Deformable stimuli responsive material and preparation method thereof and stimuli responsive flexible microelectrode array

A stimuli-responsive and thermal-responsive technology, applied in the field of biomedical engineering, can solve the problems of delamination between the responsive layer and the flexible substrate, high trigger temperature, and limitations in practical applications

Active Publication Date: 2017-08-11
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the trigger temperature of the shape-memory polymer is close to 100°C, which is too high. At the same time, no chemical modification is used between the response layer and the...

Method used

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  • Deformable stimuli responsive material and preparation method thereof and stimuli responsive flexible microelectrode array
  • Deformable stimuli responsive material and preparation method thereof and stimuli responsive flexible microelectrode array
  • Deformable stimuli responsive material and preparation method thereof and stimuli responsive flexible microelectrode array

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] A deformable stimuli-responsive material, which is composed of a heat-responsive material, the heat-responsive material is polyisopropylacrylamide, the deformable stimuli-responsive material has a local Young's modulus difference, and the local Young's modulus The difference is brought about by the difference in cross-linking degree of the region. The deformable stimulus-responsive material is a thermoresponsive hydrogel with a thickness of 1mm.

[0070] The preparation method of the deformable stimulus response material comprises the following steps:

[0071] (1) Dissolve 0.9156g of isopropylacrylamide and 97mg of methylene bisacrylamide in 10mL of water and mix well, then add 125μL of photoinitiator diethoxyacetophenone, and the prepolymer solution is obtained after the solution is mixed evenly ;

[0072] (2) if figure 1 As shown, the pre-poly solution is injected into the mold, and the mold is composed of two pieces of glass and a polytetrafluoroethylene frame with...

Embodiment 2

[0075] A deformable stimuli-responsive material, which is composed of photothermal responsive materials composed of two groups of A and B. Part of the deformable stimuli-responsive material is composed of photothermal responsive materials composed of group A, and part of the region is composed of photothermal responsive materials composed of group B. The composition of the photothermoresponsive material, specifically, the composition of group A includes thermosensitive polymers (specifically polyisopropylacrylamide and poly(N-ethylacrylamide)) and photothermal nanoparticles (specifically gold nanorods ), group B consists of thermosensitive polymers (specifically poly(N-ethylacrylamide)) and photothermal nanoparticles (specifically gold nanorods), in the composition of A and B groups, the photothermal nano The weight percent content of the particles is 5%, and the deformable stimulus-responsive material has a local difference in Young's modulus, and the difference in local Young...

Embodiment 3

[0082] A deformable stimuli-responsive material specifically includes a temperature-sensitive polymer (specifically polyisopropylacrylamide) and magnetocaloric nanoparticles (specifically ferric oxide), and the content of the magnetocaloric nanoparticles is 5% by weight. %, the deformable stimuli-responsive material has a local difference in Young's modulus, the local Young's modulus difference is brought about by the alignment of ferric oxide nanoparticles, and the deformable stimuli-responsive material has a thickness of 500 μm Magnetothermal responsive hydrogels.

[0083] The preparation of the deformable stimuli-responsive material is regulated by an external magnetic field, so that the rigid iron ferric oxide nanoparticles are oriented along the long axis in the pre-polymerization solution of isopropylacrylamide, and then a composite gel is formed by irradiation polymerization , the directional arrangement of rigid iron ferric oxide in the flexible hydrogel material bring...

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Abstract

The invention provides a deformable stimuli responsive material which has local Young modulus differences. The deformable stimuli responsive material is formed by at least one of a thermal response material, a photo-thermal response material, a magnetic thermal response material, an electric heating response material, a humidity response material and a pH response material. The deformable stimuli responsive material can be converted into a three-dimensional structure from a plane two-dimensional structure under one or more outside stimuli conditions of temperature, light, magnetism, electricity, humidity and pH. The material is modified to the back of a planar flexible microelectrode array, so that three-dimensional deformation of the flexible microelectrode array can be implemented through outside stimuli, and precise control over controllable shaping and curvature of the conventional planar flexible microelectrode array can be implemented by further regulating the thickness or crosslinking degree and the like of the stimuli responsive material. The invention further provides a method for preparing the deformable stimuli responsive material and a stimuli responsive flexible microelectrode array.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a deformable stimulus-responsive material, a preparation method thereof, and a stimulus-responsive flexible microelectrode array. Background technique [0002] Flexible microelectrode arrays help patients perform functional reconstruction by applying pulsed current stimulation to specific nerve tissues, and have been widely used in medical devices such as cochlear implants and artificial retinas. As the direct contact point between the prosthesis and the nerve, the flexible microelectrode array plays a key role in the nerve electrical stimulation function of the prosthesis. The degree of fit between the microelectrode array and the nerve tissue or organ determines the effectiveness of electrical stimulation. However, the nerve tissue or organ is often an irregular curved surface, and traditional planar electrodes do not make good contact with it, resulting in low ...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F222/38C08F220/28C08F220/06C08L33/24C08L33/14C08L33/12C08L5/12C08K3/08C08K3/22C08K3/04C08K7/24A61N1/05
CPCA61N1/0541A61N1/0543C08F220/06C08F220/28C08F220/282C08F220/54C08K3/04C08K3/22C08K2003/2275C08L5/12C08L33/12C08L33/24C08L2203/02C08L2205/025C08F222/38C08K3/08C08L33/14C08K7/24
Inventor 杜学敏崔欢庆
Owner SHENZHEN INST OF ADVANCED TECH
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