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Photocuring 3D printing preparation method of degradable meniscus scaffold

A 3D printing and meniscus technology, applied in medical science, prosthesis, additive processing, etc., can solve the problems of low printing accuracy, large difference in mechanical strength, and inability to achieve precise control of the meniscus structure, and achieve high printing accuracy. , good biocompatibility, no cytotoxic effect

Active Publication Date: 2021-01-15
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its mechanical strength is quite different from that of the natural meniscus, and the printing accuracy is not high, so it is impossible to achieve precise regulation of the meniscus structure

Method used

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  • Photocuring 3D printing preparation method of degradable meniscus scaffold
  • Photocuring 3D printing preparation method of degradable meniscus scaffold
  • Photocuring 3D printing preparation method of degradable meniscus scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] In a 250 mL round bottom flask equipped with mechanical stirring, nitrogen inlet tube, thermometer and dropping funnel, add 16.8 g of hexamethylene diisocyanate (HDI), and then add 20.0 g of polyethylene glycol diol (molecular weight 1000) and 90.0 g of polycaprolactone diol (molecular weight: 3000) were added dropwise into a three-necked flask, while maintaining the temperature of the reaction system in the flask at 50 °C. After the dropwise addition, the mixture continued to react for 2 h. The catalyst stannous octoate (600ppm of reactant mass) was added to the system to promote the reaction to fully occur. The degree of reaction was monitored by Fourier transform infrared, and when the characteristic infrared absorption peak of the isocyanate group no longer decreased, a mixture of 0.1 g of hydroquinone and 11.6 g of hydroxyethyl acrylate was added dropwise to the system, maintaining the temperature of the system at 80°C c. After the dropwise addition is completed,...

Embodiment 2

[0047] In a 250 mL round bottom flask equipped with mechanical stirring, nitrogen inlet tube, thermometer and dropping funnel, add 16.8 g of hexamethylene diisocyanate (HDI), and then add 40.0 g of polyethylene glycol diol (molecular weight 1000) and 90.0 g of polycaprolactone diol (molecular weight: 3000) were added dropwise into a three-necked flask, while maintaining the temperature of the reaction system in the flask at 80 °C. After the dropwise addition, the mixture continued to react for 14h. The catalyst stannous octoate (600ppm of reactant mass) was added to the system to promote the reaction to fully occur. The degree of reaction was monitored by Fourier transform infrared, and when the characteristic infrared absorption peak of the isocyanate group no longer decreased, a mixture of 0.1 g of hydroquinone and 7.0 g of hydroxyethyl acrylate was added dropwise to the system, maintaining the temperature of the system at 80°C c. After the dropwise addition is completed, ...

Embodiment 3

[0049] In a 250 mL round bottom flask equipped with mechanical stirring, nitrogen inlet tube, thermometer and dropping funnel, add 22.2 g of isophorone diisocyanate (IPDI), and then add 20.0 g of polyethylene glycol diol (molecular weight 1000) and 80.0 g of polycaprolactone diol (molecular weight: 4000) were added dropwise into a three-necked flask, while maintaining the temperature of the reaction system in the flask at 100 °C. After the dropwise addition, the mixture continued to react for 4 h. The catalyst stannous octoate (600 ppm of reactant mass) was added to the system to promote the reaction to take place fully. The degree of reaction was monitored by Fourier transform infrared, and when the characteristic infrared absorption peak of the isocyanate group no longer decreased, a mixture of 0.1 g of hydroquinone and 13.9 g of hydroxyethyl acrylate was added dropwise to the system, maintaining the temperature of the system at 50°C c. After the dropwise addition is compl...

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Abstract

The invention relates to a photocuring 3D printing preparation method of a degradable meniscus scaffold, and belongs to preparation of biomedical tissue engineering scaffold materials. The photosensitive resin for printing the meniscus scaffold is prepared from the following raw material components in parts by weight of 10-80 parts of urethane acrylate, 20-80 parts of acrylate monomer, 0.5-3.0 parts of free radical type photoinitiator and 0.001-0.5 part of defoaming agent. The method comprises the following steps of adding photosensitive resin into a resin tank of a 3D printer, carrying out equipment printing according to set printing parameters to obtain a meniscus scaffold blank, cleaning with ethanol, carrying out ultraviolet curing, and carrying out oven curing to obtain a meniscus scaffold sample piece. The meniscus scaffold provided by the invention is good in biocompatibility and has mechanical properties similar to those of a natural meniscus, and photocuring printing has the characteristics of high precision, high speed and capability of accurately controlling a three-dimensional structure and a porous structure of the scaffold.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to the preparation of a scaffold material for biomedical tissue engineering, in particular to a photocuring 3D printing preparation method for a degradable tissue engineering meniscus scaffold. Background technique [0002] The meniscus is a kind of white cartilage tissue between the cartilage on the articular surface. Its smooth surface can significantly reduce the friction between the articular surfaces during exercise. In recent years, with the popularity of sports and the aging population, the incidence of meniscus injury has increased year by year, and more and more patients are troubled by this disease. However, due to the lack of blood supply, innervation and lymphatic return of the meniscus, the self-healing ability after the injury is very poor; if it is not treated in time, it will develop into osteoarthritis, which will seriously affect the daily li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/56A61L27/58C08F283/00C08F220/20C08F220/28C08F222/14B33Y70/00
CPCA61L27/18A61L27/50A61L27/56A61L27/58A61L2430/06B33Y70/00C08F283/008C08L51/08C08F220/20C08F222/103C08F220/1811C08F222/104
Inventor 敖英芳丁国成孙牧旸胡晓青于然黄伟李昕盼
Owner PEKING UNIV THIRD HOSPITAL
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