Anti-adhesion material with hemostatic, antibacterial and healing promotion functions and preparation method thereof

An anti-adhesion and functional technology, applied in the field of biomedical materials, can solve the problems of anti-adhesion film that is difficult to degrade, unsuitable for high-incidence wounds with adhesions, small molecule cross-linking agent residues, etc., to achieve easy molding, good clinical application prospects, and promote wound healing healing effect

Active Publication Date: 2018-04-20
安徽中科迈德医疗科技有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Chinese patent 201410580360.3 discloses a medical injectable anti-adhesion gel and its preparation method. This anti-adhesion gel formed in situ by a double injection device has the advantages of long retention in the body and convenient use. However, the use of this patent When the prepared gel is degraded, it will cause the problem of residual small molecule cross-linking agent in the body, causing safety hazards, which is not conducive to clinical promotion and use
However, the anti-adhesion film has two disadvantages: on the one hand, the anti-adhesion film uses genipin with a strong cross-linking ability as a crosslinking agent, which may make the anti-adhesion film difficult to degrade and increase the risk of clinical use; On the one hand, bacterial infection is also one of the main causes of tissue adhesion, especially for bloody wounds that exist in a moist environment with a large amount of interstitial fluid
However, the anti-adhesion film does not have antibacterial function, and its clinical application is limited.
Chinese patent 201610870752.2 discloses an anti-adhesion material with antibacterial and healing-promoting functions and its preparation method. Although this gel material with temperature-sensitive properties shows good anti-adhesion effects in the secondary release of adhesions, but Fibrin deposition caused by hemorrhage is one of the main causes of adhesions. Due to the lack of hemostatic properties, the above-mentioned patented products are not suitable for high-adhesion wounds with more bleeding
[0004] In summary, the current market lacks a biosafety anti-adhesion material that has the functions of hemostasis, antibacterial, and wound healing.

Method used

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  • Anti-adhesion material with hemostatic, antibacterial and healing promotion functions and preparation method thereof
  • Anti-adhesion material with hemostatic, antibacterial and healing promotion functions and preparation method thereof
  • Anti-adhesion material with hemostatic, antibacterial and healing promotion functions and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] (1) Dissolve a hyaluronic acid derivative with a molecular weight of 1 million in water at 4°C to obtain 10 mL of a hyaluronic acid derivative solution with a mass-to-volume ratio of 0.05%;

[0046] (2) Dissolve the aminodextran derivative with a molecular weight of 200,000 in water at 4°C to obtain 10 mL of the aminodextran derivative solution with a mass-volume ratio of 50%;

[0047] (3) Mix the hyaluronic acid derivative solution obtained in step (1) with the aminodextran derivative solution obtained in step (2) at a volume ratio of 20:1 under stirring at 4°C, and then mix the above mixed solution It was allowed to stand at -20°C for 48 hours, and then vacuum freeze-dried for 96 hours at a temperature of -45°C and a vacuum of 5 Pascals, thereby dehydrating the material to obtain an anti-adhesion sponge.

Embodiment 2

[0049] (1) Dissolve the sodium alginate derivative with a molecular weight of 800,000 in water at 4°C to obtain 10 mL of a sodium alginate derivative solution with a mass-to-volume ratio of 50%;

[0050] (2) Dissolving an oxidized hyaluronic acid derivative with a molecular weight of 300,000 in water at 4°C to obtain 10 mL of an oxidized hyaluronic acid derivative solution with a mass-to-volume ratio of 0.05%;

[0051] (3) The sodium alginate derivative solution obtained in step (1) and the oxidized hyaluronic acid derivative solution obtained in step (2) were mixed at a volume ratio of 2:8 under stirring at 4 °C, and then 0.2 mL mass fraction was added. A 0.5% sorbitol solution was slowly added dropwise to the mixed solution and allowed to stand at 4°C for 30 minutes. Subsequently, the above mixed solution added with sorbitol was allowed to stand at -20°C for 48h, and then vacuum freeze-dried for 96h at a temperature of -45°C and a vacuum degree of 5 Pascals, and finally an a...

Embodiment 3

[0053] (1) Dissolve a cellulose derivative with a molecular weight of 600,000 in water at 4°C to obtain 10 mL of a cellulose derivative solution with a mass-volume ratio of 3%;

[0054] (2) Dissolving the aminated Bletilla striata polysaccharide derivative with a molecular weight of 300,000 in water at 4° C. to obtain 10 mL of a 6% mass-volume ratio of the aminated Bletilla striata polysaccharide derivative solution;

[0055] (3) Mix the cellulose derivative solution obtained in step (1) with the amino acid Bletilla striata polysaccharide derivative solution obtained in step (2) at a volume ratio of 5:5 under stirring at 4°C, and then the mixed solution was changed from 300 Filter through mesh sieve, defoaming under reduced pressure, and cast film after standing at room temperature to obtain an anti-adhesion film.

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Abstract

The invention provides a novel anti-tissue-adhesion material and a preparation method thereof. Used raw materials are from natural polysaccharides and modified natural polysaccharides; the use of micromolecular cross linking agents is avoided; and the excellent biosecurity is realized. A compound prepared from the natural polysaccharides and the modified natural polysaccharides through chemical reaction can be used for the anti-adhesion purpose in positions such as the pelvic cavity, the abdominal cavity, the achilles tendon and nerves. Meanwhile, the hemostatic, antibacterial and healing promotion functions are realized. The anti-adhesion material provided by the invention can be prepared into anti-adhesion sponge, anti-adhesion films and anti-adhesion gel through different process conditions; the surgical operation convenience is high; good clinic application prospects are realized.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a degradable anti-adhesion material with the functions of hemostasis, antibacterial and wound healing that directly acts on bloody wounds such as humans and mammals and a preparation method thereof. Background technique [0002] Postoperative adhesion refers to the abnormal fibrous connection between tissues and organs during the tissue healing process after surgical trauma. Adhesion after surgery is one of the unresolved problems in medicine for a long time. Theoretically speaking, almost all postoperative injury and healing processes will involve tissue adhesion. Tissue adhesion is a common complication in surgery, but its consequences should not be underestimated. Tissue adhesion can lead to various complications including small bowel obstruction, infertility, and chronic abdominal and pelvic pain. It will increase the difficulty and risk of the operation, cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/16
CPCA61L31/042A61L31/141A61L31/148A61L31/16A61L2300/41A61L2300/418A61L2300/604
Inventor 石长灿冯亚凯刘雯陈浩杨啸李娜席光辉
Owner 安徽中科迈德医疗科技有限公司
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