Biomimetic full-molded three-phase structure artificial ligament and preparation method thereof

An artificial ligament and fully formed technology, applied in ligaments, medical science, muscles, etc., can solve the problems of mismatching growth rate of new tissue during ligament degradation time, insufficient mechanical properties, etc., and achieve the effect of oriented growth and dense weaving structure

Active Publication Date: 2019-07-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on degradable artificial ligaments focuses on tissue engineering artificial ligaments. The bionic design is mainly based on bionic materials. The promotion of tissue regeneration still needs to rely on bionic materials such as acellular matrix, collagen and growth factors, and there are insufficient mechanical properties, and the degradation time of ligaments is limited. The growth rate of new tissue does not match, etc.
Only using structural bionics to promote good tissue regeneration, and high-strength degradable artificial ligaments have not been reported

Method used

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  • Biomimetic full-molded three-phase structure artificial ligament and preparation method thereof
  • Biomimetic full-molded three-phase structure artificial ligament and preparation method thereof
  • Biomimetic full-molded three-phase structure artificial ligament and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the bionic fully formed three-phase structure artificial ligament shown in Figure 1 is:

[0035] The first step is to determine the yarn and ligament structure parameters. Yarn A, yarn B, and yarn C are PPDO, PGCL, and PGLA respectively. The diameter of a single yarn is 0.3mm, and the complete degradation time is 11 months, 9 months, and 4 months, respectively. The proportions are 40%, 40% and 20% in turn. The diameter of the bionic fully formed three-phase structure artificial ligament is 5.7mm, the diameter of the three-phase small-diameter braided bundle of the nuclear layer is 1.8mm, the length of the bone tunnel braided section is 3mm, and the joint cavity fiber The beam segment is 2.5mm long.

[0036] The second step is the weaving of three-phase small diameter braided bundles. Install the spindles on a 24-spindle braiding machine according to a specific loading method, without adding an inner tube, and weave directly so that the two en...

Embodiment 2

[0041] The preparation method of the bionic fully formed three-phase structure artificial ligament shown in Figure 1 is:

[0042]The first step is to determine the yarn and ligament structure parameters. Yarn A, yarn B, and yarn C are P4HB, PPDO, and PGCL respectively. The diameter of a single yarn is 0.3mm, and the complete degradation time is 15 months, 11 months, and 6 months. The proportions are 50%, 37.5% and 12.5% ​​in turn. The diameter of the bionic fully formed three-phase structure artificial ligament is 6.2 mm, the diameter of the three-phase small-diameter braided bundle of the nuclear layer is 2 mm, the length of the bone tunnel braided section is 3 mm, and the joint cavity fiber bundle The segment length is 2.5mm.

[0043] The second step is the weaving of three-phase small diameter braided bundles. Install the spindles on a 24-spindle braiding machine according to a specific loading method, without adding an inner tube, and weave directly so that the two ends ...

Embodiment 3

[0048] The preparation method of the bionic fully formed three-phase structure artificial ligament shown in Fig. 1 is:

[0049] The first step is to determine the yarn and ligament structure parameters. Yarn A, yarn B, and yarn C are P4HB, PPDO, and PGCL respectively. The diameter of a single yarn is 0.3mm, and the complete degradation time is 15 months, 11 months, and 6 months. The proportions are 60%, 30% and 10% in turn. The diameter of the bionic fully formed three-phase structure artificial ligament is 7.1 mm, the diameter of the three-phase small-diameter braided bundle of the nuclear layer is 2.3 mm, the length of the bone tunnel braided segment is 3 mm, and the joint cavity fiber The beam segment is 2.5mm long.

[0050] The second step is the weaving of three-phase small diameter braided bundles. Install the spindles on a 24-spindle braiding machine according to a specific loading method, without adding an inner tube, and weave directly so that the two ends are bone ...

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Abstract

The present invention provides a biomimetic full-molded three-phase structure artificial ligament and a preparation method thereof. The biomimetic full-molded three-phase structure artificial ligamentis characterized by comprising a three-phase structure and a core-shell tubular structure; the three-phase structure is two end part bone tunnel woven sections and a joint cavity-fiber bundle section; and the core-shell tubular structure can integrally prepare a shell-layer three-phase tubular woven material and at the same time introduces three-phase small-diameter woven bundles as a core layerinside. Yarns used for weaving have different degradation cycles. The structure of the artificial ligament can be designed by changing a yarn ratio and a spindling method, so that the artificial ligament has good mechanical properties, achieves cycle-controlled gradient degradation, produces three-dimensional channels beneficial to growth of ligament cells and achieves a purpose of matching a degradation rate with a regeneration rate of self tissues. After the weaving is completed, samples are washed, the washed samples are heat-shaped, and finally the biomimetic full-molded three-phase structure artificial ligament is prepared.

Description

technical field [0001] The invention relates to a bionic fully formed three-phase structure artificial ligament for treating anterior cruciate ligament injury and a preparation method thereof, belonging to the technical field of biomedical textile preparation. Background technique [0002] The anterior cruciate ligament (ACL) is an important ligament structure in the knee joint. Its main function is to control the rotation of the knee joint, prevent the posterior displacement of the femur or excessive forward displacement of the tibia, maintain the stability of the knee joint, and assist in controlling the rotation and lateral movement of the knee joint. ACL injuries are very common during sports and everyday activities. Anterior cruciate ligament injury can reduce the stability of the knee joint, seriously affecting its movement function. The anterior cruciate ligament is a dense connective tissue with low degree of vascularization and is difficult to heal endogenously. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/08
CPCA61F2/08A61F2240/001A61F2210/0004A61F2230/0063
Inventor 林婧黄云帆谢晓静劳继红王璐
Owner DONGHUA UNIV
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