Medicament for treating colon cancer and preparation method thereof

Abstract

The invention discloses a medicament for treating colon cancer and a preparation method thereof. The medicament is prepared from medicinal active ingredients and pharmaceutic adjuvant, wherein the medicinal active ingredients comprise 3 beta-hydroxyl-28-deletion-12,17(18)-diene ursane. The preparation method comprises the following steps of: (1) adding methanol or ethanol into crushed charred sanguisorba root serving as a medicinal raw material, filtering the mixture, concentrating filtrate under normal pressure or reduced pressure to obtain extractum liquidum; (2) dispersing the extractum liquidum obtained by the step (1) with water, and extracting with chloroform to obtain extractum; (3) carrying out silicagel column chromatographic separation on the extractum obtained by the step (2) recovering a solvent, placing the solvent to separate white powder out, filtering the mixture to obtain the 3 beta-hydroxyl-28-deletion-12,17(18)-diene ursane; and (4) preparing the medicament from 20 to 90 weight percent of the 3 beta-hydroxyl-28-deletion-12,17(18)-diene ursane, and the balance of the pharmaceutic adjuvant by a conventional preparation method. The medicament mainly treats non-metastatic symptoms of the colon cancer, has no toxic or side effects, and is used by matching postoperative chemotherapy so as to relieve pain of patients.

Description

technical field The invention relates to medicine, which is a medicine for treating colon cancer and a preparation method thereof. Background technique According to the reported statistical data, colon cancer is a common malignant tumor of the digestive tract, and the incidence rate is increasing at a rate of about 2% year by year. Meanwhile, drugs for the treatment of colon cancer are constantly being introduced to the market. Commonly used drugs in Western medicine mainly include: fluorouracil, mitomycin, nitrosourea and furan fluorouracil, etc. Commonly used drugs in traditional Chinese medicine mainly include Xiaoaiping Tablets, Zhenxiang Capsules, Xihuang Pills, Kangaiping Pills, Cinobufacin Oral Liquid, Compound Mylabris Capsules, etc. It has been clinically shown that although some western medicines have better curative effect, they have a strong stimulating effect on the gastrointestinal mucosa, and have greater damage to the liver and kidney, especially long-term u...

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Problems solved by technology

It has been clinically shown that although some western medicines have better curative effect, they have a strong stimulating effect on the gastrointestinal mucosa, and have greater damage to the liver and kidney, especially long-term use of the patient's own immunity is also greater; the side effects of traditional Chinese medicine However, the curative effect is not good; whether it is treating non-metastasis of colon cancer or multiple metastases of colon cancer, the clinical effect is very little, so surgery is the main choice for patients, but the period of chemotherapy after surgery is generally All combined use of Western medicine for the treatment of colon cancer, therefore, bring greater pain to patients

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