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Preparation and application of near-infrared-response photodynamic optothermal treatment nano-composite material

A nanocomposite material and photothermal therapy technology are applied in the field of preparation of photodynamic photothermal therapy nanocomposite materials, which can solve the problem of general photothermal conversion efficiency and free radical generation rate, affecting the tumor treatment effect of nanocomposite materials, raw materials and preparation. The problem of complex methods, etc., achieves the effect of high free radical generation rate, low cost and large load.

Active Publication Date: 2018-12-07
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, for example, the nanocomposite material provided by the patent No. 2014108269533 "a nanocomposite material applied to photodynamic therapy and its preparation method" has complex raw materials and preparation methods, and its absorption strength in the near-infrared region The photothermal conversion efficiency and free radical generation rate are not high, which affects the tumor treatment effect of nanocomposites

Method used

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  • Preparation and application of near-infrared-response photodynamic optothermal treatment nano-composite material
  • Preparation and application of near-infrared-response photodynamic optothermal treatment nano-composite material
  • Preparation and application of near-infrared-response photodynamic optothermal treatment nano-composite material

Examples

Experimental program
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Effect test

Embodiment 1

[0041] The preparation method of the photodynamic photothermal therapy nano-composite material with near-infrared response provided in this example has the following steps.

[0042] (1) Take 0.24g of polyacrylic acid with a concentration of 50% and add it to 4.5mL of ammonia water with a concentration of 25%-28%, stir and mix slowly to obtain the mixed solution I;

[0043] (2) Drop the mixed solution I into 90mL absolute ethanol, stir at room temperature for 30min; slowly add 1.8mL tetraethoxysilane dropwise therein, and stir at room temperature for 10h; then centrifuge and wash with absolute ethanol for 3 times, and then Ultrasonic centrifugal dispersion in pure water, freeze-dried to obtain nano-silica carrier;

[0044] (3) Add 20 mg of nano-silica carrier to 15 mL of ultrapure water for ultrasonic dispersion, and then add 200 μL of CuCl with a concentration of 0.1M 2 2H 2 O solution, stirred at room temperature for 6 hours, and dispersed in ultrapure water by ultrasonic c...

Embodiment 2

[0048] The preparation method of the near-infrared responsive photodynamic photothermal therapy nanocomposite provided in this example is basically the same as in Example 1, except that the myristyl alcohol in step (5) is replaced by lauric acid.

Embodiment 3

[0050] The preparation method of the photodynamic photothermal therapy nano-composite material with near-infrared response provided in this example has the following steps.

[0051] (1) Take 2.8mL of absolute ethanol, 0.05g of diethanolamine, and 2.6mL of cetyltrimethylammonium chloride aqueous solution with a concentration of 25wt%, add it to 16mL of ultrapure water and mix; stir at 60°C for 6h , to get the mixture II;

[0052] (2) Add 1.75mL tetraethoxysilane and 0.15mL 3-mercaptopropyltrimethoxysilane to the mixture II, stir at room temperature for 3h; then add 1.2mL dimethyldiethoxysilane, stir at room temperature for 20h , to obtain the mixed solution III;

[0053] (3) Centrifuge the mixed solution III with absolute ethanol for 3 times, then add 7.5mL of concentrated hydrochloric acid and 60mL of absolute ethanol, stir at 60°C for 24 hours; finally wash with absolute ethanol for 3 times, and centrifuge in ultrapure water Disperse and freeze-dry to obtain nano-silica car...

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Abstract

The invention discloses preparation of a near-infrared-response photodynamic optothermal treatment nano-composite material. The preparation comprises the following steps: dispersing a nano-silicon dioxide carrier into a solvent, adding CuCl2.2H2O solution, stirring, and carrying out dispersion in ultrapure water; adding an Na2S.9H2O solution, stirring at room temperature, then stirring at 90 DEG C, and carrying out dispersion in ultrapure water, so as to obtain suspension liquid; and adding a temperature-sensitive photodynamic reagent into the suspension liquid, dissolving a phase-conversion material into absolute ethyl alcohol, adding absolute ethyl alcohol into the suspension liquid, stirring at the room temperature for 4-8 hours, carrying out centrifugal washing, and drying, so as to obtain the finished nano-composite material, wherein the solvent is ultrapure water or absolute ethyl alcohol, the temperature-sensitive photodynamic reagent is 2,2-aza-bis(2-imidazoline) dihydrochloride and the phase-conversion material is tetradecyl alcohol or lauric acid. When the nano-composite material is used, the infrared induced excitation temperature is 37-44 DEG C, and the time is 2-6 hours. The nano-composite material is good in biocompatibility, relatively strong in absorptivity in a near infrared region, relatively high in photo-thermal conversion rate and free radical generation rate, high in loading capacity, has a good treatment effect and does not have side reaction; and the process is simple, low in cost and wide in application range.

Description

technical field [0001] The invention belongs to the field of photodynamic therapy agents, in particular to the preparation and application of a near-infrared responsive photodynamic photothermal therapy nanocomposite material. Background technique [0002] Photodynamic therapy (PDT) is a new approach to treat tumor diseases with photosensitizing drugs and laser activation. It uses a specific wavelength to irradiate the tumor site to activate the photosensitive drug selectively gathered in the tumor tissue, triggering a photochemical reaction to destroy the tumor. When the photosensitive drug in PDT is activated, it will transfer energy to the surrounding oxygen to generate a highly active singlet oxygen. Singlet oxygen can oxidize with nearby biomacromolecules to produce cytotoxicity and kill tumor cells. [0003] The generation of singlet oxygen in traditional PDT is heavily dependent on oxygen, which is a major obstacle for the clinical application of PDT. Because most ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057A61P35/00
Inventor 刘湘梅张京徽韩艺蕃刘淑娟赵强黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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