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Modified bamboo fiber enhanced chitosan-based porous material and preparation method thereof

A technology of porous materials and bamboo fibers, which is applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of unreported research on porous materials, and achieve the effect of being suitable for large-scale production, low cost and wide source.

Active Publication Date: 2019-12-27
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For chitosan-based porous materials, there is no report on the reinforcement of bamboo fibers to prepare porous materials.
And based on ionic crosslinking, if the surface carboxylated bamboo fiber is blended with chitosan solution, the mechanical properties and degradation performance of chitosan may be better improved, and the research on its porous materials has not been reported.

Method used

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  • Modified bamboo fiber enhanced chitosan-based porous material and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Take 5.0 g of chitosan (90% degree of deacetylation, molecular weight of 200,000), add 200 ml of deionized water, and then add 4.0 g of modified bamboo fibers with a length of 1 mm and a diameter of 0.2 mm, At the same time, 1.0 g of nano-hydroxyapatite ultrasonically dispersed in 100 ml of water was added dropwise to the above-mentioned bamboo fiber / chitosan mixture. After continuing ultrasonic magnetic stirring for 4 hours, 6 ml of glacial acetic acid was added to obtain the bamboo fiber / nano-hydroxyapatite / chitosan ternary composite gel. Freeze in a -20°C freezer for 48 hours. Freeze-dry to constant weight with a freeze dryer. Then it was soaked in 10% NaOH solution for 30 minutes, washed until neutral, and dried. Cut it into a block material of 10 mm×10 mm×10 mm, the measured compressive strength is about 1.5 MPa, the porosity is 82%, and the average pore diameter is 250 um; soaked in simulated body fluid in vitro for 4 weeks, there are a lot of The bo...

Embodiment 2

[0017] Embodiment 2: Take by weighing 4.0 g chitosan (deacetylation degree 95%, molecular weight is 300,000), add 200 ml deionized water, then add 3.0 g length is 1 mm, diameter is 0.2 mm modified bamboo fiber, At the same time, 3.0 g of bioactive glass ultrasonically dispersed in 100 ml of water was added dropwise to the above-mentioned bamboo fiber / chitosan mixture. After continuing ultrasonic magnetic stirring for 4 h, 6 ml of glacial acetic acid was added to obtain the bamboo fiber / bioactive glass / chitosan ternary composite gel. Place in a -20°C freezer for 48 hours. Freeze-dry to constant weight with a freeze dryer. Then it was soaked in 5% NaOH solution for 30 minutes, washed until neutral, and dried. Cut it into a block material of 10 mm×10 mm×10 mm, the measured compressive strength is about 2.2 MPa, the porosity is 75%, and the average pore diameter is 200 um; soaked in simulated body fluid in vitro for 4 weeks, there are a lot of The bone-like apatite is deposited...

Embodiment 3

[0018] Embodiment 3: Weigh 3.0 g chitosan (deacetylation degree 90%, molecular weight is 250,000), add 300 ml deionized water, then add 5.0 g length is 1 mm, diameter is 0.2 mm modified bamboo fiber, At the same time, 2.0 g of calcium phosphate ultrasonically dispersed in 100 ml of water was added dropwise to the above-mentioned bamboo fiber / chitosan mixture. After continuing ultrasonic magnetic stirring for 4 hours, 8 ml of glacial acetic acid was added to obtain the bamboo fiber / calcium phosphate / chitosan ternary composite gel. Place in a -20°C freezer for 48 hours. Freeze-dry to constant weight with a freeze dryer. Then it was soaked in 8% NaOH solution for 30 minutes, washed until neutral, and dried. Cut it into a block material of 10 mm×10 mm×10 mm, the measured compressive strength is about 2.0 MPa, the porosity is 78%, and the average pore diameter is 200 um; soaked in simulated body fluid in vitro for 4 weeks, there are a lot of Bone-like apatite deposition, the com...

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Abstract

The invention discloses a modified bamboo fiber enhanced chitosan-based porous material and a preparation method thereof. The porous material is prepared by ultrasonically stirring modified bamboo fibers and a compound of chitosan and inorganic particles in an aqueous solution, then performing uniform mixing, then adding a small amount of glacial acetic acid to obtain a compound gel substance, putting the compound gel substance in a culture dish, pre-cooling the compound gel substance and then performing lyophilization. Because carboxyl with the surface-modified bamboo fibers and cations of chitosan acidic solutions have a strong ionic crosslinking effect, compared with a porous material with non-modified bamboo fibers or without the bamboo fibers, the porous material disclosed by the invention has the advantage that the mechanical performance and the degradation performance are greatly improved. The novel porous material disclosed by the invention has the advantages that the used rawmaterials are rich in sources, and the preparation method is simple; and through content of the components of the porous material, the mechanical performance, the degradation performance, the osteoconductivity and the antibacterial performance of the porous material are regulated and controlled, and the porous material is expected to be used as a bone tissue engineering scaffold material.

Description

technical field [0001] The invention relates to a modified bamboo fiber reinforced chitosan-based porous material and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The use of porous materials as scaffold materials for bone tissue engineering is a key issue in bone tissue engineering research. An ideal scaffold material for bone tissue engineering should not only have good biocompatibility and three-dimensional porous structure, but also have certain mechanical strength to maintain the stress of bone tissue regeneration, and also have certain osteoconductivity and osteoinductivity. and an appropriate degradation rate. In order to obtain an ideal bone tissue engineering scaffold material, it is difficult to meet the above performance requirements if only a single material is used. Therefore, the composition and structural characteristics of natural bone are usually imitated, and the inorganic / polymer composite scaf...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/02A61L27/10A61L27/12A61L27/20A61L27/54A61L27/56A61L27/58
CPCA61L27/36A61L27/20A61L27/12A61L27/10A61L27/025A61L27/56A61L27/58A61L27/54A61L2430/02A61L2300/232A61L2300/404C08L5/08
Inventor 唐硕蒋柳云马兵利汤春燕苏胜培
Owner HUNAN NORMAL UNIVERSITY
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