Blood coagulation function index detection test paper and preparation and signal processing method thereof

A technology for detecting test strips and coagulation function, applied in the field of detection, can solve the problems of time-consuming, high cost, complicated detection of coagulation function indicators, etc., and achieve the effect of low cost

Active Publication Date: 2021-05-04
HUNAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a blood coagulation detection test paper in view of the defi

Method used

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  • Blood coagulation function index detection test paper and preparation and signal processing method thereof
  • Blood coagulation function index detection test paper and preparation and signal processing method thereof
  • Blood coagulation function index detection test paper and preparation and signal processing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] This embodiment provides the structure and preparation method of the test paper for detecting blood coagulation indicators.

[0058] Such as figure 1 , a coagulation index test paper with one end as a sample collection end and the other end as an electrode contact end. The test paper includes a base layer, an intermediate spacer layer and a hydrophilic layer, and the base layer is provided with an organic electrochemical transistor, and the organic electrochemical transistor includes a source electrode 1 , a drain electrode 2 , a gate electrode 3 and an organic semiconductor film 4 . The base layer is an insulating material, and as the insulating substrate of the organic electrochemical transistor, the source electrode 1, the drain electrode 2 and the gate electrode 3 are coated on the insulating substrate, and the source electrode 1, the drain electrode 2 and the gate electrode The electrodes 3 are parallel to each other and do not intersect each other. An organic sem...

Embodiment 2

[0065] The present invention provides the test paper described in Example 1 for detecting prothrombin time (PT).

[0066] S1. Deposit noble metal gold by magnetron sputtering on the insulating substrate of the base layer, the thickness of the gold film is 100nm, prepare the source electrode 1, the drain electrode 2 and the gate electrode 3 with gold as the conductive material, on the source electrode 1, the leakage current Surface-modified poly(3,4-ethylenedioxythiophene)-polystyrenesulfonic acid organic semiconductor film 4 of electrode 2: spin-coated poly(3,4-ethylenedioxythiophene)-polystyrenesulfonic acid solution on the source Films were formed on electrode 1 and drain electrode 2, and then annealed at 180°C for 30 minutes in a nitrogen atmosphere, so that the poly(3,4-ethylenedioxythiophene)-polystyrenesulfonic acid organic semiconductor film was firmly attached to the electrode surface. 2.0 microliters of PT reaction membrane solution was added dropwise on the surface o...

Embodiment 3

[0074] When producing test papers in large quantities, due to the instability of the production process, there will be performance differences between different test papers. When encountering problematic test papers, the consistency and accuracy of the test papers will be significantly reduced. In order to reduce the difference in performance between test strips, especially reduce the influence of problematic test strips, and improve the consistency and accuracy of mass-produced test strips, the performance of test strips can be improved through algorithm optimization. In this example, with the use of T S Compared with the algorithm for signal processing, the algorithm using △T for signal processing can significantly improve the accuracy and consistency of test paper measurement, and reduce the influence of problem test paper. The relevant results are shown in Table 2 and Table 3.

[0075] Table 2

[0076]

[0077]

[0078] table 3

[0079]

[0080] It can be seen fro...

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Abstract

The invention discloses blood coagulation function index detection test paper and a preparation and signal processing method thereof. The blood coagulation function index detection test paper comprises a substrate layer, a middle interlayer and a hydrophilic layer, wherein the middle interlayer is adhered between the substrate layer and the hydrophilic layer, the substrate layer is provided with an organic electrochemical transistor containing a reaction film for detecting blood coagulation function indexes, and the middle interlayer is provided with a sample introduction channel to the organic electrochemical transistor reaction region. The current change trend of the organic electrochemical transistor is used for reflecting blood coagulation states in different stages, and the current change time inflection point is determined by detecting the current change in different blood coagulation states, so that the detection of blood coagulation function indexes is realized. The invention further provides a signal processing method for improving the precision and accuracy of the test paper for measuring a blood coagulation function index, and reducing the difference of the performance of the test paper, which is influenced by the instability of the production process.

Description

technical field [0001] The invention relates to the technical field of detection, and more specifically, to a blood coagulation function index detection test paper, a preparation method and a signal processing method thereof. Background technique [0002] Coagulation function test is a common detection item in clinical practice and an important indicator reflecting the coagulation mechanism. It has high medical application value in the diagnosis and treatment of thrombotic, bleeding and other diseases as well as in the operation process. At present, the common coagulation function test indicators are mainly prothrombin time (PT), activated partial thromboplastin time (APTT), activated coagulation time (ACT), fibrinogen content (FIB) and thrombin time (TT). Accurate detection of the above indicators has important guiding significance for the diagnosis and treatment of coagulation dysfunction. [0003] The detection of coagulation function in clinical practice is mainly carri...

Claims

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Application Information

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IPC IPC(8): G01N27/414
CPCG01N27/4145Y02E10/549
Inventor 黄钊贾学恩汤建新
Owner HUNAN UNIV OF TECH
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