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Bacterial cellulose/chitosan composite gel and preparation thereof, and application of composite gel in body surface wound surface healing

A technology of bacterial cellulose and composite gel, which is applied in antibacterial drugs, liquid delivery, drug combination, etc., can solve the problems of unfavorable wound dressing application, no antimicrobial and antibacterial activity, and inability to prevent and treat wound infection, so as to cut off radioactive contamination substances, avoiding drug resistance and multiple infections, and improving mechanical properties

Active Publication Date: 2013-12-25
江西佑创销售有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bacterial cellulose itself has no antimicrobial and antibacterial activity, and it cannot prevent wound infection by itself, which is unfavorable for its application in wound dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Stir the thickener carbomer powder with pure water at 80°C for 1.5h to make a solution with a mass fraction of 0.45%; mix chitosan powder with a molecular weight of 5000 and a deacetylation degree of 90% with pure water at 70 Stir at ℃ for 2.5h to make a chitosan solution with a mass fraction of 3.5%; Chitosan solution, carbomer solution, didecyldimethylammonium bromide and bacterial cellulose powder with a molecular weight of 80,000 were mixed evenly under stirring, and then slowly added dropwise triethanolamine with a mass percentage of 0.5% to adjust the pH value to 8.0; after standing at room temperature for 2 hours, vacuum defoaming is the finished product. Sterilized by Co60 after dispensing with tubes. 10g / bottle of the finished product is subpackaged with hoses and sterilized by Co60. Squeeze 15g / bottle of the finished product and apply it to the affected part of the skin contusion.

Embodiment 2

[0039] Stir the thickener carbomer powder with pure water at 70°C for 2 hours to make a solution with a mass fraction of 0.35%; stir chitosan with a molecular weight of 7500 and a deacetylation degree of 95% with pure water at 80°C 3h, make a chitosan solution with a mass fraction of 3%; then press the mass ratio of chitosan, bacterial cellulose, didecyldimethylammonium bromide and carbomer to be 1:0.08:0.08:0.003, Chitosan solution, carbomer solution, double-chain quaternary ammonium salt and bacterial cellulose fibrids with a molecular weight of 80,000 were mixed evenly under stirring, and then 0.5% by mass of 2-amino-2-formazan was slowly added dropwise. Base-1-propanol, adjust the pH value to 7.5; stand at room temperature for 8 hours for defoaming to obtain the finished product. Sterilized by Co60 after dispensing with tubes. Squeeze and coat 15g / piece of the finished product on the skin burn affected area.

Embodiment 3

[0041]It is 0.50% solution that thickener polyethylene glycol dimethyl benzaldehyde is made mass fraction overnight with pure water; The chitosan powder that molecular weight is 7000, deacetylation degree is 93% is with pure water Stir at 70°C for 2.5h to make a shell and make a chitosan solution with a mass fraction of 4%; : 0.04: 0.07: 0.004, mix chitosan solution, polyethylene glycol solution with benzaldehyde groups at both ends, double-chain quaternary ammonium salt and bacterial cellulose powder with a molecular weight of 90000 under stirring; then slowly Add 0.5% triisopropanolamine dropwise to adjust the pH value to 8.5; leave it standing at room temperature for 2.5 hours and vacuum defoam to obtain the finished product. Sterilized by Co60 after dispensing with tubes. Squeeze and coat 20g / bottle of the finished product on the affected part of the skin burn.

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PUM

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Abstract

The invention relates to a bacterial cellulose / chitosan composite gel and preparation thereof, and application of the composite gel in body surface wound surface healing. The composite gel is composed of a chitosan solution, bacterial cellulose, an antimicrobial agent, a thickener solution and a neutralization agent. The invention also relates to application of the bacterial cellulose / chitosan composite gel in preparing body surface wound surface healing medicines. The preparation method comprises the following steps: uniformly mixing the chitosan solution, thickener solution, bacterial cellulose and antimicrobial agent, adding the neutralization agent to regulate the pH value to 6.0-9.0, and standing for deforming. The composite gel provided by the invention has favorable film-forming action, and performs the functions of isolating the wound surface and protecting the wound; and the bacterial cellulose / chitosan has the advantages of simple preparation process and easy technical control, and is convenient for industrial production.

Description

technical field [0001] The invention belongs to the field of composite gel and its preparation and application, in particular to a bacterial cellulose chitosan composite gel and its preparation and application of body surface wound healing. Background technique [0002] Body surface wounds (wounds) are a common physiological phenomenon. There are many kinds of wounds in daily life, such as mechanical injuries caused by friction, bullets, knives, bites and surgery, as well as burns caused by heat, chemicals, electricity and radiation. Chronic wounds such as bed sores and ulcers often appear in the elderly, which are difficult to treat and often seriously affect the physical and mental health and quality of life of patients. Wounds within a certain size range can be treated with wound dressings. This method can avoid traditional autologous skin transplantation "healing wounds with wounds", can reduce patients' pain, and is economical and practical, so it is an ideal treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K9/06A61P17/02A61P31/04A61K31/717
Inventor 沈新元杨昌顺
Owner 江西佑创销售有限公司
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