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Preparation method and application of composite porous scaffold

A porous stent and composite material technology, applied in medical science, prosthesis, surgery, etc., can solve the problems of unsatisfactory hydrophilicity and water absorption capacity, poor hemostatic effect, etc., and achieve good water absorption and tissue compatibility. The effect of good performance and excellent mechanical properties

Inactive Publication Date: 2013-03-20
成都维德医疗器械有限责任公司
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  • Abstract
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Problems solved by technology

Although the composite scaffold has excellent biocompatibility and high mechanical strength, it is unsatisfactory in terms of hydrophilicity and water absorption capacity, and the hemostatic effect is not very good in the process of tissue and wound repair.

Method used

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  • Preparation method and application of composite porous scaffold
  • Preparation method and application of composite porous scaffold

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Embodiment Construction

[0035] Hereinafter, the present invention will be further described in detail with reference to the implementation examples and the drawings, but the implementation of the present invention is not limited to this.

[0036] The preparation steps of the composite porous scaffold provided in this embodiment are as follows:

[0037] (1) Preparation of collagen solution: select 20g of natural and non-polluting fresh bovine Achilles tendon, mash it, add 3% acetic acid and 5% (1g) of Achilles tendon mass pepsin, perform enzyme at 4℃ solution. Then centrifuge at 8000 rpm for 30 minutes, take the supernatant, adjust the pH to 7.0 with NaOH, and add solid sodium chloride to make the final concentration of sodium chloride 2.0 mol / L. After standing for 12 hours, centrifuge at 9500 rpm for 30 Minutes, take the precipitate, wash it with distilled water three times and then dissolve it with 1% acetic acid. Finally, dialyzed with distilled water to obtain a higher purity collagen solution, and th...

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Abstract

The invention discloses a method for preparing a composite porous scaffold. According to the method, silk fibroin, collagen and chitosan are compounded together to form the white spongy composite porous scaffold. The porous scaffold prepared by the method can be applied in the technical fields of filling and repair of tissues and wounds, tissue engineering, medicament release and the like. The porosity of the prepared composite porous scaffold reaches more than 98 percent, the size distribution is 50 to 400 microns, and micro pores are intercommunicated. The obtained composite porous scaffold can keep the original form after being soaked into water, has the function of sponge, and can recover the original form after extrusion.

Description

Technical field [0001] The invention relates to a method for preparing a composite porous scaffold, and relates to a technology for preparing a porous scaffold with a structure similar to an extracellular matrix using silk fibroin, collagen and chitosan as raw materials. The prepared porous scaffold has a pore size The diameter is between 50μm and 400μm, which can be used in the filling and repairing of tissues and wounds, as well as tissue engineering, drug release and other technical fields. Background technique [0002] An important aspect of biomedical engineering is the research of scaffold materials. The introduction of suitable scaffold materials is an important factor that promotes the differentiation of cells along the required direction and the formation of tissues, which is conducive to tissue repair. The three-dimensional porous cell scaffold can not only contain cells, cell products and extracellular matrix, but also the basic framework and metabolic site for cell a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/26A61L27/24A61L27/20A61L31/04
Inventor 王松
Owner 成都维德医疗器械有限责任公司
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