Traditional Chinese medicine composition for treating AIDS and preparation method thereof

Abstract

The invention aims to provide a traditional Chinese medicine composition for treating AIDS (Acquired Immune Deficiency Syndrome). The pharmaceutical composition is prepared by processing the following raw material medicines: astragalus membranaceus, codonopsis pilosula, radix scrophulariae, bran-fried rhizoma atractylodis macrocephalae, Chinese yam, pericarpium citri reticulatae, angelica sinensis, salvia miltiorrhiza, ligusticum wallichii, radix cyathulae, raw liquorice, scorched hawthorn fruit, scorched medicated leaven and scorched malt. Pharmacodynamic tests prove that the medicine can enhance the immune function of AIDS patients, delay the decline speed of CD4 + T cells, activate latent HIV viruses and reservoirs, slow down the disease progress, protect the liver function, relieve clinical symptoms and the like.

Description

Technical Field

[0001] The invention belongs to the field of medicine, and specifically relates to a traditional Chinese medicine composition for treating AIDS and a preparation method thereof. Background Art

[0003] AIDS is caused by the combination of "epidemic toxins" and dampness, heat and other evils invading the human body, damaging the body's vitality and causing the deficiency of positive energy. The main manifestations are deficiency of qi, blood, yin and yang in the spleen and kidney. Among them, since the spleen is the foundation of the acquired constitution and the source of qi and blood, if the spleen is deficient, qi and blood cannot be transformed, and the innate cannot be nourished, resulting in deficiency of qi, blood, yin and yang in the whole body. Therefore, strengthening the spleen and kidney is one of the basic methods for treating AIDS. Our previous research results show that the Yiqi Jianpi recipe can enhance the immune function of HIV-specific T cells. From the perspective of traditional Chinese medicine, the immune function of T cells is the body's positive energy. The Yiqi Jianpi recipe can enhance the immune function of HIV-specific T cells, which means that it enhances the body's positive energy and plays a "supporting the positive energy". HAART treatment kills HIV viruses, which is "eliminating evil" from the perspective of traditional Chinese medicine. Therefore, the Yiqi Jianpi recipe combined with HAART antiviral treatment conforms to the basic principle of "supporting the positive energy and eliminating evil" in the treatment of infectious diseases in traditional Chinese medicine. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for treating AIDS.

[0005] The pharmaceutical composition of the present invention is processed from the following raw materials:

[0006] Astragalus 15-60g, Codonopsis pilosula 7.5-30g, Scrophularia 7.5-30g, Atractylodes macrocephala 5-20g, Chinese yam 7.5-30g,

[0007] Tangerine peel 4.5-18g, Chinese angelica 6-24g, Salvia miltiorrhiza 7.5-30g, Chuanxiong 4.5-18g, Cyathula officinalis 5-20g,

[0008] 4.5-18g raw licorice, 5-20g scorched hawthorn, 5-20g scorched Shenqu, 5-20g scorched malt.

[0009] Preferably, the pharmaceutical composition of the present invention is processed from the following raw materials:

[0010] Astragalus 30g, Codonopsis pilosula 15g, Scrophularia 15g, Atractylodes macrocephala 10g, Chinese yam 15g, Tangerine peel 9g,

[0011] Angelica 12g, Salvia miltiorrhiza 15g, Chuanxiong 9g, Cyathula 10g, Raw Licorice 9g, Scorched Hawthorn 10g,

[0012] 10g of roasted Shenqu and 10g of roasted malt.

[0013] Another object of the present invention is to provide a method for preparing the pharmaceutical composition.

[0014] The preparation method of the present invention comprises the following steps:

[0015] ① Preparation and cleaning of medicinal materials: Take 30g of Astragalus, 15g of Codonopsis, 15g of Scrophularia, 10g of Atractylodes macrocephala with bran, 15g of Dioscorea, 9g of Tangerine peel, 12g of Angelica, 15g of Salvia miltiorrhiza, 9g of Chuanxiong, 10g of Cyathula, 9g of Raw Licorice, 10g of Charred Hawthorn, 10g of Charred Shenqu, and 10g of Charred Malt, mix the above Chinese medicinal materials and wash with clean water to remove impurities and dust on the surface;

[0016] ② Soaking herbs: Place the cleaned herbs in a decoction container, add enough cold water to cover the herbs by about 3-5 cm (usually 800-1000 ml of water for every 100 g of herbs), and soak for 30 minutes to allow the herbs to fully absorb water, which is conducive to the release of active ingredients;

[0017] ③ First decoction: After soaking, boil over medium heat, then switch to low heat and continue to decoct for 10-15 minutes. Keep the decoction at a low boil and avoid over-boiling over high heat. After decoction, filter out the liquid with gauze or a fine mesh, and squeeze the residue to extract the liquid.

