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Preparation method of porous sodium alginate nano-fiber wound dressing

A sodium alginate and nanofiber technology, applied in the field of sanitary materials, to achieve excellent water absorption and water holding properties, high specific surface area and porosity, and the effect of promoting cell respiration

Inactive Publication Date: 2015-03-25
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Xie Hong etc. used the calcium chloride / absolute ethanol solution with a mass fraction of 3% as a cross-linking agent to carry out moxifloxacin hydrochloride polyvinyl alcohol / Sodium alginate electrospun nanofibers were cross-linked, and the drug-loaded fibers were released in vitro. The results showed that the drug release rate slowed down with the increase of cross-linking time.

Method used

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  • Preparation method of porous sodium alginate nano-fiber wound dressing
  • Preparation method of porous sodium alginate nano-fiber wound dressing
  • Preparation method of porous sodium alginate nano-fiber wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh 8 grams of PVA and add 100ml of deionized water, stir magnetically in a water bath at 80°C for 2 hours to dissolve the PVA to form a transparent solution, add 1 gram of sodium alginate after cooling to room temperature, stir magnetically for 1 hour to dissolve and form a transparent solution, then add 0.18 grams of carbonic acid ammonium hydrogen, stirred and dissolved to obtain spinning solution.

[0039]The spinning liquid is loaded into the liquid storage device, and the sodium alginate composite nanofiber membrane material is prepared by using the electrospinning device. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm.

[0040] The prepared sodium alginate composite nanofiber membrane material was vacuum dried in a vacuum oven for 2 days. Then transfer to a blast drying oven, heat treatment at 50° C. for 24 hours to obtain a porous sodium alginate nanofiber membrane.

[0041] The porous sodium alginate nanofibrous membrane material...

Embodiment 2

[0043] Weigh 10 grams of gelatin and add 100ml of deionized water, stir magnetically in a water bath at 80°C for 2 hours to dissolve the gelatin to form a transparent solution, add 1 gram of sodium alginate after cooling to room temperature, stir magnetically for 1 hour to dissolve and form a transparent solution, then add 0.22 grams of carbonic acid ammonium hydrogen, stirred and dissolved to obtain spinning solution.

[0044] The spinning liquid is loaded into the liquid storage device, and the sodium alginate composite nanofiber membrane material is prepared by using the electrospinning device. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm.

[0045] The prepared sodium alginate composite nanofiber membrane material was vacuum dried in a vacuum oven for 2 days. Then transfer to a blast drying oven, heat treatment at 50° C. for 24 hours to obtain a porous sodium alginate nanofiber membrane.

[0046] The porous sodium alginate nanofibrous membran...

Embodiment 3

[0048] Weigh 10 grams of PEO and add 100ml of deionized water, stir magnetically in a water bath at 80°C for 2 hours to dissolve the PEO to form a transparent solution, add 1 gram of sodium alginate after cooling to room temperature, stir magnetically for 1 hour to dissolve and form a transparent solution, then add 0.22 grams of carbonic acid ammonium hydrogen, stirred and dissolved to obtain spinning solution.

[0049] The spinning liquid is loaded into the liquid storage device, and the sodium alginate composite nanofiber membrane material is prepared by using the electrospinning device. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm.

[0050] The prepared sodium alginate composite nanofiber membrane material was vacuum dried in a vacuum oven for 2 days. Then transfer to a blast drying oven, heat treatment at 50° C. for 24 hours to obtain a porous sodium alginate nanofiber membrane.

[0051] The porous sodium alginate nanofibrous membrane materi...

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Abstract

The invention relates to a preparation method of a porous sodium alginate nano-fiber wound dressing material. The method comprises the following steps: preparing a spinning solution by dissolving sodium alginate and a water-soluble polymer as basic raw materials and a thermal decomposition foaming agent as a porogenic agent in water according to a certain mass ratio, preparing sodium alginate composite nano-fiber by adopting an electrostatic spinning technology, then performing thermal treatment on the nano-fiber at a certain temperature to decompose the foaming agent, and forming holes in and on the surface of the fiber to obtain a porous sodium alginate nano-fiber membrane; and performing chemical crosslinking on the porous sodium alginate nano-fiber membrane in an ethanol solution of CaCl2 to obtain porous sodium alginate nano-fiber wound dressing. The method disclosed by the invention has the advantages of simple preparation process, controllable process conditions and easiness in control of material structure and performance; and the material prepared by the method disclosed by the invention has high specific surface area and porosity, and excellent water absorption and water holding performance, and can be used as the medical wound dressing.

Description

technical field [0001] The invention relates to a preparation method of a porous sodium alginate nanofiber wound dressing, which belongs to the technical field of sanitary materials. Background technique [0002] The use of medical wound dressings as clinical biomaterials has always been a hot topic in research and development. At present, the existing domestic wound dressings mainly include ordinary plant fibers, carboxymethyl cellulose, chitosan, etc.; however, there are many problems such as single product types and functions, no series of products, functional defects, etc., so it is necessary to research and develop A new type of wound dressing and endow it with excellent performance and clinical efficacy. In recent decades, a large number of basic researches and clinical treatments on wounds have verified that providing a suitable moist environment for wounds is conducive to wound healing. The new dressing can not only keep the wound surface moist but also promote ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/26A61L15/44A61L15/42
Inventor 孙复钱王小玉胡银翁雅青
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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