Directionally driven targeted hemostasis micromotor and preparation method thereof

Abstract

The invention provides a directionally driven targeted hemostasis micromotor, which is characterized in that microporous starch is used as a carrier for delivering a hemostasis drug, nano Fe3O4 is self-assembled on the surface of the microporous starch to serve as a power system, and the hemostasis drug (thrombin) is loaded on the surface of the microporous starch / nano Fe3O4 by using bovine serum albumin. The thrombin on the micromotor can stably exist on the carrier, and under the stimulation of a magnetic field, the effect of centralized and directional delivery is achieved, so that the blood coagulation function of the thrombin is fully played; and meanwhile, under the stimulation of an external magnetic field, the micromotor can generate power to move towards a target position, and when the position of the magnetic field is changed, the movement direction of the micro motor can be changed, so that the micromotor is suitable for various types of wound surfaces and wounds.

Description

Technical field [0001] The present invention belongs to the technical field of biomedicine materials, and in particular, the present invention relates to a directional drive targeting hemostatic micromotel and a preparation method thereof. Background technique [0002] Excessive blood loss caused by surgery, accidental trauma and war is one of the main causes of global mortality. The data shows that the death of more than 580 million people worldwide is caused by uncontrolled blood loss. The damaged tissue wound type will directly affect the effective treatment of bleeding wound. For epithelial blood, the treatment of drugs such as sponge, powder, hydrogel, thrombin, and so on can be quickly delivered to the damaged blood vessels. However, for special depth, penetration, and cavity wound bleeding, routine hematics are difficult to move through narrow and deep traumatic passages to impaired blood vessels. According to statistics, in all cases of death, deep, penetrated and cavity ...

AI Technical Summary

Problems solved by technology

However, due to the buoyancy of the gas, the propulsion of the carrier is upward, which means that the particles in the wound will only be transported upward; this kinetic behavior limits the application of particles in many kinds of bleeding wounds

In addition, during the process of acidolysis reaction, the loss of the surface layer of calcium carbonate particles makes the thrombin continue to disperse and release. Risks introduced into the circulatory system

[0008] Generally speaking, for deep, penetrating and cavity wound bleeding, it is difficult for the existing hemostatic materials to reverse the blood flow and penetrate deep into the wound to achieve targeted hemostasis in the face of a large blood flow impact, resulting in Severe restriction of the clotting function of the hemostat, which increases the difficulty of controlling blood loss

However, the self-propelled calcium carbonate carrier system developed at this stage has some shortcomings, such as: the wound surface of the application is limited, the thrombin cannot be concentrated at the bleeding point to fully exert the coagulation function, and the dispersed released thrombin and residual calcium carbonate exist. Risks introduced into the circulatory system

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