[0018] ④ Second decoction: put the residue back into the decoction container, add water again (the amount is 2 / 3 of the first time, about 500-700ml of water for every 100g of medicinal materials), boil again over medium heat, then simmer for 5-10 minutes over low heat. After decoction is completed, filter out the liquid with gauze or a fine mesh, and squeeze out the residue;

[0019] ⑤ Combine the medicinal liquids: Combine the medicinal liquids decocted twice and mix them thoroughly to obtain the water decoction of the prescription.

[0020] The pharmaceutical active substance of the present invention may account for 0.1-99.9% by weight in the preparation, and the rest is a pharmaceutically acceptable carrier. The pharmaceutical preparation of the present invention is in the form of a unit dose, which refers to the unit of the preparation, such as each tablet of a tablet, each capsule of a capsule, each bottle of an oral solution, each bag of granules, etc.

[0021] The pharmaceutical preparation of the present invention can be any pharmaceutically acceptable dosage form, including oral, external, injection and other dosage forms, and these dosage forms include: tablets, sugar-coated tablets, film-coated tablets, enteric-coated tablets, capsules, hard capsules, soft capsules, oral liquids, lozenges, granules, electuary, pills, powders, pastes, pills, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, drops, and patches. The preparation of the present invention is preferably an oral dosage form, such as capsules, tablets, oral liquids, granules, pills, powders, pills, pastes, etc.

[0022] The pharmaceutical preparation of the present invention, its preparation for oral administration may contain commonly used excipients, such as binders, fillers, diluents, tableting agents, lubricants, disintegrants, colorants, flavoring agents and wetting agents, and the tablets may be coated if necessary.

[0023] Suitable fillers include cellulose, mannitol, lactose and other similar fillers. Suitable disintegrants include starch, polyvinyl pyrrolidone and starch derivatives, such as sodium starch glycolate. Suitable lubricants include, for example, magnesium stearate. Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulfate.

[0024] Solid oral compositions can be prepared by conventional methods of mixing, filling, tableting, etc. Repeated mixing can be used to distribute the active substance throughout those compositions using large amounts of fillers.

[0025] Oral liquid preparations may be in the form of aqueous or oily suspensions, solutions, emulsions, syrups or elixirs, or may be a dry product that can be reconstituted with water or other suitable carriers before use. Such liquid preparations may contain conventional additives, such as suspending agents, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminum stearate gel or hydrogenated edible fats, emulsifiers, for example lecithin, sorbitan monooleate or gum arabic; non-aqueous carriers (which may include edible oils), for example almond oil, fractionated coconut oil, oily esters such as glycerol esters, propylene glycol or ethanol; preservatives, for example methylparaben or propylparaben or sorbic acid, and, if desired, conventional flavoring or coloring agents.

[0026] For injection, a liquid unit dosage form is prepared containing the active substance of the invention and a sterile carrier. Depending on the carrier and concentration, the compound can be suspended or dissolved. Solutions are usually prepared by dissolving the active substance in a carrier, filtering and sterilizing it before filling it into a suitable vial or ampoule, and then sealing it. Excipients such as a local anesthetic, preservatives and buffers can also be dissolved in this carrier. In order to improve its stability, the composition can be frozen after filling into the vial and the water removed under vacuum.

[0027] The pharmaceutical preparation of the present invention can selectively add a suitable pharmaceutically acceptable carrier when preparing the medicament, and the pharmaceutically acceptable carrier is selected from the group consisting of mannitol, sorbitol, sodium pyrosulfite, sodium bisulfite, sodium thiosulfate, cysteine ​​hydrochloride, thioglycolic acid, methionine, vitamin C, disodium EDTA, sodium calcium EDTA, carbonates, acetates, phosphates of monovalent alkali metals or their aqueous solutions, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acids, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and its derivatives, alginate, gelatin, polyvinyl pyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactants, polyethylene glycol, cyclodextrin, β-cyclodextrin, phospholipid materials, kaolin, talc, calcium stearate, magnesium stearate, etc.

