Bacterial cellulose/chitosan composite medical dressing and preparation method thereof

A technology of bacterial cellulose and bacterial fiber, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of limited tensile deformation capacity, liquid absorption capacity, and insufficient strength, so as to promote wound healing, high tensile strength, The effect of strong shape maintenance ability

Inactive Publication Date: 2013-04-24
上海昌颌医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a bacterial cellulose / chitosan composite medical dressing and its preparation method. The preparation process of the method is simple and the process control is easy. The prepared bacterial cellulose / chitosan composite medical dressing The dressing not only has the advantages of chitosan medical dressing for hemostasis, anti-inflammation, sterilization, promotion of wound healing, and no scars, but also has the advantages of high tensile strength of bacterial cellulose, high water holding capacity, high water permeability, and strong shape maintenance ability. The disadvantages of conventional chitosan nonwoven dressings are insufficient strength, limited tensile deformation ability and liquid absorption capacity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The bacterial cellulose membrane with a degree of polymerization of 800 was boiled with 1% NaOH aqueous solution at 80 °C for 45 min, then fully washed with distilled water until neutral (pH=7.0), and vacuum-dried at 75 °C for 12 h. Use a ball mill to grind to a length of 6.5mm and a specific surface area of ​​500m 2 / g of fibrids.

[0027] Chitosan sheet is placed in 2% (mass fraction) acetic acid, let stand for more than 4 hours, then add glacial acetic acid and make wherein acetic acid content reaches 4%, be dubbed as the shell that content is 3% (mass fraction) through stirring polysaccharide solution. The bacterial cellulose fibrids are added to the chitosan solution in an amount of 15% of the dry weight of the chitosan, and left to stand for defoaming.

[0028] The above-mentioned chitosan solution added with bacterial cellulose fibrids is covered on the surface of the chitosan nonwoven fabric by casting. The bacterial cellulose / chitosan composite medical dress...

Embodiment 2

[0030] The bacterial cellulose membrane with a degree of polymerization of 1000 was boiled with 1% NaOH aqueous solution at 100 °C for 30 min, then washed with distilled water until neutral (pH = 7.0), and vacuum-dried at 75 °C for 12 h. Use a ball mill to grind to a length of 5.5mm and a specific surface area of ​​600m 2 / g of fibrids.

[0031] The chitosan sheet was placed in 3% (mass fraction) acetic acid, left to stand for more than 4 hours, and then stirred to form a chitosan solution with a content of 3% (mass fraction). The bacterial cellulose fibrids are added to the chitosan solution in an amount of 10% of the dry weight of the chitosan, and left standing for defoaming.

[0032] The above-mentioned chitosan solution added with bacterial cellulose fibrids is covered on the surface of the chitosan paper by casting. The bacterial cellulose / chitosan composite medical dressing is obtained by solidifying with a 15% sodium hydroxide solution and drying at a temperature of ...

Embodiment 3

[0034] The bacterial cellulose membrane with a degree of polymerization of 3000 was boiled with 1% NaOH aqueous solution at 80 °C for 60 min, then washed with distilled water until neutral (pH = 7.0), and vacuum-dried at 75 °C for 12 h. Use a ball mill to grind to a length of 9.5mm and a specific surface area of ​​400m 2 / g of fibrids.

[0035] Chitosan tablets were placed in 1-butyl-3-methyl imidazole chloride [C 4 In MIM]Cl, let stand more than 8 hours, be made into the chitosan solution that content is 9% (mass fraction) through stirring. The bacterial cellulose fibrids are added to the chitosan solution in an amount of 20% of the dry weight of the chitosan, and left to stand for defoaming.

[0036] The above-mentioned chitosan solution added with bacterial cellulose fibrids is covered on the surface of the chitosan nonwoven fabric by casting. After water curing and drying at a temperature of 170°C, the bacterial cellulose / chitosan composite medical dressing can be obtai...

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Abstract

The invention relates to a bacterial cellulose/chitosan composite medical dressing and a preparation method thereof. The bacterial cellulose/chitosan composite medical dressing comprises the following components in percentage by mass: 1-20% of bacterial cellulose and 80-99% of chitosan. The preparation method comprises the following steps: (1) boiling a bacterial cellulose membrane by using a NaOH aqueous solution, washing the bacterial cellulose membrane to a neutral state, drying the bacterial cellulose membrane in a vacuum state and grinding the bacterial cellulose membrane into a fibrid; and (2) adding the bacterial cellulose fibrid to a chitosan solution, standing and defoaming the bacterial cellulose fibrid, pouring and covering the bacterial cellulose fibrid on the surface of a chitosan medical dressing, curing the medical dressing by using a coagulating bath, and washing and drying the medical dressing so as to obtain the bacterial cellulose/chitosan composite medical dressing. According to the invention, the excellent characteristics of the chitosan medical dressing can be kept and the strength, ventilating property and hydrophilcity of the chitosan medical dressing can be improved; and the bacterial cellulose/chitosan composite medical dressing provided by the invention has the advantages of simple process and easiness for controlling the process.

Description

technical field [0001] The invention belongs to the field of medical dressings and preparation thereof, in particular to a bacterial cellulose / chitosan composite medical dressing and a preparation method thereof. Background technique [0002] Medical dressings are materials used to treat wounds. In the case of minor burns (first and second degree), the wound site is usually covered with a medical dressing to inhibit the evaporation of body fluids and prevent the invasion of bacteria. In case of severe burns (third degree), artificial skin should be used. [0003] The main functions of medical dressings are reflected in the following aspects: ① control the exudate of the wound; ② avoid or control the infection of the wound; ③ remove or control the odor produced by the wound; ④ relieve pain; ⑤ ensure the comfort of the patient as much as possible ;⑥Conceal the wound to protect the injured person's need for beauty; ⑦Make the wound heal quickly and make the wound surface have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/42
Inventor 沈新元赖东风
Owner 上海昌颌医药科技有限公司
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