Directionally driven targeted hemostasis micromotor and preparation method thereof

A micro-motor and targeted technology, applied in the fields of pharmaceutical formulations, applications, and pharmaceutical sciences, can solve the problems of wound limitation of application, limitation of coagulation function of hemostatic agents, and difficulty in controlling blood loss, etc., and achieves high surface potential and good biological phase. Capacitive, high specific surface area effect

Inactive Publication Date: 2021-06-04
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the buoyancy of the gas, the propulsion of the carrier is upward, which means that the particles in the wound will only be transported upward; this kinetic behavior limits the application of particles in many kinds of bleeding wounds
In addition, during the process of acidolysis reaction, the loss of the surface layer of calcium carbonate particles makes the thrombin continue to disperse and release. Risks introduced into the circulatory system
[0008] Generally speaking, for deep, penetrating and cavity wound bleeding, it is difficult for the existing hemostatic materials to reverse the blood flow a

Method used

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  • Directionally driven targeted hemostasis micromotor and preparation method thereof
  • Directionally driven targeted hemostasis micromotor and preparation method thereof
  • Directionally driven targeted hemostasis micromotor and preparation method thereof

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Embodiment 1

[0041] The present invention is directed to driving the preparation method of targeting the hemostatic micromotor, the preparation process is figure 1 As shown, including the following steps:

[0042] Step a) Nano Fe 3 O 4 Self-assembly on micro-pore starch:

[0043] 0.48 g of micro-pure starch was added to aqueous methane trimethylammonium bromide, and the mass ratio of microporous starch and tetraalkyl trimethylammonium bromide was 0.01: 160-1: 160w / v, at 40-70 EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc. 2 The mixture was added to 50-500 μl of the solution, stirred for 5-60min, and sufficiently adsorbing the microporous starch. 2+ Then, the concentration of 0.007 mol / 5ml was added dropwise. 2 O 2 25-300 μL of solution, oxidized portion Fe 2+ After 5-10 min, aqueous NaOH aqueous solution or ammonia was added dropwise until pH = 8-10, resulting in a precipitated microporous starch / nanometer Fe. 3 O 4 -1 particles; synthetic particles with 75% alcohol thorns, then stand for 1-10 min, ...

Embodiment 2

[0056] The preparation method of the present invention is directed to the preparation of the hemostatic micromotactic hemostasis, the operation steps are as follows:

[0057] a) Nano Fe 3 O 4 Self-assembly on microporous starch

[0058] 0.48 g of micro-pore starch was added to aqueous cencetaxyl trimethylammonium bromide (0.01: 160, w / v) aqueous solution, and nitrogen gas was 10 min at 60 ° C to exclude air. 400μL FeCl 2 Solution (0.01 mol / 5 mLHCl solution (0.01 mol / 5 mL)) was added to the above mixture for 20 min, and the microporous starch was sufficiently adsorbed. 2+ . Then, quickly drop H. 2 O 2 (0.007 mol / 5mL) solution, oxidized part of Fe 2+ . After 5 min, NaOH (1 ml, 0.056 g / ml) aqueous solution was dripped until pH = 9, and finally the precipitated microporous starch / nanometer Fe 3 O 4 -1 particles. Synthetic microporous starch / nanometer Fe 3 O 4 -1 particles with 75% alcohol thorns to wash, then stand for 5 min, remove excess chemical reagents and free Fe 3...

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Abstract

The invention provides a directionally driven targeted hemostasis micromotor, which is characterized in that microporous starch is used as a carrier for delivering a hemostasis drug, nano Fe3O4 is self-assembled on the surface of the microporous starch to serve as a power system, and the hemostasis drug (thrombin) is loaded on the surface of the microporous starch/nano Fe3O4 by using bovine serum albumin. The thrombin on the micromotor can stably exist on the carrier, and under the stimulation of a magnetic field, the effect of centralized and directional delivery is achieved, so that the blood coagulation function of the thrombin is fully played; and meanwhile, under the stimulation of an external magnetic field, the micromotor can generate power to move towards a target position, and when the position of the magnetic field is changed, the movement direction of the micro motor can be changed, so that the micromotor is suitable for various types of wound surfaces and wounds.

Description

Technical field [0001] The present invention belongs to the technical field of biomedicine materials, and in particular, the present invention relates to a directional drive targeting hemostatic micromotel and a preparation method thereof. Background technique [0002] Excessive blood loss caused by surgery, accidental trauma and war is one of the main causes of global mortality. The data shows that the death of more than 580 million people worldwide is caused by uncontrolled blood loss. The damaged tissue wound type will directly affect the effective treatment of bleeding wound. For epithelial blood, the treatment of drugs such as sponge, powder, hydrogel, thrombin, and so on can be quickly delivered to the damaged blood vessels. However, for special depth, penetration, and cavity wound bleeding, routine hematics are difficult to move through narrow and deep traumatic passages to impaired blood vessels. According to statistics, in all cases of death, deep, penetrated and cavity ...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/02A61L24/10A61L24/00
CPCA61L24/08A61L24/02A61L24/108A61L24/001A61L24/0015A61L24/0036A61L2400/04A61L2400/12A61L2300/254A61L2300/418
Inventor 蓝广芊史正慧胡恩岭陆飞谢瑞琪余堃
Owner SOUTHWEST UNIVERSITY
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