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Application of butyric acid and salts thereof in preparation of medicine for treating or preventing gastric ulcer

A gastric ulcer and drug technology, applied in the field of medicine, can solve problems such as limited clinical efficacy, and achieve the effects of promoting gastric mucus secretion, preventing or treating gastric ulcer, and reducing gastric mucosal shedding

Inactive Publication Date: 2016-01-13
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, conventional drugs are mostly used for the clinical treatment of gastric ulcer, such as proton pump inhibitors, histamine H2 receptor antagonists, etc., and their clinical efficacy is limited. Therefore, it is necessary to provide a new drug for the treatment of gastric ulcer

Method used

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  • Application of butyric acid and salts thereof in preparation of medicine for treating or preventing gastric ulcer
  • Application of butyric acid and salts thereof in preparation of medicine for treating or preventing gastric ulcer
  • Application of butyric acid and salts thereof in preparation of medicine for treating or preventing gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Randomly group 32 BALB / c mice into 8 experimental groups that are evenly distributed, and perform modeling as follows:

[0046] Normal group: refers to the normal control group without any treatment;

[0047] Ethanol group: refers to the control group that was modeled with ethanol but without any drug intervention;

[0048] The first sodium butyrate group: refers to the dosage of 50 mg sodium butyrate / kg mice, after feeding the mice with sodium butyrate, and then using ethanol to create a model;

[0049] The second sodium butyrate group: refers to the dosage of 100 mg sodium butyrate / kg mice, after the mice are fed with sodium butyrate, and then ethanol is used to create a model;

[0050] Tertiary sodium butyrate group: refers to the dosage of 200mg sodium butyrate / kg mice, after feeding the mice with sodium butyrate, and then using ethanol to create a model;

[0051]The fourth sodium butyrate group: refers to the dosage of 400mg sodium butyrate / kg mice, after feed...

Embodiment 2

[0059] In this embodiment, the pathological sections of the gastric tissue of each experimental group mentioned in Example 1 were performed HE staining and PAS staining to detect the symptoms of gastric ulcer damage in the gastric tissue of the mice, wherein those skilled in the art can It should be understood that the above-mentioned HE staining and PAS staining of gastric tissue of mice are commonly used techniques in the art, which are not specifically limited in this embodiment of the present invention. diagram 2-1 Shown are the results of HE staining (hematoxylin-eosinstaining, hematoxylin-eosin staining) on ​​the stomach tissues of mice in each group, Figure 2-2 The results of PAS staining (Periodic Acid-Schiff staining) of the stomach tissues of the mice of each group are shown. Such as diagram 2-1 and Figure 2-2 As shown, for the ethanol group, the four layers of the gastric wall of the mice were roughly clear, but obvious pathological changes appeared. Destroye...

Embodiment 3

[0061] 3.1) The present embodiment measures malondialdehyde and protein carbonyl content in each experimental group mouse stomach protein mentioned in Example 1, wherein, the malondialdehyde content is measured using the thiobarbituric acid (TBA) method, according to Malondialdehyde is condensed with TBA, and the red product formed has the maximum absorption at 532nm, and the content of malondialdehyde per mg of protein (μmol / gprot) is calculated.

[0062] The specific operation process is as follows: take 0.1 ml of 10% gastric mucosal tissue homogenate, and perform the following operations according to the instructions of the malondialdehyde test box:

[0063] ①Preparation of TBA storage solution: Weigh an appropriate amount of TBA, and prepare a TBA storage solution with a mass concentration of 0.37% with TBA preparation solution.

[0064] ② Preparation of MDA detection working solution: prepare MDA detection working solution according to the ratio of TBA diluent: TBA storag...

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Abstract

The invention discloses an application of butyric acid and salts thereof in the preparation of medicines for treating or preventing gastric ulcer, and belongs to the field of medicine. According to the above application, the butyric acid and salts thereof, through anti-inflammation and antioxidation, promote the secretion of gastric mucus, upregulate the apoptin BCL2, downregulate the pro-apoptotic protein Bax, have positive curative and preventive effects on gastric ulcer injury, effectively reduce falling, defect, atrophy and bleeding of the gastric mucous membrane, and have important significance to the prevention or treatment of gastric ulcer.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of butyric acid and its salt in the preparation of medicines for treating or preventing gastric ulcer. Background technique [0002] Gastric ulcer is an ulcer disease that occurs between the cardia and the pylorus, and is a common clinical gastric mucosal lesion. If gastric ulcer cannot be treated in time, perforation, bleeding, obstruction and gastric ulcer canceration are prone to occur, which will bring great pain to patients physically and mentally. Studies have shown that active oxygen can not only directly damage the cell structure, but also promote the production of inflammatory cytokines, such as IL-1β, TNF-α and IL-6, which are the main factors that cause gastric ulcer. At present, conventional drugs are mostly used for the clinical treatment of gastric ulcer, such as proton pump inhibitors, histamine H2 receptor antagonists, etc., and their clinical efficacy is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P1/04
Inventor 王方岩刘佳明褚茂平姜勇王金丹付瑶阳陈筱筱
Owner WENZHOU MEDICAL UNIV
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