36 results about "Small artery" patented technology

A device captures and assists in the removal of a thrombus in arteries, even in small arteries. The device uses a soft coil mesh to engage the surface of a thrombus, and a guidewire is used to retract the soft coil mesh with the captured thrombus. The soft coil is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical element forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls.

The present invention relates to the unexpected finding that vessels smaller than even the smallest arteries (i.e. arterioles) thicken, become dysfunctional and cause end organ damage to tissues as diverse as the brain and the kidney. This invention provides a method to improve the structure and function of arterioles and preserve the function of end organs such as the brain and kidney.

The invention discloses a hair growth inducer, which comprises an active ingredient composed of tofacitinib and minoxidil with a mass percentage of 0.1:99.9-99.9:0.1. The hair growth inducing agent provided by the invention, its active ingredient comprises tofacitinib and minoxidil, wherein tofacitinib is a kind of JAK inhibitor, can interact with target cells (such as dermis, epidermis, dermal papilla cells or hair follicles) Cell) specific protein active site selectively binds, inhibits the transmission of cell pathway signals and the synthesis of characteristic cytokines, thereby reducing the symptoms associated with hair loss diseases; Minoxidil is a potassium ion channel opener that can directly relax Vascular smooth muscle has a powerful dilation effect on small arteries, reduces peripheral resistance, promotes the growth of hair follicle cells, and thus regenerates hair; the combination of these two substances synergistically acts on the target protein of target cells and vascular smooth muscle, and inhibits cytokines Synthesis and accelerated blood circulation, in order to achieve a significant effect of promoting hair regeneration.

The present invention discloses oral medicine liquid for treating primary hypertension and its preparation process. The oral medicine liquid has active components prepared with roasted astragalus root, Dangshen, fried white atractylodes rhizome, dried old orange peel, angelica and other 18 kinds of Chinese medicinal materials, and is prepared through twice decoctions, concentrating decoction, bottling and sterilizing. It can eliminate repeated spasm of body's small arteries, eliminate stasis matter and restore renal blood flow to stabilize blood pressure. It has convenient taking, no recurrence, no toxic side effect and other advantages. The present invention also discloses the new application of the medicine liquid in preparing medicine.

The invention relates to novel pharmacological action of traditional Chinese medicine salvianolic acid A and application thereof in the preparation of products for preventing, relieving and/or treating pulmonary arterial hypertension and its complications. The salvianolic acid A has the advantages that the salvianolic acid A has the pharmacological action of relieving pulmonary circulation pressure rise, the pharmacological actions of relieving right heart failure due to pulmonary arterial hypertension, improving right ventricular hypertrophy and right ventricular enlargement, improving heart injury due to pulmonary arterial hypertension, and restoring from heart failure, and the pharmacological actions of lowering endothelin-1 level in pulmonary tissues, relieving pulmonary arterial remodeling and improving pathologic damage of pulmonary tissues; the salvianolic acid A is a monomer compound extracted from Salvia miltiorrhiza, has low toxicity, has a wide source range of material, has promising application and development prospect, is an ideal novel traditional Chinese medicine monomer for treating pulmonary arterial hypertension and its complications, and may be applied to prepare products for preventing, relieving and treating pulmonary arterial hypertension and its complications, such as chronic obstructive pulmonary emphysema, chronic pulmonary heart disease and heart failure.

The invention relates to a rapid hemostatic. Preparation raw materials of the rapid hemostatic comprise microporous starch, calcium ions or zinc ions, chitosan or chitin. In every 100 g of the microporous starch, the addition amount of the chitosan or chitin is 1 to 50 g, the addition amount of the calcium ions is 10 to 500 micromoles, or the addition amount of the zinc ions is 6 to 80 micromoles. When the rapid hemostatic disclosed by the invention is not used, the temperature of skin at a wound cannot be increased obviously, and sharp temperature rise of the wound during hemostasis can be effectively prevented, so that pains of a patient due to the fact that the temperature of the wound is increased when an existing hemostatic is used are avoided, and the novel hemostatic can be used for hemostasis of internal and external wounds under various middle and small arteries.

The invention relates to the technical field of medical equipment, and discloses blood vessel expansion equipment. The blood vessel expansion equipment comprises an expansion stent, a monitor, a dataprocessor and an electromagnetic suspension driving assembly; the expansion stent has the shrinkage form and the expansion form and is used for excising thromboses and expanding the blood vessels; themonitor is used for detecting the position and the form of the expansion stent, and generating data signals according to the detected position and form; the data processor is in signal connection with the monitor and is used for generating control signals according to the data signals; the electromagnetic suspension driving assembly is in signal connection with the data processor and is used fordriving the expansion stent to move according to the control signals and driving the expansion stent to be switched into the expansion form from the shrinkage form according to the control signals. The diameter of the expansion stent in the blood vessel expansion equipment in the shrinkage form can be made smaller, the blood vessel expansion equipment can be applied to thrombosis treatment of medium and small arteries and veins, and the influence of the initial guiding-in position of the expansion stent on a patient is smaller.

