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A kind of photocrosslinkable hydrogel and preparation method thereof

A cross-linked hydrogel, photosensitive technology, applied in the field of hydrogel, can solve the problem of low mechanical strength of keratin hydrogel, which restricts the deep application of keratin hydrogel, and takes 10 or several hours Time and other issues, to achieve the effect of short gelation time, mild conditions and good biocompatibility

Active Publication Date: 2020-06-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some of these methods have a long gelation time, which takes more than 10 hours or several days; the mechanical strength of keratin hydrogel obtained by some methods is low; some methods need to use toxic chemical cross-linking agents, such as glutaraldehyde, etc. , to form a three-dimensional cross-linked network structure
These problems have restricted the deep application of keratin hydrogels to a certain extent.

Method used

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  • A kind of photocrosslinkable hydrogel and preparation method thereof
  • A kind of photocrosslinkable hydrogel and preparation method thereof
  • A kind of photocrosslinkable hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Add 0.0005 g of cysteine ​​powder to 2 mL of PBS buffer, then add 0.02 g of Irgacure 2959, fully dissolve at 50° C., and then add 0.1 g of keratin powder. Stir to dissolve and then irradiate under ultraviolet light. The method resulted in the formation of keratin gels, i.e., photocrosslinkable hydrogels, within 4 days. For a physical picture of the gel, see figure 1 .

Embodiment 2

[0036] Add 0.003 g of dithiothreitol powder to 2 mL of PBS buffer, then add 0.01 g of Irgacure 2959, fully dissolve at 50° C., and then add 0.1 g of keratin powder. Stir to dissolve and then irradiate under ultraviolet light. The method can form a keratin gel within 50 minutes, that is, a photocrosslinkable hydrogel. For a physical picture of the gel, see figure 2 .

Embodiment 3

[0038] Add 0.003 g of glutathione powder to 2 mL of PBS buffer, then add 0.02 g of Irgacure 2959, fully dissolve at 50° C., and then add 0.2 g of keratin powder. Stir to dissolve and then irradiate under ultraviolet light. The method can form a keratin gel within 20 minutes, that is, a photocrosslinkable hydrogel. For a physical picture of the gel, see image 3 .

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Abstract

The invention relates to photo-crosslinkable hydrogel and a preparation method thereof. A matrix of the hydrogel comprises keratin; the keratin contains a plurality of free sulfhydryl groups. The preparation method comprises the following steps: dissolving the keratin into a buffering solution, and adding a photoinitiator; after sufficiently dissolving, illuminating under an ultraviolet lamp to form the photo-crosslinkable hydrogel. According to the hydrogel provided by the invention, the gelling time of materials is short, and the mechanical strength is high; the photo-crosslinkable hydrogel can be used for in-vivo injection and gelling, and has wide application value in the aspects of biomedicines, tissue engineering, medicine delivery and the like.

Description

technical field [0001] The invention belongs to the field of hydrogels, in particular to a photocrosslinkable hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a hydrophilic cross-linked three-dimensional polymer network material that can swell in water and retain a large amount of water without dissolving. Hydrogel has superior water absorption performance, and has good responsiveness to the external environment, storage stability, strength and softness, and exhibits good biocompatibility. It has great potential in biomedicine, tissue engineering and drug delivery. High application value. [0003] The crosslinking methods of hydrogel usually include chemical crosslinking, physical crosslinking, high energy radiation crosslinking, photocrosslinking and so on. The photocrosslinking method can be quickly formed within a few minutes under normal temperature and pressure, and the reaction conditions are mild, and the process is easy to contro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/28C08J3/24C08L89/00
CPCC08J3/075C08J3/24C08J3/28C08J2389/00
Inventor 杨光姚依茜曹禺李炎李颖
Owner DONGHUA UNIV
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