Polypeptide molecular derivative with mineralizing function for biomedicine tissue engineering and application thereof

A tissue engineering and biomedical technology, applied in the field of biomedical materials, can solve the problem of lack of biological materials, and achieve the effect of good biological activity
CN110172081AActive Publication Date: 2019-08-27NANJING JIUZHENWEI MEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING JIUZHENWEI MEDICAL TECH CO LTD
Publication Date
2019-08-27

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Abstract

The invention provides a polypeptide molecular derivative with a mineralizing function for biomedicine tissue engineering and application thereof, and belongs to the technical field of biomedical materials. The polypeptide molecular derivative has a molecular structure general formula of X-X-Cys-Cys-Cys-Cys-Y-Y-Z-W-NH2; wherein X is Asn or glucoylated asparagine; Y is Arg or Lys; Z is Glu or Asp;and W is phosphorylated serine or phosphorylated threonine. The polypeptide molecular derivative provided by the invention can induce the oriented growth of apatite crystals to form a biological material with a structure similar to an organism sclerous tissues microstructure; can be automatically assembled to form 3D (three-dimensional) nanometer hydrogel under the induction of calcium chloride, so as to be applied to a scaffold material for bone tissue engineering or to 3D in-situ cultivation of cells; can be compounded with collagenous fiber to induce the mineralization of the collagenous fiber, so as to be applied to study on bone tissue regeneration, as well as to induce the mineralizing regeneration and repair of cementum and dentin.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a polypeptide molecular derivative with mineralization function. Background technique

[0002] Once the hard tissue of the body is damaged, it is difficult to achieve self-healing repair, so the regeneration and repair of hard tissue is one of the important research topics in clinical medicine and stomatology. One of the keys to achieve human hard tissue regeneration is to induce the formation of calcium phosphate by growth factors or their biomimetic analogs. The regeneration of periodontal tissue in stomatology is more complicated. One of the keys to rebuilding a functional periodontal complex is to attach the fibrous connective tissue of the periodontal ligament to the mineralized layer on the surface of the cementum and alveolar bone. Among them, cementum is an avascular mineralized hard tissue attached to the surface of the root, and the fibrous co...

Claims

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