The invention relates to the technical field of oral medical treatment, in particular to a cleaning spray bottle for an oral operation. The cleaning spray bottle comprises a sprayer, water outlets areuniformly formed in the top of the sprayer, hairbrush teeth are vertically and fixedly connected at the tops of the water outlets, a threaded female column is fixedly connected on the right side of the sprayer, a first connecting pipe is arranged on one side, close to the sprayer, of the inner cavity of the threaded female column, a mechanical rod is arranged on the right side of the threaded female column, a threaded male column is embedded into one side, close to the threaded female column, of an inner cavity of the mechanical rod, a second connecting pipe is embedded into one side, close to the threaded female column, of the inner cavity of the threaded male column, a connecting rod is fixedly connected on the right side of the threaded male column, and a vibration motor is fixedly connected on the right side of the connecting rod. According to the cleaning spray bottle, two functions of oral cleaning and spraying are integrated, an oral cavity is more conveniently, rapidly and thoroughly cleaned, the cleaning spray bottle is reasonable in structure and simple to operate, and great convenience is provided for a user.