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A bionic fully formed three-phase artificial ligament and its preparation method

An artificial ligament, fully formed technology, applied in ligament, medical science, prosthesis, etc., can solve the problems of mismatched growth rate of new tissue during ligament degradation time, insufficient mechanical properties, etc. Effect

Active Publication Date: 2021-12-10
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on degradable artificial ligaments focuses on tissue engineering artificial ligaments. The bionic design is mainly based on bionic materials. The promotion of tissue regeneration still needs to rely on bionic materials such as acellular matrix, collagen and growth factors, and there are insufficient mechanical properties, and the degradation time of ligaments is limited. The growth rate of new tissue does not match, etc.
Only using structural bionics to promote good tissue regeneration, and high-strength degradable artificial ligaments have not been reported

Method used

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  • A bionic fully formed three-phase artificial ligament and its preparation method
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  • A bionic fully formed three-phase artificial ligament and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the bionic fully formed three-phase structure artificial ligament shown in Figure 1 is:

[0035] The first step is to determine the yarn and ligament structure parameters. Yarn A, yarn B, and yarn C are PPDO, PGCL, and PGLA respectively. The diameter of a single yarn is 0.3mm, and the complete degradation time is 11 months, 9 months, and 4 months, respectively. The proportions are 40%, 40% and 20% in turn. The diameter of the bionic fully formed three-phase structure artificial ligament is 5.7mm, the diameter of the three-phase small-diameter braided bundle of the nuclear layer is 1.8mm, the length of the bone tunnel braided section is 3mm, and the joint cavity fiber The beam segment is 2.5mm long.

[0036] The second step is the weaving of three-phase small diameter braided bundles. Install the spindles on a 24-spindle braiding machine according to a specific loading method, without adding an inner tube, and weave directly so that the two en...

Embodiment 2

[0041] The preparation method of the bionic fully formed three-phase structure artificial ligament shown in Figure 1 is:

[0042]The first step is to determine the yarn and ligament structure parameters. Yarn A, yarn B, and yarn C are P4HB, PPDO, and PGCL respectively. The diameter of a single yarn is 0.3mm, and the complete degradation time is 15 months, 11 months, and 6 months. The proportions are 50%, 37.5% and 12.5% ​​in turn. The diameter of the bionic fully formed three-phase structure artificial ligament is 6.2 mm, the diameter of the three-phase small-diameter braided bundle of the nuclear layer is 2 mm, the length of the bone tunnel braided section is 3 mm, and the joint cavity fiber bundle The segment length is 2.5 mm.

[0043] The second step is the weaving of three-phase small diameter braided bundles. Install the spindles on a 24-spindle braiding machine according to a specific loading method, without adding an inner tube, and weave directly so that the two ends...

Embodiment 3

[0048] The preparation method of the bionic fully formed three-phase structure artificial ligament shown in Fig. 1 is:

[0049] The first step is to determine the yarn and ligament structure parameters. Yarn A, yarn B, and yarn C are P4HB, PPDO, and PGCL respectively. The diameter of a single yarn is 0.3mm, and the complete degradation time is 15 months, 11 months, and 6 months. The proportions are 60%, 30% and 10% in turn. The diameter of the bionic fully formed three-phase structure artificial ligament is 7.1 mm, the diameter of the three-phase small-diameter braided bundle of the nuclear layer is 2.3 mm, the length of the bone tunnel braided segment is 3 mm, and the joint cavity fiber The beam segment is 2.5mm long.

[0050] The second step is the weaving of three-phase small diameter braided bundles. Install the spindles on a 24-spindle braiding machine according to a specific loading method, without adding an inner tube, and weave directly so that the two ends are bone ...

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Abstract

The present invention provides a bionic fully formed three-phase structure artificial ligament and a preparation method thereof, which is characterized in that it has a three-phase, core-shell tubular structure, and the three-phase structure is two end bone tunnel braided sections and a joint Cavity fiber bundle segment; the core-shell tubular structure can introduce a three-phase small-diameter braided bundle as a core layer while integrally preparing the shell three-phase tubular braid. The yarns used for weaving have different degradation cycles, and the structure of the artificial ligament can be designed by changing the yarn ratio and spindle loading method, so that it has good mechanical properties and achieves cycle-controlled gradient degradation, which is conducive to the growth of ligament cells. The three-dimensional channel achieves the purpose of matching the degradation rate with the regeneration rate of its own tissue. After the weaving is completed, the sample is cleaned, heat-set and other post-processing, and finally a bionic fully formed three-phase structure artificial ligament is prepared.

Description

technical field [0001] The invention relates to a bionic fully formed three-phase structure artificial ligament for treating anterior cruciate ligament injury and a preparation method thereof, belonging to the technical field of biomedical textile preparation. Background technique [0002] The anterior cruciate ligament (ACL) is an important ligament structure in the knee joint. Its main function is to control the rotation of the knee joint, prevent the posterior displacement of the femur or excessive forward displacement of the tibia, maintain the stability of the knee joint, and assist in controlling the rotation and lateral movement of the knee joint. ACL injuries are very common during sports and everyday activities. Anterior cruciate ligament injury can reduce the stability of the knee joint, seriously affecting its movement function. The anterior cruciate ligament is a dense connective tissue with low degree of vascularization and is difficult to heal endogenously. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/08
CPCA61F2/08A61F2240/001A61F2210/0004A61F2230/0063
Inventor 林婧黄云帆谢晓静劳继红王璐
Owner DONGHUA UNIV
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