Application of chemotherapy-related gene expression characteristics in prediction of pancreatic cancer prognosis

A gene expression, pancreatic cancer technology, applied in the field of biomedicine, can solve the problem of incomplete chemical sensitivity

Active Publication Date: 2021-09-24
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high heterogeneity of pancreatic cancer, predicting postoperative chemosensitivity with only one biomarker with sufficient specificity is incomplete

Method used

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  • Application of chemotherapy-related gene expression characteristics in prediction of pancreatic cancer prognosis
  • Application of chemotherapy-related gene expression characteristics in prediction of pancreatic cancer prognosis
  • Application of chemotherapy-related gene expression characteristics in prediction of pancreatic cancer prognosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0053] 1. Research object:

[0054] The research object of this embodiment is the postoperative tumor tissue of 29 patients with pancreatic cancer, and the inclusion and exclusion criteria are as follows:

[0055] (1) No history of other malignant tumors;

[0056] (2) Never received cancer treatment before operation, and no metastasis was found before operation;

[0057] (3) There is no sign of infection or other inflammation before operation;

[0058] (4) Radical resection;

[0059] (5) The postoperative pathological diagnosis was pancreatic ductal adenocarcinoma.

[0060] 2. Research methods:

[0061] (1) Collect surgically resected tumor tissue samples from patients with pancreatic cancer. Part of the tissue is extracted with carbon tetrachloride, isopropanol, and absolute ethanol solution to extract tissue mRNA; part of the tissue is fixed with paraformaldehyde and embedded in paraffin to construct a tissue microarray chip.

[0062] (2) Collect clinicopathological in...

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Abstract

The invention relates to application of chemotherapy-related gene expression characteristics in prediction of pancreatic cancer prognosis, and belongs to the technical field of biological medicines. According to the application of chemotherapy-related gene expression characteristics in prediction of pancreatic cancer chemotherapy response, immune cell infiltration and prediction models, the gene expression levels of BCHE, ADH1A and TSN4 in postoperative tumor tissues of pancreatic cancer patients are detected; related gene expression characteristic scores are calculated as objective indexes to reflect pancreatic cancer chemotherapy drug sensitivity, tumor purity, tumor immune cell infiltration level and potential tumor biological behaviors, and are used for guiding postoperative chemotherapy and immunotherapy of pancreatic cancer patients and promoting individualized treatment of pancreatic cancer; and meanwhile, pancreatic cancer prognosis risk layering is carried out based on chemotherapy-related gene expression characteristics, better prediction efficiency is achieved, the pancreatic cancer patients can obtain more clinical net income, and the application is applied to accurate clinical judgment of the postoperative survival time of the pancreatic cancer patients.

Description

technical field [0001] The invention relates to the application of chemotherapy-related gene expression characteristics in predicting the prognosis of pancreatic cancer, belonging to the technical field of biomedicine. Background technique [0002] The latest global epidemiological survey shows that pancreatic ductal adenocarcinoma is one of the most lethal and aggressive malignant tumors, and its 5-year survival rate is less than 9%. Due to the insidious and asymptomatic onset, most patients lose the opportunity to undergo radical resection when they are diagnosed. Only <20% of patients have the opportunity to undergo surgical resection, but disappointingly, the 5-year survival rate is only 20-30%. In the treatment of pancreatic cancer, in addition to surgical resection, postoperative adjuvant chemotherapy has also shown a certain therapeutic effect, and modified FOLFIRINOX or gemcitabine-based regimens are widely accepted as the first-line drug method for postoperative...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118
Inventor 浦宁吴文川陈强达张继成殷瀚霖楼文晖
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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