and a manufacturing method of the keratoprosthesis. The keratoprosthesis comprises a spherical-crown-shaped keratoprosthesis body optical function area and a spherical-zone-shaped supporting area, wherein the keratoprosthesis body optical function area is combined with the supporting area, and the joint part of the keratoprosthesis body optical function area and the supporting area, interlaced and converged, is of an integrated transition structure; the keratoprosthesis body optical function area is made of PHEMA hydrogel good in biocompatibility and light transmission, the supporting area is composed of a PHEMA porous scaffold evenly reinforced by fibroin fibers, and the keratoprosthesis body optical function area and the supporting area are naturally connected in an integrated mode. The results of cell tests and animal tests show that the keratoprosthesis is good in biocompatibility, histocompatibility and flexibility and resistant to tear, facilitates suture, supports biology heal between the cambium and a carina support, can stop aqueous fluid from leakage and infection and can effectively avoid spontaneity dislocation after a transplant.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and relates to an artificial cornea and a preparation method thereof; the artificial cornea is an integrated reinforced artificial cornea. Background technique [0002] At present, in clinical treatment, usually after repeated allogeneic corneal transplantation failures, or in the case of alkali burns, lack of tears, severe corneal vascularization, etc., the only way to finally save and restore vision is artificial corneal transplantation. [0003] The currently commonly used artificial cornea is made of optically transparent materials such as polymethyl methacrylate or quartz glass, or it is used as the central mirror column material, and then equipped with a certain skirt fixing bracket to form an artificial cornea device, which participates in the vision of the patient. repair. Under normal circumstances, the preparation method of the above-mentioned artificial cornea is complicated, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/14B29D11/02
Inventor 徐建江孙建国洪佳旭钟伟
Owner EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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