A kind of photocrosslinkable hydrogel and preparation method thereof

A cross-linked hydrogel, photosensitive technology, applied in the field of hydrogel, can solve the problem of low mechanical strength of keratin hydrogel, which restricts the deep application of keratin hydrogel, and takes 10 or several hours Time and other issues, to achieve the effect of short gelation time, mild conditions and good biocompatibility
CN107043467BActive Publication Date: 2020-06-19DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2020-06-19

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Abstract

The invention relates to photo-crosslinkable hydrogel and a preparation method thereof. A matrix of the hydrogel comprises keratin; the keratin contains a plurality of free sulfhydryl groups. The preparation method comprises the following steps: dissolving the keratin into a buffering solution, and adding a photoinitiator; after sufficiently dissolving, illuminating under an ultraviolet lamp to form the photo-crosslinkable hydrogel. According to the hydrogel provided by the invention, the gelling time of materials is short, and the mechanical strength is high; the photo-crosslinkable hydrogel can be used for in-vivo injection and gelling, and has wide application value in the aspects of biomedicines, tissue engineering, medicine delivery and the like.
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Description

technical field

[0001] The invention belongs to the field of hydrogels, in particular to a photocrosslinkable hydrogel and a preparation method thereof. Background technique

[0002] Hydrogel is a hydrophilic cross-linked three-dimensional polymer network material that can swell in water and retain a large amount of water without dissolving. Hydrogel has superior water absorption performance, and has good responsiveness to the external environment, storage stability, strength and softness, and exhibits good biocompatibility. It has great potential in biomedicine, tissue engineering and drug delivery. High application value.

[0003] The crosslinking methods of hydrogel usually include chemical crosslinking, physical crosslinking, high energy radiation crosslinking, photocrosslinking and so on. The photocrosslinking method can be quickly formed within a few minutes under normal temperature and pressure, and the reaction conditions are mild, and the process is easy to contro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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