The discloses a high-performance thermosetting polyester powder coating which comprises the raw materials: pure polyester resin, fluorinated polyester resin, epoxy resin, terminal carboxyl nitrile rubber, N,N,N,N'-tetra(2-ethoxyl) adipamide, tetramethoxyl methyl glycoluril, triglycidyl isocyanurate, amino resin, phenyl-2-imidazoline, 2-methylimidazole, chitosan, sodium lignin sulfonate, starch, polyethylene, polyvinyl butyral, nano titanium dioxide, aluminium oxide, zinc borate, mica iron oxide, montmorillonite, nanosilver, activated carbon powder, lanthanum oxide and auxiliaries. The high-performance thermosetting polyester powder coating disclosed by the invention is good in water resistance, oil resistance and heat resistance and excellent in weather resistance, acid and alkaline corrosion resistance and pollution resistance, and is good in comprehensive performance and long in service life if being used as an outdoor coating.