[0028] Compared with existing drugs, the pharmaceutical composition of the present invention has the following beneficial effects:

[0029] 1. The Qi-invigorating and spleen-strengthening formula can slow down the decline of CD4+T cells in HIV / AIDS patients, slow down the progression of AIDS, protect liver function, and relieve clinical symptoms;

[0030] 2. The Yiqi Jianpi recipe can enhance the immune function of HIV-specific T cells in AIDS patients;

[0031] 3. The Yiqi Jianpi recipe can activate the dormant CD4+T cells in AIDS patients and significantly increase the ratio of activated CD4+T cells (HLA-DR+CD4+T);

[0032] 4. The Qi-invigorating and spleen-strengthening formula can activate latent HIV virus reservoirs in vitro, which is beneficial for clearing latent HIV viruses and thus achieving the effect of treating AIDS.

[0033] In the drug formula of the present invention, astragalus is sweet, warm and invigorating qi as the main drug, which can invigorate vital energy, strengthen spleen and stomach, and replenish various deficiencies. Codonopsis, Atractylodes macrocephala, Licorice, Chinese yam and Chinese angelica are assistant drugs for invigorating qi and strengthening spleen, and tangerine peel is aromatic and invigorating spleen, so that the sweet, warm and slow invigorating qi and strengthening spleen are combined with the functions of regulating qi and strengthening spleen, which is the adjuvant drug.

[0034] Modern pharmacological research believes that Atractylodes macrocephala, Angelica sinensis, and Astragalus membranaceus can enhance immune function by replenishing qi and blood. Astragalus membranaceus can promote the proliferation of CD4+T lymphocytes and enhance their function, improve the CD4+T / CD8+T ratio, and fight against CD4+T exhaustion. Pharmacological studies at home and abroad have consistently shown that Codonopsis pilosula and Astragalus membranaceus can increase the number of white blood cells, and Chinese yam can enhance the phagocytic function of neutrophils. The combination of these medicines can achieve the effect of replenishing qi, strengthening the spleen and strengthening the body.

[0035] The pharmaceutical composition of the present invention can significantly improve the clinical symptoms of HIV / AIDS patients, improve the quality of life, delay the decline of CD4+T cells, and alleviate the toxic and side effects of HAART, and has certain advantages in protecting liver function. After the preparation of the medicine of the present invention, it is placed in a cool, dry, and ventilated place and kept by a special person. It is ensured that the drugs taken in the test of this project are from the same batch of drugs to avoid differences between drug batches.

[0036] Another object of the present invention is to provide use of the pharmaceutical composition of the present invention in preparing a drug for treating AIDS.

[0037] The pharmaceutical composition of the present invention is used in preparing medicines for protecting liver function, enhancing immune function, delaying the decline rate of CD4+T cells, and activating latent HIV viruses and reservoirs.

[0038] Another object of the present invention is to provide the use of the pharmaceutical composition of the present invention in combination with HAART drugs in the preparation of drugs for treating AIDS.

[0039] Another object of the present invention is to provide the use of the pharmaceutical composition of the present invention in combination with HAART drugs in the preparation of drugs for protecting liver function, enhancing immune function, delaying the decline rate of CD4+T cells, and activating latent HIV viruses and reservoirs.

[0040] The existing experimental results show that the Yiqi Jianpi Formula (YQJPF) alone is also effective in the treatment of AIDS ( Figure 7 , Figure 8 , Fig. 9 ), and the effect is more significant when combined with HAART drugs.

[0041] Definition of terms

[0042] The terms used in the description of the present invention herein are only for describing specific embodiments and are not intended to limit the present invention. The nomenclature used herein and the laboratory operations in the organic chemistry, medicinal chemistry, and biology described herein are well known and commonly used in the art. Unless otherwise mentioned, all technical and scientific terms used herein have the same meaning as those generally understood by those skilled in the art to which this art belongs.

[0043] As used in the description of the embodiments of the present invention and the appended claims, the singular forms "a", "an", "the", and "its" are intended to refer to both the singular and the plural, unless the context clearly dictates otherwise. For example, a compound includes one or more than one compound.

