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Blood perfusion device having anti-coagulation function and controlled-release function and manufacturing method thereof

A blood perfusion device and perfusion device technology, applied in the field of medical devices, can solve the problems of changing the injection dosage of anticoagulants, increasing the risk of pyrogen reaction, poor convenience, etc. Effect

Active Publication Date: 2014-11-19
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be clearly seen from the above that the manual additional injection of anticoagulant in step ③ is less convenient, and the way of external machine injection of anticoagulant cannot change the amount of anticoagulant injection according to the actual situation of the patient, lacking individual adaptability
In addition, it is easy to introduce additional pyrogens during the above operations, increasing the risk of pyrogenic reactions

Method used

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  • Blood perfusion device having anti-coagulation function and controlled-release function and manufacturing method thereof
  • Blood perfusion device having anti-coagulation function and controlled-release function and manufacturing method thereof

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preparation example Construction

[0027] The preparation method of the above-mentioned hemoperfusion device includes providing such as figure 1 The shown perfusion device body and adsorbent, the perfusion device body has an adsorption chamber, and further includes the following steps: a) providing an anticoagulant slow-release gel with temperature-sensitive properties; b) coagulating the anticoagulant slow-release gel Filling the glue and the adsorbent into the adsorption chamber of the perfusate body; c) adding a preservation solution into the adsorption chamber; d) assembling the perfusate body.

[0028] Wherein, the preparation method of described anticoagulant slow-release gel comprises the steps:

[0029] 1) The anticoagulant, the compound containing double bonds at both ends (as a chemical crosslinking agent) and N-alkylacrylamide monomers are 5%~30%, 10%~15%, 60%~ Add 80% to sterile water for injection in turn to prepare an aqueous solution with a mass concentration of 10% to 50%. In a sealed container...

Embodiment 1

[0034] Add 50g of heparin sodium, 25g of methylenebisacrylamide, and 135g of N-isopropylacrylamide into 1L of sterile water for injection in sequence, and in a sealed container at 10°C, blow in nitrogen gas and stir for 60 minutes until the formation is complete. Dispersed homogeneous mixed aqueous solution; cool the above mixed aqueous solution to 1°C, add 1.5g of potassium persulfate after 30 minutes, inject 5mL of N,N,N',N'-tetramethylethylenediamine after 10 minutes, and protect with nitrogen Stirring was continued for 15 minutes; the stirred reaction solution was immediately poured into the forming mold, sealed and left to react at 18°C ​​for 40 hours, and then soaked in 5% heparin sodium injection aqueous solution for 8 hours. Then the reaction product was rinsed with water for injection for 12 hours to obtain an anticoagulant sustained-release gel. The slow-release gel is transparent to milky white in appearance, with a volume of 0.05cm 3 . Then, 30 g of anticoagulant...

Embodiment 2

[0037] Add 10g of heparin calcium, 5g of ethylene glycol dimethacrylate, and 27g of N-isopropylacrylamide into 200mL of sterilized water for injection in sequence, and in a sealed container at 10°C, blow nitrogen into it and stir for 60 minutes until A completely dispersed uniform mixed aqueous solution is formed; the above mixed aqueous solution is cooled to 1°C, 0.36 g of ammonium persulfate is added after 30 minutes, and 1 mL of N,N,N',N'-tetramethylethylenediamine is injected after 10 minutes. Under the protection of nitrogen, continue to stir for 15 minutes; pour the stirred reaction solution into the molding mold immediately, seal it and let it stand for reaction at 18°C ​​for 40 hours, and then soak it in the aqueous solution of heparin calcium injection with a mass fraction of 40%. Hours, and then the reaction product was rinsed with water for injection for 12 hours to obtain an anticoagulant sustained-release gel. The slow-release gel is transparent to milky white in ...

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Abstract

The invention discloses a blood perfusion device having the anti-coagulation function and the controlled-release function and a manufacturing method of the blood perfusion device. The blood perfusion device comprises a perfusion device body provided with an adsorption chamber. The adsorption chamber contains an adsorbent and anti-coagulation and controlled-release gel having the thermosensitive characteristic. The anti-coagulation and controlled-release gel contains anti-coagulation matter. The anti-coagulation and controlled-release gel can be formed by dissolving the anti-coagulation matter, a compound with the two ends containing double bonds and a N-alkyl acrylamide type monomer having the thermosensitive characteristic in water through polymerization. By the adoption of the blood perfusion device having the anti-coagulation function and the controlled-release function, the anti-coagulation function is integrated with the blood purification function, the convenience of clinical blood perfusion is improved, and the risk of introducing pyrogen additionally is avoided; the thermosensitive characteristic and the mechanical property of the anti-coagulation and controlled-release gel can be adjusted by changing reactant components, the crosslinking density, the ion strength and the water content; when coagulation happens, coagulated blood clots can squeeze the anti-coagulation and controlled-release gel, so that release of the anti-coagulation matter can be instantly accelerated by the anti-coagulation and controlled-release gel, and the effect of effectively preventing the coagulation range from expanding is achieved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a hemoperfusion device with anticoagulant slow-release function, and also to a preparation method of the hemoperfusion device. Background technique [0002] Hemoperfusion is a high-tech technology that takes the patient's blood out of the body for purification and then reinfuses it back into the human body. Adsorbents used to purify blood are placed in the perfusion device used for hemoperfusion; when used, it is set in the blood circuit of extracorporeal circulation, blood passes through it, and the target substance is adsorbed by the adsorbent and retained in the perfusion device to purify the blood . [0003] Blood anticoagulation is one of the basic conditions to ensure the smooth progress of the treatment process. At present, the most widely used anticoagulants are heparin, low molecular weight heparin, sodium citrate and the new generation anticoagulant hirudin, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36A61M1/00
CPCA61L33/0011A61L33/0064A61L33/064A61L2300/236A61L2300/42A61L2300/602A61M1/3672A61M1/38C08L33/24
Inventor 董凡陈坤
Owner JAFRON BIOMEDICAL
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