Method for realizing chemosensitivity influence on laryngeal carcinoma cell lines by iron-carbon nanoparticle mediated cisplatin

A nanoparticle and cancer cell technology, applied in the field of clinical medicine, can solve laryngeal cancer radiotherapy and chemotherapy sensitivity, poor quality of life, dyspnea and other problems
CN104450855AInactive Publication Date: 2015-03-25朱力
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
朱力
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for realizing chemosensitivity influence on laryngeal carcinoma cell lines by iron-carbon nanoparticle mediated cisplatin. The method comprises preparation of iron-carbon nanoparticles, loading of cisplatin by the iron-carbon nanoparticles as well as influence of iron-carbon nanoparticle mediated cisplatin on laryngeal carcinoma Hep-2 cell microstructure, proliferation activity as well as Survivin mRNA (messenger ribonucleic acid) and caspase3 mRNA expression. According to the invention, the magnetic nano material is adopted for the first time to load cisplatin, a chemotherapeutic drug with higher magnetism and targeting is provided, the preoperative chemotherapeutic effect on laryngeal carcinoma can be improved after the drug is applied to clinical practice, the necessary and efficient chemotherapeutic drug is provided for functional laryngeal carcinoma radical treatment is provided, and the drug can be applied to postoperative chemotherapy simultaneously; and toxic and side effects of the chemotherapeutic drug are reduced, the iron-carbon nano material has high drug loading capacity, stable release rate and higher targeting, and the iron-carbon nanoparticle mediated cisplatin can play an important role in clinical popularization and application for laryngeal carcinoma treatment.
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Description

technical field

[0001] The invention belongs to the technical field of clinical medicine, and in particular relates to a method for mediating the influence of cisplatin on the chemosensitivity of laryngeal cancer cell lines by iron-carbon nanoparticles. Background technique

[0002] Laryngeal cancer is one of the common malignant tumors in ENT surgery. Although significant progress has been made in the treatment of malignant tumors in recent years, the postoperative recurrence of patients with laryngeal cancer and the decline in postoperative laryngeal function are still the bottlenecks in the treatment of laryngeal cancer. Surgery-based comprehensive treatment is the main treatment mode for laryngeal cancer. In recent years, with the introduction of the concept of functional laryngeal cancer surgery, the scope of surgical resection of laryngeal cancer tends to be reduced. Preoperative and postoperative radiotherapy and chemotherapy play an increasingly prominent role in red...

Claims

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