Amino acid-based polyesteramide / poly (lactic-co-glycolic acid) fiber membrane as well as preparation method and application thereof
Amino acid-based polyesteramide/poly(lactic acid) fiber membranes were prepared using electrospinning technology. These membranes, loaded with protein-based hypoglycemic drugs, solved the problems of poor wound healing and high risk of postoperative adhesion in diabetic patients, achieving localized, highly effective blood sugar reduction and rapid healing.
CN122141026APending Publication Date: 2026-06-05ENERGY RESOURCES INST HEBEI ACADEMY OF SCI
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Patent Information
- Application Number
- CN202411780830.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-05
- Publication Date
- 2026-06-05
AI Technical Summary
Technical Problem
Diabetic patients have poor wound healing outcomes, a high risk of postoperative adhesions, and lack effective treatment options.
Method used
Amino acid-based polyesteramide/poly(lactic acid) fiber membranes were prepared using electrospinning technology. These membranes, loaded with protein-based hypoglycemic drugs, exhibit good biocompatibility and wound-healing properties.
Benefits of technology
It achieves localized, efficient, and sustained blood sugar reduction, promotes rapid wound healing in diabetic patients after surgery, prevents postoperative adhesions, and is suitable for anti-adhesion isolation materials.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to a preparation method of an amino acid-based polyesteramide / poly (lactic-co-glycolic acid) fiber membrane. The fibrous membrane is prepared by the following steps: adding a protein hypoglycemic drug into a 0.2-0.5 g / ml amino acid-based polyesteramide solution to obtain a drug-loaded nano-composite, then adding the drug-loaded nano-composite into a 0.2-0.5 g / ml poly (lactic-co-glycolic acid) solution, and carrying out an electrostatic spinning technology, and the volume ratio of the amino acid-based polyesteramide drug-loaded nano-composite to the poly (lactic-co-glycolic acid) solution is (0.5-2): 5. The fibrous membrane disclosed by the invention has very high porosity, has very good fitness when being implanted into the body of a patient, prevents the risk of postoperative adhesion, and can effectively promote rapid healing of a postoperative wound of a diabetic patient; in addition, the preparation method of the fiber membrane is simple, and the fiber membrane has good application in preparation of a diabetes wound repair material.
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