10 results about "Antimetabolite" patented technology

To provide a method for treating the target cancer. [Solution] A method for treating a target cancer, comprising administering a bispecific antibody having binding specificity to EGFR and HER3 and a therapeutic agent to the target, wherein the therapeutic agent includes a tyrosine kinase inhibitor (TKI), an alkylating agent, an antimetabolite, a microtubule inhibitor, an anti-cancer antibiotic, a topoisomerase inhibitor, a chemoprotective agent, or a combination thereof.

To provide a gamma-polyglutamate oxidase folate antagonist composition that can overcome pharmacological challenges related to dose-limiting toxicity and therapeutic resistance associated with folate antagonist therapy. [Solution] A liposome composition (Lp-γPANTIFOL composition) containing a gamma polyglutamine oxidized folate antimetabolitic agent, wherein the gamma polyglutamine oxidized folate antimetabolitic agent contains 2 to 15 glutamyl groups, and the liposomes are pegylated.

The present application provides an antibody-drug conjugate, a method for preparing same, and use thereof. The antibody-drug conjugate has a structure of formula I. The drug is selected from a topoisomerase inhibitor, a DNA-damaging agent, a microtubule inhibitor, an RNA polymerase inhibitor, and an antimetabolite. The prepared antibody-drug conjugate has an optimized drug-to-antibody ratio and targeted killing effects against breast cancer, gastric cancer, lung cancer, and colorectal cancer.

To provide an alpha polyglutamated antifolate composition capable of overcoming pharmacological challenges associated with dose-limiting toxicity and treatment resistance related to antifolate therapy.SOLUTION: There is provided a liposomal composition comprising a liposome encapsulating an alpha polyglutamated antifolate, wherein the alpha polyglutamated antifolate comprises 2 to 15 glutamyl groups linked via alpha-carboxyl group bonds, wherein the liposome is pegylated, and comprises a targeting moiety having specific affinity for a surface antigen of a desired target cell.SELECTED DRAWING: None

The present invention provides methods, devices, and kits related to treatment of urothelial carcinomas of the lower tract with antimetabolite (such as gemcitabine). In some aspects the methods, devices and kits relate to treatment of urothelial carcinomas of the lower tract with an antimetabolite (such as gemcitabine) and an immunomodulating agent.

To provide gamma polyglutamated antifolate compositions to overcome pharmacological challenges associated with antifolate therapy, the dose-limiting toxicities and treatment resistance.SOLUTION: Disclosed is a liposome composition comprising a gamma polyglutamated antifolate (Lp-γPANTIFOL composition), where the gamma polyglutamated antifolate comprises 2-10 glutamyl groups, the liposome is PEGylated, and the liposome composition comprises a targeting moiety that has a specific affinity to a surface antigen on a target cell of interest.SELECTED DRAWING: None

Providing pharmaceutical compositions for the treatment of melanoma. [Solution] A pharmaceutical composition comprising (a) an LXRβ agonist selected from the following compounds 1, 2, 12, and 25, and / or a salt thereof, and (b) an antiproliferative compound selected from immunomodulators, topoisomerase inhibitors, antimetabolites, angiogenesis inhibitors, tyrosine kinase inhibitors, alkylating agents, and mitotic inhibitors. TIFF2026062949000078.tif110166

A method of treating hematological cancer comprising administering to a patient in need thereof a therapeutically effective amount of a phosphatidylinositol 3-kinase gamma (PI3Kg) inhibitor and an antimetabolite, optionally a therapeutically effective amount of a BCL-2 inhibitor. A method of identifying hematological cancer patients susceptible to treatment with a PI3Kg inhibitor. A method of treating hematological cancer, the method comprising administering to a patient in need thereof a therapeutically effective amount of a p-21 activated kinase 1 (PAK-1) inhibitor, optionally a therapeutically effective amount of a BCL-2 inhibitor.

Disclosed are compositions and methods for inducing pterygium regression from the visual axis / corneal center, stabilizing pterygium, treating hyperemia and symptoms in pterygium patients, and treating pterygium recurrence after pterygium resection. The method comprises administering a multi-kinase inhibitor, an antimetabolite, or a combination thereof to a patient requiring the method.

The present invention provides compositions and methods for inducing pterygium regression from the visual axis / corneal center, stabilizing pterygium, treating hyperemia and symptoms in pterygium patients, and treating pterygium recurrence after pterygium excision. [Solution] A method for inducing pterygium regression from the visual axis / corneal center, comprising administering a therapeutically effective amount of (1) a multikinase inhibitor; (2) an antimetabolite that inhibits epithelial cell proliferation and fibroblast proliferation; or (3) a combination thereof to the affected eye of a subject requiring treatment.