60 results about "2-Imidazoline" patented technology

PCT No. PCT / US97 / 20803 Sec. 371 Date Aug. 9, 1999 Sec. 102(e) Date Aug. 9, 1999 PCT Filed Nov. 21, 1997 PCT Pub. No. WO98 / 23611 PCT Pub. Date Jun. 4, 1998This invention relateds to compounds of formula I, (2-imidazolinylamino)benzoxazoles. The compounds have been found to be alpha-2 adrenocepto agonists and are useful for treatment of disorders modulated by alpha-2 adrenoceptors.

This invention involves compounds having the following structure:wherein:a) R1 is hydrogen; or alkyl; bond (a) is a single or a double bond;b) R2 and R3 are each independently selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo;c) R4, R5 and R6 are each independently selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino; halo; and 2-imidazolinylamino; and wherein one and only one of R4, R5 and R6 is 2-imidazolinylamino;d) R7 is selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo;e) the compound is not 4-(2-imidazolinylamino)indole;enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.

This invention provides pharmacologically active compounds having neurological and other bio-active capability. These active compounds comprise the derivatives of guanidino, aminoguanidino, 2-imadazolino, 2-hydrazinoimidazolino or 2-guanidinobenzimidazolino groups.

The invention discloses an environment-friendly steel surface anti-rust agent and a preparation method thereof. The preparation method comprises the following steps: mixing polyethylene wax, liquefied paraffin, methyl-2-imidazoline and deionized water according to weight parts, stirring and heating to 120-130 DEG C, insulating for 1 hour, and cooling to 40-50 DEG C; adding 3-aminopropyltrimethoxysilane, epoxy rice bran oil, amino trimethylene phosphonic acid, isopropanolamine, sodium gluconate, benzotriazole, a surfactant, carboxymethyl cellulose, a thickening agent and sodium lauryl sulfate, and stirring until the components are completely dissolved. The anti-rust agent uses water as a dispersing medium, has excellent environment-friendly performance, is non-combustible and unexplosive, does not have pollution, and does not have toxicity and risk on human bodies. The anti-rust agent has an excellent construction performance, cannot corrode metal in the using process, is simple and convenient to apply, and can be used for effectively protecting metal from corrosion by soaking, spraying, coating and other modes. The anti-rust period of the anti-rust agent can be 10-12 months in a normal environment.