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Photo-responsive controlled-release nano-pesticide preparation and preparation method and application thereof

A light-responsive, nano-pesticide technology, applied in the direction of botanical equipment and methods, applications, herbicides and algicides, etc., can solve the problem that the quantity of drugs does not meet the requirements, the time for drug efficacy is not enough, and the adverse effects on humans and the environment To achieve good anti-dilution stability, improve the efficiency of drug action, and reduce the number of application times

Inactive Publication Date: 2017-05-31
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Widespread use of pesticides in agriculture contributes to global food security, but also has adverse effects on people and the environment
There are many problems in the use of up to 90% of traditional pesticides: they never reach the target, the time to reach the target is not enough to exert their drug effect, or the amount of drugs reaching the target does not meet the requirements, so it is difficult to produce the expected biological effect
However, the photoresponsive nanoparticles reported in the literature so far are mainly used as carriers for controlled release of drugs, and the design for controlled release of pesticides has not been reported yet.

Method used

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  • Photo-responsive controlled-release nano-pesticide preparation and preparation method and application thereof
  • Photo-responsive controlled-release nano-pesticide preparation and preparation method and application thereof
  • Photo-responsive controlled-release nano-pesticide preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Preparation of o-nitrobenzyl succinic acid monoester:

[0044] Weighing a molar ratio of 1:2 o-nitrobenzyl alcohol and succinic anhydride dissolved in chloroform, adding catalyst 4-dimethylaminopyridine (DMAP) in an amount 0.2 times the amount of raw material, under nitrogen protection environment, reflux After reacting for 24 hours, after stopping the reaction, part of the chloroform was distilled off under reduced pressure, and the remaining reaction solution was washed three times with a 10% (v / v) HCl solution by volume percentage, then extracted and washed with a saturated sodium bicarbonate solution, and washed with a volume percentage concentration of The pH of the aqueous phase was adjusted to 5 for a 10% (v / v) HCl solution, and a large amount of white precipitate formed. Collect the white precipitate and dry it under vacuum at 40°C to obtain o-nitrobenzyl succinic acid monoester (NBS).

[0045] The vacuum drying process parameters are: vacuum degree<133Pa, ...

Embodiment 2

[0054] (1) Preparation of o-nitrobenzyl succinic acid monoester:

[0055] With embodiment 1.

[0056] (2) Preparation of o-nitrobenzyl succinic acid monoester DMF solution activated by NHS and EDC HCl:

[0057] Dissolve the o-nitrobenzyl succinic acid monoester in DMF, and stir evenly at room temperature to prepare a 20% by weight o-nitrobenzyl succinic acid monoester DMF solution. The solution was cooled to 0-5°C, according to o-nitrobenzyl succinic acid monoester: N-hydroxysuccinimide (NHS): 1-(3-dimethylaminopropyl)-3-ethylcarbodiethylene Amine hydrochloride (EDC·HCl) is 1:1.1:1.1 in molar ratio, add NHS and EDC·HCl in turn, react at room temperature for 24 hours, and filter the reaction solution to obtain o-nitrobenzyl succinic acid activated by NHS and EDC·HCl Monoester DMF solution.

[0058] (3) Preparation of photoresponsive carboxymethyl chitosan

[0059] Take a carboxymethyl chitosan aqueous solution with a carboxymethyl substitution degree of 1.2 and a weight per...

Embodiment 3

[0062] (1) Preparation of o-nitrobenzyl succinic acid monoester:

[0063] With embodiment 1.

[0064] (2) Preparation of o-nitrobenzyl succinic acid monoester DMF solution activated by NHS and EDC HCl:

[0065] Dissolve the o-nitrobenzyl succinic acid monoester in DMF, and stir evenly at room temperature to prepare a 15% o-nitrobenzyl succinic acid monoester DMF solution. The solution was cooled to 0-5°C, according to o-nitrobenzyl succinic acid monoester: N-hydroxysuccinimide (NHS): 1-(3-dimethylaminopropyl)-3-ethylcarbodiethylene Amine hydrochloride (EDC·HCl) is 1:1.1:1.1 in molar ratio, add NHS and EDC·HCl in turn, react at room temperature for 24 hours, and filter the reaction solution to obtain o-nitrobenzyl succinic acid activated by NHS and EDC·HCl Monoester DMF solution.

[0066] (3) Preparation of photoresponsive carboxymethyl chitosan

[0067] Take a carboxymethyl chitosan aqueous solution with a carboxymethyl substitution degree of 1.6 and a concentration of 5.0...

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Abstract

The invention relates to photo-responsive controlled-release nano-pesticide preparation and a preparation method and application thereof. A controlled-release effective constituent of the preparation is amphiphilic carboxymethyl chitosan derivative which is obtained through reaction between o-nitro benzyl hemisuccinate and carboxylmethyl chitosan. The preparation is prepared by the following steps: taking water solution of the carboxymethyl chitosan, adding organic solution of the o-nitro benzyl hemisuccinate activated by NHS and EDC.HCl according to the molar ration of sugar moiety of the carboxymethyl chitosan to the o-nitro benzyl hemisuccinate as 1 to (0.01 to 1), reacting for 6h in room temperature, then dialyzing and freeze drying to obtain photo-responsive carboxymethyl chitosan derivative, dispersing the derivative and pesticide into water at the same time and performing ultrasound at intervals to obtain photo-responsive controlled-release pesticide nanoparticle. The photo-responsive controlled-release nano-pesticide preparation can be selectively sprayed on the surfaces of or in target plants and pests under the condition free of illumination. Once the photo-responsive controlled-release nano-pesticide preparation is applied to the surfaces of or in the target plants and the pests, the photo-responsive controlled-release nano-pesticide preparation can respond external sunshine stimulation to release pesticide at any time.

Description

technical field [0001] The invention relates to a controlled-release nano-pesticide preparation, in particular to a light-responsive controlled-release nano-pesticide preparation and its preparation method and application. Background technique [0002] The widespread use of pesticides in agriculture contributes to global food security, but also has adverse effects on humans and the environment. There are many problems in the use of up to 90% of traditional pesticides: they never reach the target point, the time to reach the target point is not enough to exert the drug effect, or the amount of drug reaching the target point does not meet the requirements, so it is difficult to produce the expected biological effect. [0003] The reason for this phenomenon is the non-specific and repeated application of these pesticides. This not only increases the cost of pesticide use, but also causes environmental pollution. Because of the high cost of synthesizing new compounds to replac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N25/04A01P13/00A01P7/00A01P21/00C08B37/08
CPCA01N25/10A01N25/04C08B37/003
Inventor 殷以华叶昭郭晶晶丁凯凯张玲
Owner WUHAN UNIV OF TECH
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