[0044] As used herein, "and / or" refers to and includes any and all possible combinations of one or more of the associated listed items.

[0045] As used herein, the term "disease" or "disorder" refers to any change in the state of the body or some organ that interrupts or interferes with the performance of its functions and / or causes symptoms.

[0046] As used herein, the term "treatment" is intended to alleviate or eliminate the disease state or condition being targeted. If a subject receives a therapeutic amount of a compound or a pharmaceutically acceptable salt, isomer, polymorph, solvate, isotope-labeled compound, metabolite or prodrug thereof, or a pharmaceutical composition thereof according to the methods described herein, and one or more signs and symptoms of the subject show an observable and / or detectable decrease or improvement, then the subject is successfully "treated". It should also be understood that the treatment of the disease state or condition includes not only complete treatment, but also failure to achieve complete treatment, but achieving some biological or medically relevant results.

[0047] As used herein, the term "subject" may refer to a patient or other animal receiving the composition of the present invention to treat, prevent, alleviate and / or alleviate the disease or condition described in the present invention, and in the present invention, particularly refers to humans and mammals.

[0048] Further explanation of the terms or English words that appear in the manual:

[0049] HAART: highly active combination antiretroviral therapy. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 , Yiqi Jianpi prescription combined with HAART treatment enhanced HIV-specific T cell immune response (*P<0.05);

[0051] Figure 2 , Yiqi Jianpi prescription combined with HAART in the treatment of HIV-specific T cell immune response at different treatment time points

[0052] Condition;

[0053] Figure 3 2. Qi-invigorating and spleen-strengthening prescription combined with HAART treatment group;

[0054] Figure 4 , HAART alone treatment group;

[0055] Figure 5 , the ratio of activated CD4+T cells between the two groups;

[0056] Figure 6 , dynamic changes of activated CD4+T cells;

[0057] Figure 7 , dynamic changes of total HIV DNA at each time point;

[0058] Figure 8 , three Total HIV DNA content at each time point in each group;

[0059] Fig. 9 , three Total HIV DNA content at different treatment time points in the groups;

[0060] Fig. 9 A: Total HIV DNA content at each time point in the HAART group alone

[0061] Fig. 9 B: Total HIV DNA content at different treatment time points in the YQJPF group alone

[0062] Fig. 9 C: Total HIV DNA content at different time points in the group treated with the Qi-invigorating and spleen-strengthening prescription combined with HAART. DETAILED DESCRIPTION

[0063] The present invention is further illustrated by the following examples.

[0064] The product and preparation method of the present invention are further described below in conjunction with specific examples, but the present invention is not limited to the following examples. The methods are conventional methods unless otherwise specified. The raw materials can be obtained from public commercial channels unless otherwise specified.

[0065] Example 1. Pharmaceutical composition of the present invention

[0066] Astragalus 30g, Codonopsis pilosula 15g, Scrophularia 15g, Atractylodes macrocephala 10g, Chinese yam 15g, Tangerine peel 9g,

[0067] Angelica 12g, Salvia miltiorrhiza 15g, Chuanxiong 9g, Cyathula 10g, Licorice root 9g, Scorched hawthorn 10g,

[0068] 10g of roasted Shenqu and 10g of roasted malt.

[0069] Example 2: Pharmaceutical composition of the present invention

[0070] Astragalus 15g, Codonopsis pilosula 7.5g, Scrophularia 7.5g, Atractylodes macrocephala 5g, Chinese yam 7.5g,

[0071] Tangerine peel 4.5g, Chinese angelica 6g, Salvia miltiorrhiza 7.5g, Chuanxiong 4.5g, Cyathula officinalis 5g,

[0072] 4.5g raw licorice, 5g scorched hawthorn, 5g scorched Shenqu, and 5g scorched malt.

[0073] Example 3, pharmaceutical composition of the present invention

[0074] Astragalus 60g, Codonopsis pilosula 30g, Scrophularia 30g, Atractylodes macrocephala 20g, Chinese yam 30g,

[0075] Tangerine peel 18g, Chinese angelica 24g, Salvia miltiorrhiza 30g, Chuanxiong 18g, Cyathula officinalis 20g,

[0076] 18g raw licorice, 20g scorched hawthorn, 20g scorched Shenqu, and 20g scorched malt.

