Method for synthesizing isopropamide

A technology for isopropylamine and isopropyl alcohol, applied in the field of isopropylamine production, can solve the problems of affecting catalyst selectivity, affecting catalyst life, low conversion efficiency, etc., and achieves the effects of simplifying production process flow, generating less amount, and improving conversion efficiency.

Active Publication Date: 2010-11-10
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, if it is difficult for reactant molecules to enter the deep pores of the catalyst, the utilization rate of nickel distributed in the deep pores may be low, that is to say, the conversion efficiency of the existing nickel-based catalysts with uniform distribution of nickel componen

Method used

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  • Method for synthesizing isopropamide

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Embodiment 1

[0024] Nickel nitrate hexahydrate is dissolved in ammonia water to make an impregnating solution. The ammonia water used is mixed with commercially available 25% to 28% ammonia water and water at a weight ratio of 1:0.5, and the spherical alumina carrier is impregnated by an equal impregnation method. The alumina carrier is produced by Beijing Research Institute of Chemical Industry, with a specific surface area of ​​250m2 / g, the pore volume is 0.44ml / g, dried at 120°C for 4 hours, calcined at 420°C for 4 hours, and then reduced with hydrogen at 350°C for 8 hours to prepare catalyst A, by weight of the catalyst, containing 10% nickel by weight. Cutting the catalyst ball particles in half, it can be clearly seen that the nickel component is distributed from the surface of the support to the catalyst body at a depth of 0.7 mm, and basically no nickel component can be seen in the spherical core region with a depth greater than 0.7 mm.

Embodiment 2

[0026] Nickel nitrate hexahydrate is dissolved in ammonia water to make impregnating solution. The ammonia water used is mixed with commercially available 25%-28% ammonia water and water at a weight ratio of 1:0.3, and the spherical alumina carrier is impregnated by an equal impregnation method. The alumina carrier is produced by Beijing Research Institute of Chemical Industry, with a specific surface area of ​​274m 2 / g, the pore volume is 0.45ml / g, first dry at 60°C for 4 hours, then dry at 120°C for 4 hours, then bake at 420°C for 4 hours, then impregnate again, dry, bake, and use hydrogen Reduction at 375° C. for 8 hours prepared Catalyst B, which contained 20% by weight of nickel based on the weight of the catalyst. Cutting the catalyst ball particles in half, it can be clearly seen that the nickel component is distributed from the surface of the support to the catalyst body at a depth of 0.7 mm, and basically no nickel component can be seen in the spherical core region w...

Embodiment 3

[0028] Dissolve nickel nitrate hexahydrate in ammonia water to make impregnation solution. The ammonia water used is mixed with commercially available 25%-28% ammonia water and water at a weight ratio of 1:0.1, and the spherical alumina carrier is sprayed by spraying method. The carrier is produced by Beijing Research Institute of Chemical Industry, with a specific surface area of ​​264m 2 / g, the pore volume is 0.45ml / g, first dry at 60°C for 4 hours, then dry at 120°C for 4 hours, then bake at 420°C for 4 hours, then repeat the above process, and finally use hydrogen at 375°C After 8 hours of reduction, catalyst C was prepared, which contained 22% by weight of nickel based on the weight of the catalyst. Cutting the catalyst ball particles in half, it can be clearly seen that the nickel component is distributed from the surface of the support to the catalyst body at a depth of 0.7 mm, and no nickel component can be seen in the spherical core region with a depth greater than 0...

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Abstract

The invention discloses a method for synthesizing isopropamide, belonging to the technical field of synthesizing fatty amine. In order to improve the conversion efficiency and the selectivity of catalysts for synthesizing isopropamide, propanone or isopropanol is used as the raw material, in the presence of hydrogen and a nickel-based catalyst, amination is carried out to synthesize isopropamide under the conditions that the reaction temperature is 110-200 DEG C, the reaction pressure is 0.1-1.0MPa, and the mole ratio of propanone or isopropanol to hydrogen to ammonia is 1:(1-5):(1-5), wherein the catalyst contains a carrier and nickel active components loaded on the carrier, and over 90 percent of the nickel active components are distributed in a region with the depth of 0.7 mm from the surface of the carrier. The method in the invention can ensure that the conversion efficiency of the propanone is improved, has higher propanone conversion efficiency under the condition of same nickel content and better selectivity, reduces the generation amount of diisopropylamine, simplifies the production process flows of the isopropamide, and lowers the production cost of the isopropamide.

Description

technical field [0001] The present invention relates to a kind of method of producing lower aliphatic amine, more specifically, the present invention relates to a kind of method of producing isopropylamine. Background technique [0002] Isopropylamine is an important raw material for the production of various pesticides such as atrazine, isofenphos-methyl and buprofezin; it can also be used for the production of detergents such as isopropylamine dodecylbenzenesulfonate; in the rubber industry and It is also widely used in the pharmaceutical industry. [0003] People have done a lot of research on the production methods of isopropylamine, and some of them have been maturely applied in industry. Wherein mainly contain: (1) isopropanol gas-phase ammoniation method, this method is with isopropanol as raw material, in the presence of copper, nickel or cobalt catalyst, isopropanol and ammonia react to generate isopropylamine under the condition of facing hydrogen, as the United S...

Claims

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Application Information

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IPC IPC(8): C07C211/06C07C209/26C07C209/16B01J23/755
Inventor 田保亮戴伟唐国旗李宝芹张桂英张齐
Owner CHINA PETROLEUM & CHEM CORP
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