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Preparation method of self-repairing bionic hydrogel with toughness and adhesion

An adhesive and hydrogel technology, applied in the field of biomedical engineering, can solve the problems of poor self-healing effect and poor biocompatibility, and achieve the effects of high mechanical strength, good water absorption and excellent adhesion

Active Publication Date: 2021-03-05
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of preparation method of poly(dopamine)-agar / N-hydroxyethylacrylamide double network hydrogel with super self-healing performance, solve the problem faced in the use process of bionic hydrogel patch at present Poor self-healing effect and poor biocompatibility

Method used

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  • Preparation method of self-repairing bionic hydrogel with toughness and adhesion
  • Preparation method of self-repairing bionic hydrogel with toughness and adhesion
  • Preparation method of self-repairing bionic hydrogel with toughness and adhesion

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Embodiment 1

[0031] First, 16.5 wt% of agar powder was added into 1 mL of deionized water, and stirred at 98° C. and 1000 r / min at a high temperature for 0.5 h. Add 15 mg of dopamine hydrochloride and make it completely dissolved in the above mixture, and perform ultrasonic treatment after stirring for 30 min. Then 30wt% N-hydroxyethylacrylamide (HEAA) and photoinitiator 2-hydroxyl-4-(2-hydroxyethoxy)-2-methylpropiophenone (1wt% HEAA) were added dropwise to the above mixture, After stirring and reacting for 120 h, ensure the sufficient and uniform mixing of the three polymers to obtain a uniformly mixed primary gel solution and seal it for storage. Subsequently, the pregel solution was poured into a mold, and photopolymerization was carried out in a dark box under UV light (wavelength 365 nm, power 10 w) for 0.5 h. Obtain the multifunctional biomimetic hydrogel.

Embodiment 2

[0033] First, 20 wt% of agar powder was added to 1 mL of deionized water, and stirred at 98° C. and 1000 r / min at a high temperature for 0.5 h. Add 15 mg of dopamine hydrochloride and make it completely dissolved in the above mixture, and perform ultrasonic treatment after stirring for 30 min. Then 45wt% N-hydroxyethylacrylamide (HEAA) and photoinitiator 2-hydroxyl-4-(2-hydroxyethoxy)-2-methyl propiophenone (1wt% HEAA) were added dropwise in the above mixture, After stirring and reacting for 120 h, ensure the sufficient and uniform mixing of the three polymers to obtain a uniformly mixed primary gel solution and seal it for storage. Subsequently, the pregel solution was poured into a mold, and photopolymerization was carried out in a dark box under UV light (wavelength 365 nm, power 10 w) for 0.5 h. Obtain the multifunctional biomimetic hydrogel.

[0034] figure 1 It is an optical photograph of the polymerization process of the agar-dopamine-p(HEAA) mixed double network hyd...

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Abstract

The invention discloses a preparation method of a self-repairing bionic hydrogel with both toughness and adhesion. The preparation method comprises the following steps of: dissolving agar powder in water, and heating and stirring the mixture to highly swell the mixture to obtain a uniform agar sol solution; dissolving a dopamine hydrochloride monomer into the solution, performing ultrasonic uniform dispersing; and dropwise adding a buffer solution to control the pH value of the solution so as to make the dopamine hydrochloride monomer polymerized into a short-chain network; after performing treatment, mixing an obtained product with an N-hydroxyethyl acrylamide monomer, and meanwhile, adding a photoinitiator to obtain a pre-gel solution; and putting the pre-gel solution into a mold, and carrying out an ultraviolet irradiation reaction. The multifunctional bionic double-network hydrogel prepared by the preparation method of the invention has the advantages of high mechanical strength, strong adhesion, strong self-healing capability, low cost, mild reaction and good biocompatibility, and has potential application value in the fields of biomedicine and tissue engineering and drug delivery systems.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and relates to a preparation method of a self-repairing bionic hydrogel having both toughness and adhesion. Background technique [0002] Hydrogels are a class of soft materials with a three-dimensional polymer network formed by hydrophilic polymers, which can absorb large amounts of water while maintaining their shape. Hydrogel has biodegradability and excellent biocompatibility, and can simulate the three-dimensional microenvironment of extracellular matrix to regulate cell behavior and tissue function. In recent years, hydrogels have received continuous attention because of their broad application prospects in the field of biomedical engineering. Many hydrogel formulations have been successfully applied in many directions, such as functional drug controlled release systems, flexible electrodes, sensors and wearable devices, etc. [0003] Wound healing requires a humid environm...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/28C08L79/04C08L5/12C08F251/00C08F220/58C08F2/48A61L26/00
CPCC08J3/075C08J3/28C08F251/00C08F2/48A61L26/008A61L26/0052A61L26/0061C08J2305/12C08J2479/04C08L33/24C08L5/12C08L79/04C08F220/58
Inventor 冯章启李瑞金飞李通杜丽娟
Owner NANJING UNIV OF SCI & TECH
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