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Temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof

A stimuli-responsive, intelligent polymer technology, applied in the field of polymer microcapsules and its preparation, can solve the problems of single-stimuli-responsive changes, and achieve the effects of uniform hollow size, convenient use, and uniform particle size

Inactive Publication Date: 2010-09-22
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reported smart polymer microcapsules have the patent No.01129003.X of Chu Liangyin et al. They are composed of porous microcapsule walls, environmental information sensing type switch valves arranged in each channel on the capsule wall and located in the capsule wall. In order to ensure the normal operation of the "pump", the volume changes of the environmental information-sensing particles in the capsule wall and the environmental information-sensing switch valves in the capsule wall must be opposite, because these limit, so this method can only achieve a single stimulus response change

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Mix 2g TEOS, 5g deionized water, 1g ammonia water and 80g ethanol evenly, and stir at room temperature for 48 hours at a stirring speed of 300 rpm. Subsequently, 0.3 g of 3-trimethoxysilylpropyl methacrylate was added, and stirring was continued for 48 hours at a stirring speed of 300 rpm to form a modified silica nanoparticle aqueous dispersion.

[0031] Use the above-mentioned modified silica nanoparticle aqueous dispersion as the seed emulsion, dilute it by 1 time, add 3g N-isopropylacrylamide, 0.3g methylenebisacrylamide, and pass nitrogen gas to remove oxygen for 1 hour, then heat up At 60°C, add 0.2 g of ammonium persulfate, react for 6 hours, and stir at a speed of 400 rpm to obtain a composite particle emulsion with a temperature-sensitive polymer as the shell and silica particles as the core.

[0032] After diluting the composite particle emulsion obtained above by 8 times, add 1g of acrylic acid, 0.3g of methylenebisacrylamide, and pass nitrogen gas to remove ...

Embodiment 2

[0037] Mix 3g TEOS, 8g deionized water, 2g ammonia water and 100g ethanol evenly, and stir at room temperature for 48 hours at a stirring speed of 200 rpm. Subsequently, 0.5 g of 3-trimethoxysilylpropyl methacrylate was added, and stirring was continued for 48 hours at a stirring speed of 200 rpm to form a modified silica nanoparticle aqueous dispersion.

[0038] Use the above-mentioned modified silicon dioxide nanoparticle aqueous dispersion as the seed emulsion, dilute it twice, add 2g of N-isopropylacrylamide, 0.4g of methylenebisacrylamide, and pass nitrogen gas to remove oxygen for 1 hour. Raise the temperature to 40°C, add 0.2 g of potassium persulfate, react for 8 hours, and stir at a speed of 300 rpm to obtain a composite particle emulsion with a temperature-sensitive polymer as the shell and silica particles as the core.

[0039] After diluting the composite particle emulsion obtained above by 5 times, add 1.6g of methacrylic acid, 0.5g of methylenebisacrylamide, pass...

Embodiment 3

[0044] Mix 5g TEOS, 10g deionized water, 2g ammonia water and 60g ethanol evenly, and stir at room temperature for 48 hours at a stirring speed of 400 rpm. Subsequently, 0.6 g of 3-trimethoxysilylpropyl methacrylate was added, and stirring was continued for 48 hours at a stirring speed of 400 rpm to form a modified silica nanoparticle aqueous dispersion.

[0045] The above-mentioned modified silica nanoparticle aqueous dispersion was used as the seed emulsion, diluted 4 times, added 5g of N-tert-butylacrylamide, 0.5g of methylenebisacrylamide, and deoxygenated by nitrogen gas for 1 hour, Raise the temperature to 80°C, add 0.3 g of benzoyl peroxide, react for 4 hours, and stir at a speed of 300 rpm to obtain a composite particle emulsion with a temperature-sensitive polymer as the shell and silicon dioxide particles as the core.

[0046] After diluting the composite particle emulsion obtained above by 8 times, add 3 g of tert-butyl acrylate and 0.3 g of methylenebisacrylamide, ...

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Abstract

The invention relates to a temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof. The microcapsule comprises two polymers sensitive to temperature and pH, and an interpenetrating network structure is formed between the two polymers. Preparation includes the following steps: (1) uniformly blending tetraethyl orthosilicate, aqueous ammonia, water and absolute ethyl alcohol, and then adding surface modifier; (2) adding temperature-sensitive monomer and crosslinking agent into the modified dispersion, and adding initiator for reaction; (3) after diluting the emulsion by five to fifteen times, adding pH-sensitive monomer and crosslinking agent, and adding initiator for reaction; and (4) dispersing the white emulsion of core-shell composite particles with shells formed into a interpenetrating polymer network structure into hydrofluoric acid, and carrying out centrifugal separation or dialysis purification. The microcapsule can respectively respond tothe stimulation of temperature and pH, and moreover, the two types of stimuli responsiveness are independent from each other, and therefore have little interference on each other. The preparation method is simple, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of polymer microcapsules and its preparation, in particular to an intelligent polymer microcapsule with double stimulus response to temperature and pH value and its preparation. Background technique [0002] For the drug loading and release system, researchers at home and abroad have been looking for a drug delivery system (Drug Delivery System, DDS) that can directly deliver the drug to the lesion in the human body without causing toxic side effects to other parts of the human body. ). Since Tanaka et al. discovered in 1978 that the smaller the size of the hydrogel, the shorter the time to reach swelling or shrinking equilibrium, it can respond to environmental factors such as temperature and pH, and the particle size is in the micron or nanoscale. Smart microgels have become a hot research favorite. For example, in 1986, Pelton in Canada first reported the development of smart microgels, which started the research ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F220/06C08F220/18C08F222/38C08F292/00C08F285/00B01J13/14A61K47/32A61K9/50
Inventor 邢志敏查刘生
Owner DONGHUA UNIV
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