A kind of compound medicines for treating the diseases associated with blood supply of heart is a composition of adenosine and nitrate chosen from glycerin nitrate, isosorbitol nitrate and 5-isosorbitol mononitrate.

The invention relates to a medical teaching aid, in particular to the manufacture of simulated subcutaneous tissue used for simulating skin of high-simulation human body model and TPE and other thermoplastic elastic bodies for simulating muscles, a skeleton is formed by using hard PVC and a 10% X-ray contrast agent mould and is provided with a simulated bone marrow cavity, and a metaphyseal end isprovided with simulated cancellous bone; the skeleton can be developed on an X-ray film without metal artifacts; the limbs on one side are made into various fractures with fracture lines/sections andare provided with a full-automatic blood circulation simulator for simulating the connection of arterioles; a simulated joint dislocation is made on the other side of the limbs without fracture; thefirst aid of limbs fracture can be fixed by a small splint, external fixation such as small splint and the like can be adopted after the fracture is manually restored, and complicated fracture can betreated by internal fixation of operation, so that the injured artery has lifelike small artery jet bleeding during the operation; the model can be used for carrying out various orthopedic operationssuch as bone traction, reduction of joint dislocation and the like, the model is used for carrying out orthopedic emergency treatment and various orthopedic operation skills training on medical students in the department of bone injuries in medical colleges and hospitals, and the teaching effect is obviously improved.

The invention discloses application of 18 beta-glycyrrhetinic acid in preparing a drug for treating pulmonary arterial hypertension. An experiment result of the invention shows that when the 18 beta-glycyrrhetinic acid is used in a safe dose range, the 18 beta-glycyrrhetinic acid with the dose of 200mg/kg can remarkably improve the mean pulmonary arterial pressure and the right ventricular systolic pressure of a mouse and lowers the right ventricular and pulmonary small artery remodeling; and the experiment result proves that the 18 beta-glycyrrhetinic acid has the therapeutical effect to thepulmonary arterial hypertension.

The invention relates to the technical field of traditional Chinese medicine, in particular to a hypotensive composition. The composition comprises the following ingredients in parts by mass: 20 to 25 parts of sticktight, 8 to 15 parts of celery roots, 8 to 20 parts of peanut herbs, 10 to 24 parts of polygonum multiflorum, 10 to 25 parts of liquorice, 4 to 8 parts of achyranthes bidentata, 2 to 6 parts of corn stigma, 2 to 6 parts of mulberry leaves and 2 to 4 parts of bulbus fritillariae cirrhosae. The hypotensive composition has the beneficial effects that 1, the hypotensive composition has the effects of calming the liver wind and relieving the peripheral artery spasm, so that excessive qi and blood reduction is realized, the hypotensive goal is achieved, when the hypotensive composition is used for treating hypertension, the goals of good curative effect and no side effect are achieved, and the used raw medicine is cheap and can be easily obtained; 2, the hypotensive composition has the functions of clearing the heat, calming the liver, dissipating phlegm and activating blood circulation, and is mainly used for hypertension and hyperlipidemia, the production process is simple, the raw materials can be easily obtained, the hypotensive composition can be made into various medicine preparations, and the hypotensive composition belongs to pure traditional medicine composite medicine with the advantages that the curative effect is exact, safety and convenience are realized, the side effect is small, and the price is low.

The invention provides application of myosin 1b as a target for atherosclerosis diagnosis and treatment. Whether a subject suffers from atherosclerosis or not is judged by detecting the expression level of the myosin 1b in blood of the subject, and if a mRNA expression level of the myosin 1b in a blood sample is up-regulated (highly expressed), the owner of the blood sample is an atherosclerotic patient. Detection results are accurate and reliable, and the application value of clinical diagnosis is achieved; besides, atherosclerotic plaque can be reduced by targeting a myosin 1b gene or protein, a foundation is laid for developing novel drugs for treating the atherosclerotic based on the target, and potential application value is achieved.

The invention provides a heart rate variability detection method based on a smart phone camera. According to the method, a finger is attached to a camera of the smart phone, a flash lamp of the smart phone is turned on, the camera is used for shooting a video for a period of time, then a video signal is processed, and a pulse wave signal can be extracted from the video signal. The principle of the method is very similar to that of photoelectric volume pulse waves. When the heart is contracted, the small artery of the fingertip is hyperemia, the light absorption is strong, and the image is dark; when the heart is diastolic, blood of the small artery of the fingertip flows back, light absorption is weak, and the image is bright. Therefore, the brightness change of the image reflects the blood volume change when the heart beats, and a time sequence pulse wave signal can be obtained by calculating a brightness value for each frame of image. And time domain peak detection or spectrum analysis can be carried out on the wave signal to calculate a heart rate value. The feature points of the pulse waves are further analyzed, the time interval of each heartbeat is calculated, and then heart rate variability analysis can be conducted.

