Application of methyl-2-imidazoline as pH value and Fe<3+> dual-functional fluorescent probe and fluorescent probe prepared from methyl-2-imidazoline

A methyl imidazoline, fluorescent probe technology, applied in the application field of pH probe and metal ion recognition, can solve the problems of complex synthesis process, high toxicity, self-aggregation, etc., and achieves good selectivity, less toxic and side effects, and water solubility. high effect
CN107629786AInactive Publication Date: 2018-01-26UNIV OF JINAN
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF JINAN
Publication Date
2018-01-26
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention relates to the application field of a pH probe and metal ion recognition, in particular to an application of methyl-2-imidazoline as a pH value and Fe<3+> dual-functional fluorescent probe and the dual-functional fluorescent probe prepared from methyl-2-imidazoline and used for pH sensing and Fe<3+> detection. The fluorescent probe has the benefits as follows: the fluorescent substance methyl-2-imidazoline has small toxic or side effects, good selectivity and high sensitivity, is firstly found to have good fluorescence characteristics and is applied to the field of fluorescent probes. The synthesis mechanism of a fluorescent compound is manure, the fluorescent compound is low in cost and high in water solubility, and measurement of acidic pH (2.0-5.0) of a water solution as well as recognition and quantitative detection of Fe<3+> in the physiological environment can be realized.
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Description

technical field

[0001] The invention relates to the field of application of pH probes and metal ion recognition, in particular, to a small molecule 2-methylimidazoline without typical fluorescent groups as the pH value and Fe 3+ Application of bifunctional fluorescent probes. Background technique

[0002] It is well known that the change in fluorescence properties of some organic compounds with pH can be used to indicate changes in pH in the target medium. At present, fluorescent probes are mainly used in the fields of bioanalytical chemistry and cell biology. Abnormal pH changes will lead to cell dysfunction, especially when the intracellular pH is acidic, the weakening of the cells will cause their metabolism to slow down. Organ function is affected to some extent. Fluorescent probes can be used to monitor the dynamic distribution and regional changes of intracellular pH in real time by using a mild mode of operation to measure pH. Similarly, iron is one of the most ess...

Claims

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