[0077] Example 4, drug efficacy experiment

[0078] Inclusion criteria for the study subjects: HIV / AIDS patients aged 18 to 50 years (diagnostic criteria refer to the AIDS Diagnosis and Treatment Guidelines 2011);

[0079] Experimental groups and treatments

[0080] ① HAART alone treatment group (40 people): tenovudine (TDF, 300 mg per tablet, Aspen Port Elizabeth (Pty) Ltd, batch number H20130589) 300 mg each time, once a day; lamivudine (3TC, 300 mg per tablet, Shandong Weifang Pharmaceutical Factory Co., Ltd., batch number H20133056) 300 mg each time, once a day; efavirenz (EFV, 600 mg per tablet, Zhejiang Huahai Pharmaceutical Co., Ltd., batch number H20133265) 600 mg each time, once a day.

[0081] ②Qi-invigorating and spleen-strengthening prescription + HAART treatment group (40 people): Qi-invigorating and spleen-strengthening prescription (Example 1) was given on the basis of HAART treatment, and the patients were re-examined once a month. The Chinese medicine was uniformly decocted by the decoction room of our hospital, and each dose of medicine was decocted into 2 bags (vacuum packed), each bag was 150 ml, and 1 bag was taken in the morning and evening every day. 1 dose per day, 1 hour apart from the HAART drug, taken with hot water at about 80-100°C, and the medication time was 6 months. Every 3 months was 1 course of treatment, for a total of 2 courses of treatment.

[0082] Yiqi Jianpi Recipe: It can significantly improve the clinical symptoms of HIV / AIDS patients, improve the quality of life, delay the decline of CD4+T cells, and reduce the toxic side effects of HAART. It has certain advantages in protecting liver function. Yiqi Jianpi Recipe is made into granules by Beijing Kangrentang Pharmaceutical Co., Ltd. in accordance with the industry quality control system and quality standards of Chinese medicine formula granules. After the medicine is made, it is placed in a cool, dry and ventilated place and kept by a dedicated person. Ensure that the drugs taken in the experiment of this project are from the same batch of drugs to avoid differences between drug batches.

[0083] (1) Enhance HIV-specific T cell immune function in HIV / AIDS patients

[0084] In long-term clinical practice, it was found that HAART combined with "Qi-invigorating and spleen-strengthening prescriptions" can significantly improve clinical symptoms and signs, delay the decline of CD4+T cells, and improve the quality of life. And it has certain advantages in protecting liver function. Qi-invigorating and spleen-strengthening prescriptions combined with HAART can increase the secretion of IFN-γ by T cells and enhance the HIV-specific T cell immune function of HIV / AIDS patients. ( Figure 1 , Figure 2 ).

[0085] (2) Research on activation of CD4+T cells

[0086] When we studied the effect of Yiqi Jianpi prescription on T cell immune function, we found that Yiqi Jianpi prescription combined with HAART treatment can increase the ratio of activated CD4+T cells in peripheral blood. The average ratio of HLA-DR+CD4+T cells in CD4+T cells in the Yiqi Jianpi prescription combined with HAART treatment group was about 21%, while the average ratio of HLA-DR+CD4+T cells in CD4+T cells in the HAART treatment group was about 6% ( Figure 3 , Figure 4 The Qi-invigorating and spleen-strengthening prescription combined with HAART treatment group was significantly higher than the HAART treatment group alone ( Figure 5 ), and increases with the duration of treatment ( Figure 6 ).

[0087] (3) Research on clearing latent HIV reservoirs (total amount of HIV DNA)

[0088] We previously studied the latent HIV reservoirs in the three groups of patients after treatment: the Qi-invigorating and spleen-strengthening prescription group alone, the HAART group alone, and the Qi-invigorating and spleen-strengthening prescription combined with HAART. We found that the latent HIV reservoirs (HIV DNA) in the Qi-invigorating and spleen-strengthening prescription combined with HAART group were significantly lower than those in the HAART group and the Qi-invigorating and spleen-strengthening prescription group after 48 weeks of treatment ( Figure 7 , Figure 8 and Fig. 9 The results of this experiment show that the Qi-invigorating and spleen-strengthening prescription combined with HAART treatment can significantly reduce the latent HIV virus reservoir.