The invention discloses a micro needle-shaped electrode for identifying arteries and veins in an operation. The micro needle-shaped electrode comprises the following steps: measuring blood sample saturation values of main arteries, middle arteries and small arteries of normal adult monkeys; measuring blood sample saturation values of main veins, middle veins and small veins, respectively measuring two main arteries, two middle arteries and two small arteries; simultaneously measuring two main veins, two middle veins, two small veins, surgically anatomizing spermatocordia veins; measuring each vein and artery, measuring the blood oxygen saturation degree of each artery and vein, and statistically analyzing arterial and venous differences, and counting the difference between the artery average value and the vein average value, and judging whether the measured value has comparability and overlapping. According to the micro needle-shaped electrode designed according to the arteriovenous blood oxygen saturation degree principle, arteries and veins can be effectively distinguished in an operation by noninvasively detecting the blood oxygen saturation degree in a blood vessel, the micro needle-shaped electrode is used for distinguishing arteries and veins in a varicocele operation, operation accidental injuries can be effectively reduced, and the postoperative effect can be effectively improved.

The invention relates to a Carboxy-DiI compound as well as a preparation method and application thereof; the Carboxy-DiI compound is used as a fluorescent dye with higher water solubility, is high influorescence efficiency, can be used for arterial perfusion of a living heart and uniform labeling of micro-artery vascular endothelial cells, and is good in specificity and high in sensitivity.

The invention discloses gloves with a chilblain preventing function. Each glove comprises an outer layer, a Chinese herbal medicament-filled layer, an inner surface layer and a massage layer; the Chinese herbal medicament-filled layer is arranged between the outer layer and the inner surface layer; the massage layer is embedded into the inner surface layer; the Chinese herbal medicament-filled layer consists of Chinese herbal ointment, a volatilization preventing layer and an inward-permeable layer; the volatilization preventing layer is adhered to the outer surface of the Chinese herbal ointment for preventing chilblain; and the inward-permeable layer is adhered to the inner surface of the Chinese herbal ointment for preventing the chilblain. The gloves with the chilblain preventing function are provided with the Chinese herbal ointment for preventing the chilblain and the massage layers, have the functions of activating local subcutaneous small artery blood flow stasis and accelerating blood circulation, and can effectively prevent the chilblain from generating and effectively keep hands away from the chilblain.

The new application of the proton pump inhibitor and the derivative thereof in treating pulmonary arterial hypertension is found for the first time. According to the present invention, a monocrotaline is adopted to induce a rat pulmonary arterial hypertension model, a platelet derivative growth factor-BB (Platelet-Derived Growth Factor, PDGF-BB) is adopted to induce abnormal proliferation of pulmonary arterial smooth muscle cells (PASMC), and it is found that the proton pump inhibitors such as dexlansoprazole and the like and the derivatives thereof can reduce the pulmonary arterial pressure, alleviate the thickening of small arteries in the lung, inhibit the abnormal proliferation of the PASMC, so pulmonary arterial hypertension is treated.

The invention relates to a noninvasive continuous blood pressure measurement device and a method. By the combination of the technology of ultrasound echo accurate measurement artery volume and the technology of artery volume compensation and precise measurement of ultrasound echo time delay, precise calculation of positions at arterial walls of large arteries can be performed, and accurate artery diameters or cross sectional area numerical values are calculated. Physical quantity with measuring significance of blood volume in a direct characterization artery is obtained. An infrared light intensity signal in an existing blood volume compensation method is replaced by the physical quantity, and negative effects on a measurement result by environmental light and blood volume of peripheral small arteries and veins can be completely removed. In addition, the noninvasive continuous blood pressure measurement device and the method can be directly used on large arteries of superficial layers and matched with an external pressurization air sac and a servo control pressure tracing device, so that the method can be an artery blood vessel volume compensation method in real significance. Continuous blood pressure wavy noninvasive measurement on main arteries can be achieved, and accuracy of the continuous blood pressure wavy measurement is greatly improved.

An electrode for continuously stimulating a facial nerve root capable of a stable holding required for an electrode that continuously stimulates a facial nerve root, and an apparatus for monitoring electromyograms of facial muscles using the electrode for continuously stimulating the facial nerve root, are provided. The electrode for continuously stimulating the facial nerve root comprises an electrode unit, a contact unit, a guard unit, an extension unit, and a wire unit. The electrode for continuously stimulating the facial nerve root is held by clamping the extension unit between the facial nerve root and the anterior inferior cerebellar artery or the small artery so that the contact unit closely contacts to the facial nerve root and is fixed.