Blood coagulation function index detection test paper and preparation and signal processing method thereof
A technology for detecting test strips and coagulation function, applied in the field of detection, can solve the problems of time-consuming, high cost, complicated detection of coagulation function indicators, etc., and achieve the effect of low cost
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Embodiment 1
[0057] This embodiment provides the structure and preparation method of the test paper for detecting blood coagulation indicators.
[0058] Such as figure 1 , a coagulation index test paper with one end as a sample collection end and the other end as an electrode contact end. The test paper includes a base layer, an intermediate spacer layer and a hydrophilic layer, and the base layer is provided with an organic electrochemical transistor, and the organic electrochemical transistor includes a source electrode 1 , a drain electrode 2 , a gate electrode 3 and an organic semiconductor film 4 . The base layer is an insulating material, and as the insulating substrate of the organic electrochemical transistor, the source electrode 1, the drain electrode 2 and the gate electrode 3 are coated on the insulating substrate, and the source electrode 1, the drain electrode 2 and the gate electrode The electrodes 3 are parallel to each other and do not intersect each other. An organic sem...
Embodiment 2
[0065] The present invention provides the test paper described in Example 1 for detecting prothrombin time (PT).
[0066] S1. Deposit noble metal gold by magnetron sputtering on the insulating substrate of the base layer, the thickness of the gold film is 100nm, prepare the source electrode 1, the drain electrode 2 and the gate electrode 3 with gold as the conductive material, on the source electrode 1, the leakage current Surface-modified poly(3,4-ethylenedioxythiophene)-polystyrenesulfonic acid organic semiconductor film 4 of electrode 2: spin-coated poly(3,4-ethylenedioxythiophene)-polystyrenesulfonic acid solution on the source Films were formed on electrode 1 and drain electrode 2, and then annealed at 180°C for 30 minutes in a nitrogen atmosphere, so that the poly(3,4-ethylenedioxythiophene)-polystyrenesulfonic acid organic semiconductor film was firmly attached to the electrode surface. 2.0 microliters of PT reaction membrane solution was added dropwise on the surface o...
Embodiment 3
[0074] When producing test papers in large quantities, due to the instability of the production process, there will be performance differences between different test papers. When encountering problematic test papers, the consistency and accuracy of the test papers will be significantly reduced. In order to reduce the difference in performance between test strips, especially reduce the influence of problematic test strips, and improve the consistency and accuracy of mass-produced test strips, the performance of test strips can be improved through algorithm optimization. In this example, with the use of T S Compared with the algorithm for signal processing, the algorithm using △T for signal processing can significantly improve the accuracy and consistency of test paper measurement, and reduce the influence of problem test paper. The relevant results are shown in Table 2 and Table 3.
[0075] Table 2
[0076]
[0077]
[0078] table 3
[0079]
[0080] It can be seen fro...
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