[0089] Example 5. Therapeutic effect of the present invention

[0090] The present invention is improved on the basis of the original formula.

[0091]

[0092] In the process of using the original formula, we found that most AIDS patients have anemia symptoms. At the same time, according to the clinical efficacy of the original formula and patient feedback, the present invention has been improved on the basis of the original formula. Details are as follows: Eight new medicinal materials are added, 1. Angelica: promote blood circulation, promote blood circulation, and improve anemia caused by AIDS; 2. Chuanxiong: promote qi and blood circulation, promote circulation, help alleviate the qi deficiency and blood stasis caused by the disease, thereby improving the overall vitality and energy level of the patient; 3. Scrophularia: nourish yin and reduce fire, can help alleviate the symptoms of yin deficiency caused by long-term patients, enhance the resistance of the patient's immune system, thereby reducing the risk of inflammation and infection; 4. Tangerine peel: regulate qi and strengthen the spleen, help eliminate gastrointestinal dysfunction caused by long-term medication, improve nutrient absorption, and enhance physical fitness; 5. Sichuan Achyranthes: has the effect of guiding the drug downward, promoting blood circulation, helping to improve the limb fatigue and discomfort caused by long-term illness, so that patients can maintain good mobility; 6. Charred hawthorn, 7. Charred Shenqu, 8. Charred malt: these three medicines can strengthen the spleen and appetite, which is beneficial to alleviate the gastrointestinal adverse reactions of antiviral drugs. The two Chinese medicines, Ligustrum lucidum for nourishing yin and kidney and Poria cocos for promoting diuresis and removing dampness, have been removed. The eight newly added medicinal materials can improve the immunity of AIDS patients and reduce the occurrence of complications by improving immune function, promoting blood circulation, strengthening spleen and stomach function and digestion and absorption. The adjusted invention has more prominent effects of invigorating qi and strengthening spleen, promoting qi and activating blood circulation, and has better clinical efficacy.

[0093] Example 6: Comparison of clinical efficacy between the present invention and the original formulation

[0094] 1. The clinical efficacy of the drug is significantly enhanced: ① The anemia symptoms of AIDS patients are significantly improved. In the process of using the original formula drug clinically, it is found that most AIDS patients have anemia symptoms. The present invention adds angelica to promote blood circulation and blood supplementation, and adds Chuanxiong to promote qi and blood circulation, which significantly improves the anemia symptoms of AIDS patients; ② The immune function of AIDS patients is further enhanced. The present invention adds tangerine peel to regulate qi and strengthen the spleen on the basis of the original formula to invigorate qi and strengthen the spleen, enhances the spleen and stomach function and digestion and absorption of patients, and provides the necessary material basis for enhancing the immune function of patients. At the same time, adding angelica to replenish blood improves the anemia symptoms of patients, and Chuanxiong promotes blood circulation of patients, thereby further enhancing the overall resistance and immune function of AIDS patients; ③ The fatigue and weakness of AIDS patients are significantly improved. Due to the consumption of long-term chronic diseases, AIDS patients are prone to fatigue and weakness. The present invention adds Chuanxiong to guide the downward movement of the drug, promote the meridians and activate the collaterals, help improve the weakness and discomfort of the limbs caused by long-term illness, enable patients to maintain good mobility, and significantly improve the fatigue and weakness of AIDS patients. Clinical symptoms.

[0095] 2. The side effects such as diarrhea caused by the original formula are significantly improved. Some patients with the original formula have diarrhea symptoms during clinical use. The present invention adjusts the medicine, adds three herbs, namely, scorched hawthorn, scorched Shenqu and scorched malt, to strengthen the spleen and stimulate appetite, effectively relieve gastrointestinal adverse reactions, and significantly improve diarrhea symptoms.

[0096] The drugs of the present invention are compatible with each other, and while reducing side effects, produce very good synergistic therapeutic effects.

