Medicament for treating breast cancer and preparation method thereof

Abstract

The invention discloses a medicament for treating breast cancer and a preparation method thereof. The medicament comprises a preparation which is prepared from 3-beta-oxygen-alpha-L-arabinofuranosyl-based-28-norepinephrine ursolic-12, 17-diene serving as a medicinal active ingredient and medicinal auxiliary materials. The medicament comprises 1 to 90 weight percent of the medicinal active ingredient and 10 to 99 weight percent of the medicinal auxiliary materials. The medicinal active ingredient has a structural formula shown in the specification. The preparation method for the medicament fortreating the breast cancer comprises the following steps of: (1) crushing sanguisorba carbon serving as a medicinal raw material; extracting and filtering repeatedly; and concentrating filtrate to obtain a liquid extract; (2) dispersing the liquid extract obtained in the step (1) with water; extracting the dispersed liquid extract with chloroform; and recovering a solvent from extract liquid under normal pressure or a reduced pressure to obtain an extract; (3) performing silica column chromatography separation on the extract obtained in the step (2); performing recrystallization on solid obtained by suction filtering to obtain the medicinal active ingredient of a compound; and (4) preparing the preparation by using 20 to 90 weight percent of the medicinal active ingredient and the balanceof the medicinal auxiliary materials. The medicament is used for treating the breast cancer, has a good treatment effect, and can replace oral Western medicament in a postoperative chemotherapy period.

Description

technical field [0001] The invention relates to medicine, which is a medicine for treating breast cancer and a preparation method thereof. Background technique [0002] Breast cancer is a disease with a high incidence rate. According to preliminary statistics, the incidence rate has gradually increased in the past 10 years. The current treatment methods for breast cancer are drugs and surgery. Most patients need surgical treatment. Chemotherapy after surgical resection of the tumor is a better treatment method. Regardless of drug treatment or drugs taken during chemotherapy after surgery, effective drugs are generally All are western medicines, but the side effects of western medicines are clinically proven to be very obvious. Although there are traditional Chinese medicines for treating breast cancer in the published data, there is no data showing that their curative effect is significant. Therefore, in order to reduce the toxic and side effects of breast cancer patients ...

AI Technical Summary

Problems solved by technology

The current treatment methods for breast cancer are drugs and surgery. Most patients need surgical treatment. Chemotherapy after surgical resection of the tumor is a better treatment method. Regardless of drug treatment or drugs taken during chemotherapy after surgery, effective drugs are generally Both are western medicines, however, the side effects of western medicines have been clinically proven to be very obvious

Although there are traditional Chinese medicines for treating breast cancer in the published data, there is no data showing that their curative effect is significant

Images