Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound guanidine disinfectant and preparation method of compound guanidine disinfectant

A compound guanidine and disinfectant technology, applied in the field of compound guanidine disinfectant and its preparation, can solve the problems of unfavorable wound coating, unfavorable wound healing, inconvenient use and the like, and achieve good synergistic gain and strong adsorption. Killing effect, easy to operate effect

Inactive Publication Date: 2015-11-18
SHANGHAI YUKING NEW MATERIAL TECH
View PDF4 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both iodine and chlorhexidine have poor water solubility. This patent dissolves iodine through potassium iodide and heats to 50°C to dissolve chlorhexidine acetate. However, the instability of iodine and chlorhexidine in aqueous solution is not clearly resolved in this patent. The problem
At the same time, 12%-15% polyvinyl alcohol is used as a film-forming agent, which makes the disinfectant solution very dense, which is not conducive to coating on the wound, and it is very inconvenient to use. Bring some tightness and discomfort to the wound
[0008] Chinese patent CN101095667A discloses a kind of disinfectant for wound disinfection, which uses isopropanol, chlorhexidine, and distilled water as disinfection components. Isopropanol is obviously irritating to the wound, which is not conducive to the healing of the wound, and will also bring a greater physiological burden to the user

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound guanidine disinfectant and preparation method of compound guanidine disinfectant
  • Compound guanidine disinfectant and preparation method of compound guanidine disinfectant
  • Compound guanidine disinfectant and preparation method of compound guanidine disinfectant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0043] According to each component and content shown in the following table 1, compound compound guanidine disinfectant is prepared:

[0044] Table 1

[0045]

[0046] The preparation method of above-mentioned compound guanidine disinfectant comprises the steps:

[0047] Step 1, according to the components of the content, the guanidine disinfectant is added to the surfactant, and stirred until completely dissolved;

[0048] Step 2: Add polymer film-forming agent, low-molecular-weight chitosan, and high-molecular-weight chitosan to 50%-60% of the total water required, after completely dissolving, add penetrating agent and skin care agent in turn, mix and stir evenly ;

[0049] Step 3: Stir the solution obtained in step 2 into the solution in step 1, stir evenly, replenish the remaining water, and adjust the pH value to 7.0-7.5 with a pH regulator.

[0050] All the above-mentioned steps are carried out at normal temperature to obtain the compound guanidine disinfectant for...

Embodiment 5

[0051] Embodiment 5, stability detection

[0052] The compound guanidine disinfectant provided in the above examples is tested according to the stability detection method of the compound disinfectant in the 2002 edition of "Disinfection Technical Standards" and "Hygienic Standards for Guanidine Disinfectants": at a temperature of 37°C, store for 3 months , and detect the effective content of its active ingredients polyhexamethylene biguanide and chlorhexidine acetate or chlorhexidine glucose, and the detection results are shown in Table 2.

[0053] The stability detection result of polyhexamethylene biguanide and chlorhexidine acetate or glucose chlorhexidine in table 2 compound guanidine disinfectant

[0054]

[0055] As can be seen from Table 2, the disinfectant made by the above-mentioned embodiment proportioning and preparation method, through the accelerated stability test in the disinfection technical specification, the active ingredient polyhexamethylene biguanide ...

Embodiment 6

[0056] Embodiment 6, contrast with the disinfection effect of single factor guanidine

[0057] Table 3 shows the comparison of the disinfection effects of the compound guanidine disinfectant of the present invention and other two single-factor guanidine disinfectants polyhexamethylene guanidine and polyhexamethylene biguanide.

[0058] table 3

[0059]

[0060] In Table 3, the compound recipe is the disinfectant of the present invention, using polyhexamethylene biguanide and polyhexamethylene guanidine compound, and monoguanide and biguanide refer to polyhexamethylene guanidine and polyhexamethylene biguanide respectively. The concentration was adjusted to 2000mg / L. It can be clearly seen from the above table that the bactericidal effect of the compound disinfectant is much better than that of the single component. At the same time, in terms of expanding the antibacterial spectrum, Candida albicans, which is highly resistant to guanidine disinfectants, also has a good ki...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a compound guanidine disinfectant, which comprises the following ingredients in percentage by weight: 0.5 to 4.0 percent of guanidine disinfectants, 0.05 to 0.2 percent of low-molecular-weight chitosan, 0.5 to 2.5 percent of high-molecular-weight chitosan, 0.1 to 0.5 percent of Chinese herbal medicine extracts, 0.1 to 1.0 percent of surfactants, 0.1 to 1.0 percent of penetrants, 0.1 to 0.5 percent of skin protectants, 0.1 to 0.5 percent of macromolecule film forming agents and the balance water; and the pH value of the compound guanidine disinfectant is regulated to 7.0 to 7.5 by pH regulating agents. Through the proportional combination of all the ingredients of the compound guanidine disinfectant, a good synergistic effect is achieved; and good sterilization and antibiosis capability is realized on bacterial reproductive bodies, fungi and partial viruses. The invention also provides a preparation method of the compound guanidine disinfectant. The compound disinfectant has the advantages that the preparation process is simple; the operation is convenient; the production cost is low; the scale production is convenient; meanwhile, the property of the disinfectant is stable; and the compound disinfectant is safe and nontoxic and can be easily stored.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a compound guanidine disinfectant for wound disinfection, hemostasis and healing and a preparation method thereof. Background technique [0002] In people's daily home, outdoor, entertainment, and work life, it is inevitable that there will be skin damage and trauma such as abrasions and cuts caused by accidents. The conventional treatment method is to use disinfectants such as alcohol, iodine, and iodophor to sterilize, and then use sterile gauze to bandage and fix the wound. However, this kind of disinfectant is very irritating to the wound, and only has the effect of disinfection and sterilization, and has no effect on the hemostasis and healing of some wounds and wounds. After the disinfection is completed, the wound or wound still needs to be bandaged, otherwise it is easy to cause wound Secondary infection prolongs healing time. Conventional wound dressings use gauze or band-aids, which ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/81A61K47/36A61K9/70A61P17/02A61P31/02A61P31/04A61K31/785A61K31/155A61K31/722
Inventor 王宇朱广东熊俊超陈占
Owner SHANGHAI YUKING NEW MATERIAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products