Preparation and application of near-infrared-response photodynamic optothermal treatment nano-composite material

A nanocomposite material and photothermal therapy technology are applied in the field of preparation of photodynamic photothermal therapy nanocomposite materials, which can solve the problem of general photothermal conversion efficiency and free radical generation rate, affecting the tumor treatment effect of nanocomposite materials, raw materials and preparation. The problem of complex methods, etc., achieves the effect of high free radical generation rate, low cost and large load.
CN108939073AActive Publication Date: 2018-12-07NANJING UNIV OF POSTS & TELECOMM
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING UNIV OF POSTS & TELECOMM
Publication Date
2018-12-07

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Abstract

The invention discloses preparation of a near-infrared-response photodynamic optothermal treatment nano-composite material. The preparation comprises the following steps: dispersing a nano-silicon dioxide carrier into a solvent, adding CuCl2.2H2O solution, stirring, and carrying out dispersion in ultrapure water; adding an Na2S.9H2O solution, stirring at room temperature, then stirring at 90 DEG C, and carrying out dispersion in ultrapure water, so as to obtain suspension liquid; and adding a temperature-sensitive photodynamic reagent into the suspension liquid, dissolving a phase-conversion material into absolute ethyl alcohol, adding absolute ethyl alcohol into the suspension liquid, stirring at the room temperature for 4-8 hours, carrying out centrifugal washing, and drying, so as to obtain the finished nano-composite material, wherein the solvent is ultrapure water or absolute ethyl alcohol, the temperature-sensitive photodynamic reagent is 2,2-aza-bis(2-imidazoline) dihydrochloride and the phase-conversion material is tetradecyl alcohol or lauric acid. When the nano-composite material is used, the infrared induced excitation temperature is 37-44 DEG C, and the time is 2-6 hours. The nano-composite material is good in biocompatibility, relatively strong in absorptivity in a near infrared region, relatively high in photo-thermal conversion rate and free radical generation rate, high in loading capacity, has a good treatment effect and does not have side reaction; and the process is simple, low in cost and wide in application range.
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Description

technical field

[0001] The invention belongs to the field of photodynamic therapy agents, in particular to the preparation and application of a near-infrared responsive photodynamic photothermal therapy nanocomposite material. Background technique

[0002] Photodynamic therapy (PDT) is a new approach to treat tumor diseases with photosensitizing drugs and laser activation. It uses a specific wavelength to irradiate the tumor site to activate the photosensitive drug selectively gathered in the tumor tissue, triggering a photochemical reaction to destroy the tumor. When the photosensitive drug in PDT is activated, it will transfer energy to the surrounding oxygen to generate a highly active singlet oxygen. Singlet oxygen can oxidize with nearby biomacromolecules to produce cytotoxicity and kill tumor cells.

[0003] The generation of singlet oxygen in traditional PDT is heavily dependent on oxygen, which is a major obstacle for the clinical application of PDT. Because most ...

Claims

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