Claims

1. A Chinese medicine composition for treating AIDS, characterized in that: It is made from the following raw materials: 15-60g of Astragalus, 7.5-30g of Codonopsis, 7.5-30g of Scrophularia, 5-20g of Atractylodes macrocephala, 7.5-30g of Dioscorea batatas, 4.5-18g of Citrus reticulata, 6-24g of Angelica sinensis, 7.5-30g of Salvia miltiorrhiza, 4.5-18g of Chuanxiong, 5-20g of Cyathula, 4.5-18g of Raw Licorice, 5-20g of Charred Hawthorn, 5-20g of Charred Shenqu, and 5-20g of Charred Malt.

2. The Chinese medicine composition according to claim 1, characterized in that: Made from the following raw materials: 30g Astragalus, 15g Codonopsis, 15g Scrophularia, 10g Atractylodes macrocephala, 15g Chinese yam, 9g Tangerine peel, Angelica 12g, Salvia miltiorrhiza 15g, Ligusticum chuanxiong 9g, Cyathula officinalis 10g, raw licorice 9g, charred hawthorn 10g, charred Shenqu 10g, charred malt 10g.

3. A pharmaceutical preparation comprising the Chinese medicine composition according to claim 1.

4. The pharmaceutical preparation according to claim 3, characterized in that It can be in any pharmaceutically acceptable dosage form, including: Oral, external, injection dosage forms, tablets, sugar-coated tablets, film-coated tablets, enteric-coated tablets, capsules, hard capsules, soft capsules, oral liquids, lozenges, granules, granules, pills, powders, pastes, pills, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, drops, patches.

5. The method for preparing the Chinese medicine composition according to claim 1, comprising the following steps: ① Preparation and cleaning of medicinal materials: Take 30g of Astragalus, 15g of Codonopsis, 15g of Scrophularia, 10g of Atractylodes macrocephala with bran, 15g of Dioscorea, 9g of Tangerine peel, 12g of Angelica, 15g of Salvia miltiorrhiza, 9g of Chuanxiong, 10g of Cyathula, 9g of Raw Licorice, 10g of Charred Hawthorn, 10g of Charred Shenqu, and 10g of Charred Malt, mix the above Chinese medicinal materials and wash with clean water to remove impurities and dust on the surface; ② Soaking of medicinal materials: Place the cleaned medicinal materials in a decoction container and add sufficient cold water. For every 100g of medicinal materials, add 800-1000ml of water. Soak for 30 minutes to allow the medicinal materials to fully absorb water. It is conducive to the release of active ingredients; ③First decoction: Boil over medium heat after soaking, then switch to low heat and continue decocting for 10-15 minutes. When decocting, keep the medicine in a slightly boiling state and avoid over-boiling over high heat. After decocting, filter out the liquid with gauze or a fine mesh, and squeeze the residue to extract the liquid. ④ Second decoction: Put the residue back into the decoction container, add water again, the dosage is about 500-700ml per 100g of medicinal materials, boil again on medium heat, then simmer for 5-10 minutes on low heat. Similarly, use gauze or a fine mesh to filter out the liquid medicine and squeeze out the residue; ⑤ Combine the medicinal liquids: Combine the medicinal liquids decocted twice to obtain the extract.

6. The pharmaceutical preparation according to claim 3, characterized in that When preparing the medicament, a suitable pharmaceutically acceptable carrier can be selectively added, and the pharmaceutically acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium bisulfite, sodium thiosulfate, cysteine ​​hydrochloride, thioglycolic acid, methionine, vitamin C, disodium EDTA, sodium calcium EDTA, carbonates, acetates, phosphates or aqueous solutions of monovalent alkali metals, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acids, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and its derivatives, alginate, gelatin, polyvinyl pyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactants, polyethylene glycol, cyclodextrin, β-cyclodextrin, phospholipid materials, kaolin, talc, calcium stearate, and magnesium stearate.

7. Use of the Chinese medicine composition according to claim 1 in preparing a medicine for treating AIDS.

8. Use of the Chinese medicine composition according to claim 1 in the preparation of drugs for protecting liver function, enhancing immune function, delaying the decline rate of CD4+T cells, and activating latent HIV viruses and reservoirs.

9. Use of the Chinese medicine composition according to claim 1 in combination with HAART drugs in the preparation of drugs for treating AIDS.

10. Use of the Chinese medicine composition according to claim 1 in combination with HAART drugs in the preparation of drugs for protecting liver function, enhancing immune function, delaying the decline rate of CD4+T cells, and activating latent HIV viruses and reservoirs.

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