Preparation method of anisotropic structural color film for myocardial mechanical sensing

Abstract

The invention discloses a preparation method of an anisotropic structural color film for myocardial mechanical sensing, which comprises the following steps: a thermoplastic material with good biocompatibility and strong tensile property is selected to prepare a solution, the uniformly spin-coating of solution on a plasma-treated glass sheet is carried out, and heating is carried out to volatilize the solvent to obtain a cured flexible film substrate; a micron-sized groove structure template and an orderly-arranged nano-sized cylindrical structure template are utilized, a flexible film substrate is clamped between the two templates and put into a nano hot stamping instrument, and the anisotropic structural color film for myocardial mechanical sensing is obtained through a one-step method. The film is endowed with typical structural colors and characteristic reflection peaks, the arrangement mode of myocardial cells in vivo can be truly and effectively simulated, the change of the color of an upper-layer two-dimensional photonic crystal structure is shown along with jumping of the myocardial cells, then quantification is carried out according to the displacement of the characteristic reflection peaks, microscopic force is converted into macroscopic structural color change, convenience and rapidness are achieved, and the applicability is high.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of an anisotropic structural color thin film used for myocardial mechanical sensing. Background technique [0002] Cell mechanics play a miraculously important role in living organisms, regulating biological functions at the cellular and tissue levels. Abnormal mechanical performance of cells often affects dysfunctional functions in vivo, therefore, cell mechanics has gradually been considered as an element of disease evaluation. In order to effectively measure cell mechanics, researchers have developed some mechanical detection techniques, such as atomic force microscopy, traction force microscopy, and elastic micropillar array detection. [0003] Although the above-mentioned methods have great advantages in biomechanical determination and observation of subcellular structures, most of these techniques rely on complex equipment, tedious work, a...

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Problems solved by technology

[0003] Although the above methods have great advantages in biomechanical determination and observation of subcellular structures, most of these techniques rely on complex equipment, tedious work, and simulation calculations, which are often expensive and time-consuming

In addition, some techniques may even cause mechanical damage to the cells during the measurement process, leading to a loss of confidence in the results

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