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Degradable skin tissue engineering bracket material and preparation method thereof

A technology for skin tissue engineering and scaffold materials, which is applied in the field of preparing skin tissue engineering scaffolds and can solve the problems of poor hygroscopicity and water permeability of polymer films.

Inactive Publication Date: 2009-08-19
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the poor hygroscopicity and water permeability of polymer films applied to tissue engineering skin at present, we proposed to prepare a blend film based on konjac glucomannan

Method used

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  • Degradable skin tissue engineering bracket material and preparation method thereof
  • Degradable skin tissue engineering bracket material and preparation method thereof
  • Degradable skin tissue engineering bracket material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Mix 0.1wt% glycerol solution of 0.1wt% type II collagen with 0.1wt% protonated chitosan solution, add konjac glucomannan powder to prepare 0.1wt% solution and stir until gelatinous , put it in a vacuum defoaming device for defoaming, take it out and let it stand still, pour it into a mold to form a film, and dry it at a constant temperature to remove the film.

Embodiment 2

[0026] Example 2 Mix 10wt% glycerol solution of 10wt% type II collagen with 10wt% protonated chitosan solution, add konjac glucomannan powder to prepare a 25wt% solution, stir until gelatinous, and place in a vacuum The defoaming device is used for defoaming. After taking it out and standing still, it is poured into a mold to form a film, and the film is dried and peeled off at a constant temperature.

Embodiment 3

[0027] Example 3 Mix 0.1wt% type II collagen 10wt% glycerol solution with 0.1wt% chitosan protonated solution, add konjac glucomannan powder to prepare 0.1wt% solution and stir until gelatinous, Put it in a vacuum defoaming device for defoaming, take it out and let it stand still, pour it into a mold to form a film, dry it at a constant temperature and peel off the film.

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PUM

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Abstract

The invention discloses a material in the field of biomedical tissue engineering, in particular a method for preparing a skin tissue engineering bracket by adopting polysaccharide substances in nature and utilizing a blending method. The method comprises the following steps that: a glycerol solution of II-type collagen and a protonation solution of chitosan are first prepared respectively, evenly blended, added with quantitative konjak glucomannan fine powder and continually stirred to be sol; a gel sample is put into a vacuum foam-removing device for foam removal, taken out, kept to stand and poured into a die; and a film is formed, dried at a constant temperature and then taken off. The material is a polymer material applied to skin or nerve repair, and the prepared film is ideal in mechanical properties, degradation performance, water absorption and steam transmission coefficient. The invention relates to a degradable skin tissue engineering bracket material and a preparation method thereof.

Description

technical field [0001] The invention relates to a material in the field of biomedical tissue engineering, in particular to a method for preparing a scaffold for skin tissue engineering by using a blending method using natural polysaccharide substances. Background technique [0002] Tissue-engineered skin is the earliest and most mature field in tissue engineering. The earliest research started from natural materials, and later it was the compounding of natural materials and synthetic materials, until now it is the hybridization, cross-linking, Mutual transmission network, and the most recent artificial synthetic natural materials - biomimetic materials. However, there are still some defects in the current materials. In order to meet the construction of artificial organs in vitro, the biocompatibility, physical and chemical properties, in vivo degradation rate, sustained release performance of biodegradable materials, and scaffold preparation methods and processes that meet t...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/20A61L27/60
Inventor 陈庆华杨喜昆李娜娜
Owner KUNMING UNIV OF SCI & TECH
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