Compound guanidine disinfectant and preparation method of compound guanidine disinfectant
A compound guanidine and disinfectant technology, applied in the field of compound guanidine disinfectant and its preparation, can solve the problems of unfavorable wound coating, unfavorable wound healing, inconvenient use and the like, and achieve good synergistic gain and strong adsorption. Killing effect, easy to operate effect
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Embodiment 1-4
[0043] According to each component and content shown in the following table 1, compound compound guanidine disinfectant is prepared:
[0044] Table 1
[0045]
[0046] The preparation method of above-mentioned compound guanidine disinfectant comprises the steps:
[0047] Step 1, according to the components of the content, the guanidine disinfectant is added to the surfactant, and stirred until completely dissolved;
[0048] Step 2: Add polymer film-forming agent, low-molecular-weight chitosan, and high-molecular-weight chitosan to 50%-60% of the total water required, after completely dissolving, add penetrating agent and skin care agent in turn, mix and stir evenly ;
[0049] Step 3: Stir the solution obtained in step 2 into the solution in step 1, stir evenly, replenish the remaining water, and adjust the pH value to 7.0-7.5 with a pH regulator.
[0050] All the above-mentioned steps are carried out at normal temperature to obtain the compound guanidine disinfectant for...
Embodiment 5
[0051] Embodiment 5, stability detection
[0052] The compound guanidine disinfectant provided in the above examples is tested according to the stability detection method of the compound disinfectant in the 2002 edition of "Disinfection Technical Standards" and "Hygienic Standards for Guanidine Disinfectants": at a temperature of 37°C, store for 3 months , and detect the effective content of its active ingredients polyhexamethylene biguanide and chlorhexidine acetate or chlorhexidine glucose, and the detection results are shown in Table 2.
[0053] The stability detection result of polyhexamethylene biguanide and chlorhexidine acetate or glucose chlorhexidine in table 2 compound guanidine disinfectant
[0054]
[0055] As can be seen from Table 2, the disinfectant made by the above-mentioned embodiment proportioning and preparation method, through the accelerated stability test in the disinfection technical specification, the active ingredient polyhexamethylene biguanide ...
Embodiment 6
[0056] Embodiment 6, contrast with the disinfection effect of single factor guanidine
[0057] Table 3 shows the comparison of the disinfection effects of the compound guanidine disinfectant of the present invention and other two single-factor guanidine disinfectants polyhexamethylene guanidine and polyhexamethylene biguanide.
[0058] table 3
[0059]
[0060] In Table 3, the compound recipe is the disinfectant of the present invention, using polyhexamethylene biguanide and polyhexamethylene guanidine compound, and monoguanide and biguanide refer to polyhexamethylene guanidine and polyhexamethylene biguanide respectively. The concentration was adjusted to 2000mg / L. It can be clearly seen from the above table that the bactericidal effect of the compound disinfectant is much better than that of the single component. At the same time, in terms of expanding the antibacterial spectrum, Candida albicans, which is highly resistant to guanidine disinfectants, also has a good ki...
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