Compound guanidine disinfectant and preparation method of compound guanidine disinfectant

A compound guanidine and disinfectant technology, applied in the field of compound guanidine disinfectant and its preparation, can solve the problems of unfavorable wound coating, unfavorable wound healing, inconvenient use and the like, and achieve good synergistic gain and strong adsorption. Killing effect, easy to operate effect

Inactive Publication Date: 2015-11-18
SHANGHAI YUKING NEW MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both iodine and chlorhexidine have poor water solubility. This patent dissolves iodine through potassium iodide and heats to 50°C to dissolve chlorhexidine acetate. However, the instability of iodine and chlorhexidine in aqueous solution is not clearly resolved in this patent. The problem
At the same time, 12%-15% polyvinyl alcohol is used as a film-forming agent, which makes the disinfectant solution very dense, which is not conducive to coat

Method used

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  • Compound guanidine disinfectant and preparation method of compound guanidine disinfectant
  • Compound guanidine disinfectant and preparation method of compound guanidine disinfectant
  • Compound guanidine disinfectant and preparation method of compound guanidine disinfectant

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0042] Example 1-4

[0043] Prepare compound guanidine disinfectant according to the components and contents shown in Table 1 below:

[0044] Table 1

[0045]

[0046] The preparation method of the compound guanidine disinfectant includes the following steps:

[0047] Step 1. Add the guanidine disinfectant to the surfactant according to the content of the component, and stir until it is completely dissolved;

[0048] Step 2. Add the high molecular weight film-forming agent, low molecular weight chitosan, and high molecular weight chitosan to 50%-60% of the required total water volume in water. After completely dissolved, add penetrant and skin care agent in sequence, and mix and stir evenly ;

[0049] Step 3. Stir the solution obtained in step 2 into the solution of step 1 while stirring, add the remaining water, and adjust the pH value to 7.0-7.5 with a pH regulator.

[0050] All the above-mentioned steps are carried out at room temperature to obtain the compound guanidine disinfectant ...

Example Embodiment

[0051] Example 5, stability test

[0052] The compound guanidine disinfectant provided in the above examples is tested according to the "Technical Specification for Disinfection" 2002 edition and the "Guanidine Disinfectant Hygiene Standard" to test the stability of the compound disinfectant: store at 37°C for 3 months , Test the effective content of its active ingredients polyhexamethylene biguanide and chlorhexidine acetate or chlorhexidine glucose. The test results are shown in Table 2.

[0053] Table 2 Stability test results of polyhexamethylene biguanide and chlorhexidine acetate or chlorhexidine glucose in compound guanidine disinfectants

[0054]

[0055] It can be seen from Table 2 that the disinfectant prepared according to the above-mentioned embodiment ratio and preparation method has been subjected to the accelerated stability test in the disinfection technical specifications, and its effective ingredients are polyhexamethylene biguanide and chlorhexidine acetate or chlo...

Example Embodiment

[0056] Example 6. Comparison of disinfection effect with single factor guanidine

[0057] Table 3 shows the disinfection effect comparison between the compound guanidine disinfectant of the present invention and the other two single-factor guanidine disinfectants, polyhexamethylene guanidine and polyhexamethylene biguanide.

[0058] table 3

[0059]

[0060] In Table 3, the compound is the disinfectant of the present invention, using the compound of polyhexamethylene biguanide and polyhexamethylene guanidine, and single guanidine and biguanide refer to polyhexamethylene guanidine and polyhexamethylene biguanide, respectively. The concentration is adjusted to 2000mg / L. It can be clearly seen from the above table that the bactericidal effect of compound disinfectants is much better than that of single ingredients. At the same time, in terms of expanding the antibacterial spectrum, Candida albicans, which is highly resistant to guanidine disinfectants, also has a good killing effect. ...

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Abstract

The invention provides a compound guanidine disinfectant, which comprises the following ingredients in percentage by weight: 0.5 to 4.0 percent of guanidine disinfectants, 0.05 to 0.2 percent of low-molecular-weight chitosan, 0.5 to 2.5 percent of high-molecular-weight chitosan, 0.1 to 0.5 percent of Chinese herbal medicine extracts, 0.1 to 1.0 percent of surfactants, 0.1 to 1.0 percent of penetrants, 0.1 to 0.5 percent of skin protectants, 0.1 to 0.5 percent of macromolecule film forming agents and the balance water; and the pH value of the compound guanidine disinfectant is regulated to 7.0 to 7.5 by pH regulating agents. Through the proportional combination of all the ingredients of the compound guanidine disinfectant, a good synergistic effect is achieved; and good sterilization and antibiosis capability is realized on bacterial reproductive bodies, fungi and partial viruses. The invention also provides a preparation method of the compound guanidine disinfectant. The compound disinfectant has the advantages that the preparation process is simple; the operation is convenient; the production cost is low; the scale production is convenient; meanwhile, the property of the disinfectant is stable; and the compound disinfectant is safe and nontoxic and can be easily stored.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a compound guanidine disinfectant for wound disinfection, hemostasis and healing and a preparation method thereof. Background technique [0002] In people's daily home, outdoor, entertainment, and work life, it is inevitable that there will be skin damage and trauma such as abrasions and cuts caused by accidents. The conventional treatment method is to use disinfectants such as alcohol, iodine, and iodophor to sterilize, and then use sterile gauze to bandage and fix the wound. However, this kind of disinfectant is very irritating to the wound, and only has the effect of disinfection and sterilization, and has no effect on the hemostasis and healing of some wounds and wounds. After the disinfection is completed, the wound or wound still needs to be bandaged, otherwise it is easy to cause wound Secondary infection prolongs healing time. Conventional wound dressings use gauze or band-aids, which ...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K47/36A61K9/70A61P17/02A61P31/02A61P31/04A61K31/785A61K31/155A61K31/722
Inventor 王宇朱广东熊俊超陈占
Owner SHANGHAI YUKING NEW MATERIAL TECH
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